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Procedure: SPECT

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Total 384 results found since Jan 2013.

Clinical implications for Translocator Protein (TSPO) imaging using 123ICLINDE SPECT: A feasible approach
Conclusions The preliminary results imply that [123I]CLINDE-SPECT is a feasible approach for TSPO imaging in neurological disorders associated with microglial activation and/or increased TSPO expression. The development of methods that do not need arterial blood sampling for quantification of TSPO will be important to ease implementation in a daily clinical setting. Further clinical studies are needed to determine the precise role of TSPO imaging in predicting clinical outcome and treatment response.
Source: Journal of Nuclear Medicine - May 23, 2016 Category: Nuclear Medicine Authors: Thomsen, G., Jensen, P., Feng, L., Knudsen, L., Knudsen, G., Pinborg, L. Tags: Neurosciences/Neurology. Miscellaneous Source Type: research

Serum neurofilament light chain in functionally relevant coronary artery disease and adverse cardiovascular outcomes
CONCLUSION: While sNfL concentrations did not show a diagnostic role for fCAD, in contrast, sNfL was a strong and independent predictor of cardiovascular outcomes, including all-cause death, cardiovascular death and stroke/TIA.PMID:36714921 | DOI:10.1080/1354750X.2023.2172211
Source: Biomarkers - January 30, 2023 Category: Research Authors: Melissa Amrein None Stephanie Meier Ibrahim Sch äfer Sabine Schaedelin Eline Willemse Pascal Benkert Joan Walter Christian Puelacher Tobias Zimmermann Daniela Median Caroline Egli David Leppert Raphael Twerenbold Michael Zellweger Jens Kuhle Christian Mu Source Type: research

Neurobiological insight into hyperbaric hyperoxia
ConclusionsThe present study firstly confirmed the rCBF distribution increase during HBO in sensory‐motor and visual cortices and it showed for the first time a higher perfusion tracer distribution in areas encompassed in dorsal attention system and in default mode network. These findings unfold both the externally directed cognition performance improvement related to the HBO and the internally directed cognition states during resting state conditions, suggesting possible beneficial effects in TBI and stroke patients.This article is protected by copyright. All rights reserved.
Source: Acta Physiologica - May 21, 2013 Category: Physiology Authors: Alessandro Micarelli, Hans Jacobsson, Stig A Larsson, Cathrine Jonsson, Marco Pagani Tags: Regular Paper Source Type: research

Depressive symptoms, atherosclerotic burden and cerebral blood flow disturbances in a cohort of octogenarian men from a general population
Conclusion: In this population-based cohort of octogenarian men free from stroke or dementia, a proportion of subjects with depressive symptoms was low. Still, men with borderline or mild depression scores had lower social and physical activity, persistent smoking habit, worse peripheral circulation in legs, and cerebral perfusion changes in basal nuclei, thalamus and subcortical white matter. Regional CBF decline could be partly mediated by higher SBP.
Source: BMC Psychiatry - Latest articles - December 26, 2013 Category: Psychiatry Authors: Arkadiusz Siennicki-LantzLena André-PeterssonPer WollmerSölve Elmståhl Source Type: research

In Vivo Molecular Imaging of Thrombosis and Thrombolysis Using a Fibrin-Binding Positron Emission Tomographic Probe Molecular Imaging
Conclusions— We demonstrated that FBP7 is suitable for molecular imaging of thrombosis and thrombolysis in vivo and represents a promising candidate for bench-to-bedside translation.
Source: Circulation: Cardiovascular Imaging - July 15, 2014 Category: Radiology Authors: Ay, I., Blasi, F., Rietz, T. A., Rotile, N. J., Kura, S., Brownell, A. L., Day, H., Oliveira, B. L., Looby, R. J., Caravan, P. Tags: PET and SPECT Molecular Imaging Source Type: research

Intra-arterial delivery of human bone marrow mesenchymal stem cells is a safe and effective way to treat cerebral ischemia in rats.
In this study, the therapeutic effects of bone marrow stem cells (BMSCs) delivered by intra-arterial (IA) and intravenous (IV) injection in a rat transient middle cerebral artery occlusion model (MCAO) are compared. Histological analysis demonstrated that the IA route bypasses the pulmonary system and directs the cells to the ischemic parts of the brain more efficiently. The BMSCs delivered via the IA route promoted angiogenesis and improved functional recovery. The cerebral blood flow (CBF) of the rats was monitored during the IA injection process. No reduction in CBF or microstrokes was detected. Brain perfusion and meta...
Source: Cell Transplantation - November 4, 2014 Category: Cytology Authors: Du S, Guan J, Mao G, Liu Y, Ma S, Bao X, Gao J, Feng M, Li G, Ma W, Yang Y, Zhao RC, Wang R Tags: Cell Transplant Source Type: research

Carotid velocities determine cerebral blood flow deficits in elderly men with carotid stenosis
Authors: Siennicki-Lantz A, Wollmer P, Elmståhl S Abstract To examine if mild carotid stenosis correlates with silent vascular brain changes, we studied a prospective population-based cohort "Men born in 1914." Data from followups at ages 68 and 81, have been used. Carotid ultrasound was performed at age 81, and cerebral blood flow (CBF) was measured with SPECT at age 82. Out of 123 stroke-free patients, carotid stenosis <50% was observed in 94% in the right and 89% in the left internal carotid arteries (ICAs). In these subjects, Peak Systolic Velocities in ICA correlated negatively with CBF in a majority of se...
Source: International Journal of Vascular Medicine - December 1, 2014 Category: Cardiology Tags: Int J Vasc Med Source Type: research

Apraxic agraphia following bithalamic damage.
Conclusion: Neurolinguistic follow-up findings and SPECT evidence in this unique patient with bithalamic damage for the first time indicate that AA in the alphabetic script may result from diaschisis affecting the frontal writing centre. The findings suggest that the thalamus is critically implicated in the neural network subserving graphomotor processing. PMID: 25682350 [PubMed - as supplied by publisher]
Source: Brain and Cognition - February 12, 2015 Category: Neurology Authors: Vandenborre D, van Dun K, Mariën P Tags: Brain Cogn Source Type: research