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From Cerebellar Apoplexy in 1849 to Cerebellar Stroke in the 2020s: Robert Dunn's Contribution
Cerebellum. 2021 Mar 1. doi: 10.1007/s12311-021-01240-z. Online ahead of print.ABSTRACTStroke of the cerebellum represents about 10% of strokes of the brain. Both infarction and hemorrhage manifest with symptoms related to the location and extent of the lesion(s). Bilateral cerebellar infarcts constitute up to one third of all cerebellar infarctions. The leading cause of cerebellar infarcts is emboli of cardiac origin or from intra-arterial sources. Potential complications include brainstem compression and hydrocephalus. Malignant cerebellar edema is a life-threatening complication of ischemic posterior circulation stroke ...
Source: Cerebellum - March 1, 2021 Category: Neuroscience Authors: Mario Manto Lazaros C Triarhou Source Type: research

A modified murine photothrombotic stroke model: a minimally invasive and reproducible cortical and sub-cortical infarct volume and long-term deficits
In conclusion, this modified model helps to understand stroke pathogenesis and minimize the animals' numbers which help to increase the scientific and statistical potential in pre-clinical studies.PMID:37656197 | DOI:10.1007/s00221-023-06696-5
Source: Experimental Brain Research - September 1, 2023 Category: Neuroscience Authors: Mohd Salman Saifudeen Ismael Tauheed Ishrat Source Type: research

High incidence of adverse cerebral blood flow responses to spreading depolarization in the aged ischemic rat brain
Spreading depolarizations (SDs) occur spontaneously in the brain after stroke, exacerbate ischemic injury, and thus emerge as a potential target of intervention. Aging predicts worse outcome from stroke; yet, the impact of age on SD evolution is not clear.Cerebral ischemia was induced by bilateral common carotid artery occlusion (2VO) in young (8-9 week-old, n=8) and old (2 year-old, n=6) anesthetized rats. Sham-operated animals of both age groups served as control (n=12). Electrocorticogram, direct current potential, and cerebral blood flow (CBF) variations were acquired via a small craniotomy above the parietal cortex.
Source: Neurobiology of Aging - August 17, 2015 Category: Neuroscience Authors: Ákos Menyhárt, Péter Makra, Borbála É. Szepes, Orsolya M. Tóth, Péter Hertelendy, Ferenc Bari, Eszter Farkas Source Type: research

Postoperative 30-day outcomes after craniotomy for supratentorial AVM resection in children
ConclusionIn the NSQIP-P dataset, the incidence of perioperative complications and suboptimal outcomes among patients undergoing AVM resection were low.
Source: Journal of Clinical Neuroscience - September 4, 2019 Category: Neuroscience Source Type: research

Transorbital neuroendoscopic surgery for the treatment of skull base lesions
In this study, we aimed to retrospectively review the largest experience to our knowledge with regards to surgical outcomes of skull base pathologies treated with a TONES procedure. Forty patients (aged 3–89years) underwent 45 TONES procedures between the years of 2006–2013. Pathologies were cerebrospinal fluid leak repair (n=16), traumatic fracture (n=8), tumor (n=11), meningoencephalocele (n=5), hematoma (n=1), and infection (n=4). Three patients had a persistent complication at 3months, including a case each of enophthalmos (unnoticed by patient), epiphora (delayed presentation at 2months requiring dacryocystorhinos...
Source: Journal of Clinical Neuroscience - November 10, 2015 Category: Neuroscience Source Type: research

Long-term utility and complication profile of open craniotomy for biopsy in patients with idiopathic encephalitis
Publication date: Available online 12 December 2016 Source:Journal of Clinical Neuroscience Author(s): Kalil G. Abdullah, Yin Li, Prateek Agarwal, Nikhil R. Nayak, Jayesh P. Thawani, Ramani Balu, Timothy H. Lucas Neurosurgeons are often asked to perform open biopsy for diagnosis of encephalitis after medical investigations are non-diagnostic. These patients may be critically ill with multiple comorbidities. Patients and their families often request data regarding the success rates and complication profile of biopsy, but minimal literature exists in this area. Retrospective chart review of all patients undergoing open brai...
Source: Journal of Clinical Neuroscience - December 11, 2016 Category: Neuroscience Source Type: research