• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

The therapeutic potential of induced pluripotent stem cells after stroke: evidence from rodent models.
Abstract Stroke is the second most common cause of death and the leading cause of disability in the world. About 30% of the people that are affected by stroke die within a year; 25% of the patients that survive stroke remain in need of care after a year. Therefore, stroke is a major burden for health care costs. The most common subtype is ischemic stroke. This type is characterized by a reduced and insufficient blood supply to a certain part of the brain. Despite the high prevalence of stroke, the currently used therapeutic interventions are limited. No therapies that aim to restore damaged neuronal tissue or to p...
Source: Current Stem Cell Research and Therapy - July 28, 2015 Category: Stem Cells Authors: Zents K, Copray S Tags: Curr Stem Cell Res Ther Source Type: research

iPS Cell Transplantation Increases Regeneration and Functional Recovery after Ischemic Stroke in Neonatal Rats
Abstract Limited treatments are available for perinatal/neonatal stroke. Induced pluripotent stem cells (iPSCs) hold therapeutic promise for stroke treatment, but the benefits of iPSC transplantation in neonates are relatively unknown. We hypothesized that transplanted iPS cell‐derived neural progenitors (iPSC‐NPCs) would increase regeneration after stroke. Mouse pluripotent iPSCs were differentiated into neural progenitors using a retinoic acid protocol. Differentiated neural cells were characterized by using multiple criteria and assessments. Ischemic stroke was induced in postnatal day 7 (P7) rats by occluding the r...
Source: Stem Cells - August 5, 2014 Category: Stem Cells Authors: Monica Chau, Todd C. Deveau, Mingke Song, Xiaohuan Gu, Dongdong Chen, Ling Wei Tags: Original Research Source Type: research

iPSC Transplantation Increases Regeneration and Functional Recovery After Ischemic Stroke in Neonatal Rats
Abstract Limited treatments are available for perinatal/neonatal stroke. Induced pluripotent stem cells (iPSCs) hold therapeutic promise for stroke treatment, but the benefits of iPSC transplantation in neonates are relatively unknown. We hypothesized that transplanted iPSC‐derived neural progenitor cells (iPSC‐NPCs) would increase regeneration after stroke. Mouse pluripotent iPSCs were differentiated into neural progenitors using a retinoic acid protocol. Differentiated neural cells were characterized by using multiple criteria and assessments. Ischemic stroke was induced in postnatal day 7 (P7) rats by occluding the ...
Source: Stem Cells - November 26, 2014 Category: Stem Cells Authors: Monica J. Chau, Todd C. Deveau, Mingke Song, Xiaohuan Gu, Dongdong Chen, Ling Wei Tags: Embryonic Stem Cells/Induced Pluripotent Stem Cells Source Type: research

Intravenously Transplanted Human Bone Marrow Endothelial Progenitor Cells Engraft Within Brain Capillaries, Preserve Mitochondrial Morphology, and Display Pinocytotic Activity Towards BBB Repair in Ischemic Stroke Rats
This article is protected by copyright. All rights reserved.
Source: Stem Cells - January 30, 2017 Category: Stem Cells Authors: Svitlana Garbuzova ‐Davis, Edward Haller, Roger Lin, Cesario V. Borlongan Tags: Regenerative Medicine Source Type: research

Mesenchymal stem cells in the treatment of ischemic stroke: progress and possibilities.
Authors: Doeppner TR, Hermann DM Abstract Stroke is a major cause of death and long-term disability in industrialized countries, and the only causal therapy for stroke comprises recombinant tissue plasminogen activator(rt-PA)-mediated recanalization of the occluded vessel. New experimental strategies focus on neuroregenerative approaches, among which the application of mesenchymal stem cells (MSCs) has gained increasing attention. MSCs, like other stem cells, have the capacity of unlimited self-renewal giving rise to differentiated cells from various cell lineages. Bone marrow (BM)-derived MSCs are the most frequen...
Source: Stem Cells and Cloning: Advances and Applications - December 1, 2015 Category: Stem Cells Tags: Stem Cells Cloning Source Type: research

Extracellular Vesicles Improve Post-Stroke Neuroregeneration and Prevent Postischemic Immunosuppression
Although the initial concepts of stem cell therapy aimed at replacing lost tissue, more recent evidence has suggested that stem and progenitor cells alike promote postischemic neurological recovery by secreted factors that restore the injured brain’s capacity to reshape. Specifically, extracellular vesicles (EVs) derived from stem cells such as exosomes have recently been suggested to mediate restorative stem cell effects. In order to define whether EVs indeed improve postischemic neurological impairment and brain remodeling, we systematically compared the effects of mesenchymal stem cell (MSC)-derived EVs (MSC-EVs) ...
Source: Stem Cells Translational Medicine - September 17, 2015 Category: Stem Cells Authors: Doeppner, T. R., Herz, J., Gorgens, A., Schlechter, J., Ludwig, A.-K., Radtke, S., de Miroschedji, K., Horn, P. A., Giebel, B., Hermann, D. M. Tags: Enabling Technologies for Cell-Based Clinical Translation, Mesenchymal Stem Cells Source Type: research

Mitochondrial transplantation and immune response of human bone marrow mesenchymal stem cells for the Therapeutic of ischemic stroke
Curr Stem Cell Res Ther. 2023 May 5. doi: 10.2174/1574888X18666230505103407. Online ahead of print.ABSTRACTIschemic stroke is the leading cause of death and disability worldwide, with increasing incidence and mortality, imposing a significant social and economic burden on patients and their families. However, cerebral vascular occlusion leads to acute loss of neurons and destruction of synaptic structures. The limited treatment options cannot adequately address intra-neuronal mitochondrial dysfunction due to stroke. Therefore, stem cell-derived mitochondria transplantation plays an important role in neuronal protection and...
Source: Current Stem Cell Research and Therapy - May 8, 2023 Category: Stem Cells Authors: Yidong Liao Jiang Ming Wenxue Song Guangtang Chen Junshuan Cui Longcai He Zili Wang Xudong Wang Mingsong Xiong Hua Yang Kaya Xu Source Type: research

Transplantation of unique subpopulation of fibroblasts, Muse cells, ameliorates experimental stroke possibly via robust neuronal differentiation
This article is protected by copyright. All rights reserved.
Source: Stem Cells - September 21, 2015 Category: Stem Cells Authors: Hiroki Uchida, Takahiro Morita, Kuniyasu Niizuma, Yoshihiro Kushida, Yasumasa Kuroda, Shohei Wakao, Hiroyuki Sakata, Yoshiya Matsuzaka, Hajime Mushiake, Teiji Tominaga, Cesario V. Borlongan, Mari Dezawa Tags: Regenerative Medicine Source Type: research

Meta-Analysis: The Clinical Application of Autologous Adult Stem Cells in the Treatment of Stroke
CONCLUSION: Most of the trials were early phase studies that focused on safety rather than efficacy. Stem cells have demonstrated breakthrough results in the field of regenerative medicine. Therefore, study design could be improved in the future by enrolling a larger patient population and focusing more on localized delivery rather than intravenous transplantation. Trials should also introduce a more standardized method of analyzing and reporting clinical outcomes to achieve a better comparable outcome and possibly recognize the full potential that these cells have to offer.PMID:35002259 | PMC:PMC8721025 | DOI:10.2147/SCCAA.S344943
Source: Stem Cells and Cloning: Advances and Applications - January 10, 2022 Category: Stem Cells Authors: Noora Hassani Sebastien Taurin Sfoug Alshammary Source Type: research

Pages: 1  2  3  4  5  6  7