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Thrombus composition and thrombolysis resistance in stroke
Res Pract Thromb Haemost. 2023 May 16;7(4):100178. doi: 10.1016/j.rpth.2023.100178. eCollection 2023 May.ABSTRACTA State of the Art lecture titled "Thrombus Composition and Thrombolysis Resistance in Stroke" was presented at the ISTH Congress in 2022. Intravenous thrombolysis (IVT) remains the only pharmacologic option to re-establish cerebral perfusion at the acute phase of ischemic stroke. IVT is based on the administration of recombinant tissue plasminogen activator with the objective of dissolving fibrin, the major fibrillar protein component of thrombi. Almost 30 years on from its introduction, although the clinical b...
Source: Thrombosis and Haemostasis - August 4, 2023 Category: Hematology Authors: Benoit Ho-Tin-No é Jean-Philippe Desilles Mikael Mazighi Source Type: research

Erythrocyte aggregation in sudden flow arrest is linked to hyperthermia, hypoxemia and band 3 availability
CONCLUSIONS: We show that the C-terminal domain of band 3 plays a pivotal role in RBC aggregation. Further, aggregation is enhanced by hyperthermia and hypoxemia.PMID:35841276 | DOI:10.1111/jth.15821
Source: Thrombosis and Haemostasis - July 16, 2022 Category: Hematology Authors: Samantha Weber-Fishkin Harrison S Seidner Geoffrey Gunter Mary D Frame Source Type: research

Association of antithrombotic medications and composition of thrombi retrieved by mechanical thrombectomy in acute ischemic stroke
Timely restoration of blood perfusion through thrombolysis and/or mechanical thrombectomy (MT) is an important step in salvaging ischemic brain in stroke patients. MT has opened an avenue for histological evaluation of thrombi and over the last couple of years our knowledge on the thromboembolus histological and mechanical properties and effects of these properties on the success of MT has grown significantly [1,2]. Two major classes of antithrombotic therapies, including antiplatelet and anticoagulant drugs, have been used for both management and prevention of stroke.
Source: Thrombosis Research - September 26, 2021 Category: Hematology Authors: Mehdi Abbasi, Oana Madalina Mereuta, Sean F. Fitzgerald, Daying Dai, Alejandro A. Rabinstein, Ramanathan Kadirvel, David F. Kallmes, Waleed Brinjikji Tags: Letter to the Editors-in-Chief Source Type: research

Carotid artery vulnerable plaque model for cerebrovascular events by conventional ultrasound & amp; contrast-enhanced ultrasound: A preliminary study
CONCLUSION: The vulnerable plaque model established by conventional ultrasound combined with contrast-enhanced ultrasound has good diagnostic value for the characteristic plaque of carotid artery with cerebrovascular events.PMID:34511491 | DOI:10.3233/CH-211216
Source: Clinical Hemorheology and Microcirculation - September 13, 2021 Category: Hematology Authors: Qin Wang Yunqian Huang Yuke Zhang Yuqun Wang Yanchun Xie Lixia Zhang Ying Lu Man Chen Source Type: research

Utility of intestinal intravital microscopy for the study of CNS injury-induced immunodepression syndrome (CIDS)
CONCLUSIONS: Our results suggest that PTS with subsequent LPS challenge poses as a viable model to further study CIDS using intravital microscopy of the intestinal microcirculation.PMID:34487026 | DOI:10.3233/CH-219109
Source: Clinical Hemorheology and Microcirculation - September 6, 2021 Category: Hematology Authors: Bashir Bietar Juan Zhou Christian Lehmann Source Type: research

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