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Prevalence of atrial fibrillation and reasons for undertreatment with oral anticoagulants
ConclusionsIn the population of V ästernorrland County, a very high AF prevalence of 4.7% was found, of which just over 90% would theoretically benefit from OAC treatment. This is higher than previously reported and stresses the importance of stroke prevention in this large patient group.
Source: Journal of Thrombosis and Thrombolysis - September 13, 2023 Category: Hematology Source Type: research

Outcomes of therapeutic plasma exchange in severe autoimmune hemolytic anemia hospitalizations: An analysis of the National Inpatient Sample
CONCLUSION: Hospitalizations with severe AIHA that received TPE had higher rates of adverse in-hospital outcomes.PMID:37395043 | DOI:10.1111/trf.17445
Source: Transfusion - July 3, 2023 Category: Hematology Authors: Ali Abdelhay Amir A Mahmoud Omar Ammari Rami Dalbah Mouna Reghis Anas Hashem Mouaz Alkasem Mariam Mostafa Source Type: research

Hypercoagulability evaluation in congenital red blood cell disorders using thrombin generation assay
Congenital red blood cell (RBC) disorders are common diseases in the general population. The main outcomes are increased deformability due to erythrocyte instability, increased susceptibility to oxidative stress, and intravascular hemolysis. Hemolytic anemia is associated with thrombosis risk [1]. Main mechanisms are related to hypercoagulability, endothelial damage, altered blood flow, and decreased nitric oxide. Hypercoagulability is well documented in sickle cell disease (SCD) [2]. However, other RBC disorders are associated with pulmonary embolism, hypertension, non-ischemic stroke, and adverse vascular manifestations ...
Source: Thrombosis Research - March 23, 2023 Category: Hematology Authors: Guillaume Feugray, Maximilien Grall, C écile Dumesnil, Ygal Benhamou, Valery Brunel, Véronique Le Cam Duchez, Agnès Lahary, Paul Billoir Tags: Letter to the Editors-in-Chief Source Type: research

Macrocytosis in Mitochondrial DNA Deletion Syndromes
Acta Haematol. 2023 Feb 10. doi: 10.1159/000529311. Online ahead of print.ABSTRACTLarge single mtDNA (mitochondrial DNA) deletion syndrome is a rare inborn error of metabolism with variable heteroplasmy levels and clinical phenotype among affected individuals. Chronic progressive external ophthalmoplegia (CPEO) is the most common phenotype in adults with this form of mitochondrial disease [1-2]. The common CPEO clinical manifestations are ptosis and ophthalmoplegia. More variable phenotypic manifestations of CPEO (CPEO plus) include involvement of the peripheral nervous system and myopathy. Here, we describe a 62-year-old ...
Source: Acta Haematologica - February 12, 2023 Category: Hematology Authors: Farida Almarzooqi Hilary Vallance Michelle M Mezei Anna Lehman Gabriella Horvath Bojana Rakic Leslie Zypchen Andre Mattman Source Type: research

Clinical impact of oral anticoagulation among octogenarians with atrial fibrillation and anaemia
AbstractOur study aimed to describe the efficacy and safety of oral anticoagulation (OAC) use in elderly patients (>  or = 80 years-old) with atrial fibrillation (AF) and concomitant anaemia. Data for this study were sourced from AF Research Database (NCT03760874). AF patients aged ≥ 80 who received OAC treatment, both direct oral anticoagulant (DOAC) and vitamin K antagonist (VKA) were selected. Partici pants were categorized as anaemic and non-anaemic. The primary outcome was the occurrence of overall bleeding. The primary effectiveness outcome was the occurrence of thromboembolic events (a composite of isch...
Source: Journal of Thrombosis and Thrombolysis - December 6, 2022 Category: Hematology Source Type: research

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