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Total 77 results found since Jan 2013.

Fool Me Once: An Uncommon Presentation of PE
​BY FREDDIE IRIZARRY-DELGADO; VAROON KAKAIYA; & AHMED RAZIUDDIN, MDAn 86-year-old African-American woman was brought to the ED by her daughter after two days of nutritional neglect, abdominal pain, and altered mental status. Her daughter said her mother felt lightheaded, appeared dehydrated, and vomited nonbilious watery fluid once. The patient had a history of diabetes mellitus type 2, DVT/PE, dementia, and early signs of parkinsonism.Her vital signs were remarkable only for tachypnea (24 bpm). Her troponin I was markedly elevated at 1.7 ng/mL. A D-dimer was ordered because of her history of unprovoked DVT/PE, and i...
Source: The Case Files - November 27, 2018 Category: Emergency Medicine Tags: Blog Posts Source Type: research

Looking Past Dementia Reveals Hidden Life Threats
Conclusion Acute delirium is commonly underdiagnosed, and can be masked by chronic alterations in cognition and mentation. Delirium has many causes, and can be assessed using the acronym DELIRIUM. The most common presentations suggesting delirium over dementia are short-term memory loss, rapid fluctuation in condition, acute alteration, and a condition present that may be responsible for delirium. Management includes searching for causes of acute alteration in mental status, negating environmental factors of delirium, and—only when necessary—reducing the patient’s threat to themselves or providers by using butyrophen...
Source: JEMS Special Topics - August 13, 2018 Category: Emergency Medicine Authors: Joseph K. Mesches, NRP, FP-C Tags: Exclusive Articles Patient Care Source Type: news

Mosaic RAS/MAPK variants cause sporadic vascular malformations which respond to targeted therapy
CONCLUSION. Our findings uncover a major cause of sporadic VMs of different clinical types and thereby offer the potential of personalized medical treatment by repurposing existing licensed cancer therapies. FUNDING. This work was funded or supported by grants from the AVM Butterfly Charity, the Wellcome Trust (UK), the Medical Research Council (UK), the UK National Institute for Health Research, the L’Oreal-Melanoma Research Alliance, the European Research Council, and the National Human Genome Research Institute (US).
Source: Journal of Clinical Investigation - March 12, 2018 Category: Biomedical Science Authors: Lara Al-Olabi, Satyamaanasa Polubothu, Katherine Dowsett, Katrina A. Andrews, Paulina Stadnik, Agnel P. Joseph, Rachel Knox, Alan Pittman, Graeme Clark, William Baird, Neil Bulstrode, Mary Glover, Kristiana Gordon, Darren Hargrave, Susan M. Huson, Thomas Source Type: research

Getting Social in the Real World
Although it would be facetious to say that social media has reached a tipping point into ubiquity, it is only relatively recently that it has been used by pharma to collect and analyze patient data. This use of social media may only be in its infancy but as a quick and inexpensive way to gather large-scale, real-world data it is growing rapidly.Technology always outstrips the glacial pace that industry moves at, but this ‘sudden’ move creates a sharp learning curve for many pharma companies. Issues around regulation and resources will hinder some, while others will fail to see the value of ‘social health’.Popular s...
Source: EyeForPharma - March 6, 2017 Category: Pharmaceuticals Authors: Danielle Barron Source Type: news

The evolving role of oral hormonal therapies and review of conjugated estrogens/bazedoxifene for the management of menopausal symptoms.
Authors: Parish SJ, Gillespie JA Abstract This review describes the evolving role of oral hormone therapy (HT) for treating menopausal symptoms and preventing osteoporosis, focusing on conjugated estrogens/bazedoxifene (CE/BZA). Estrogens alleviate hot flushes and prevent bone loss associated with menopause. In nonhysterectomized women, a progestin should be added to estrogens to reduce the risk of endometrial cancer. Use of HT declined since the Women's Health Initiative (WHI) studies showed that HT does not prevent coronary heart disease (CHD) and that conjugated estrogens/medroxyprogesterone acetate increased th...
Source: Postgraduate Medicine - February 1, 2017 Category: Internal Medicine Tags: Postgrad Med Source Type: research

Prevalence of Hypertension among Patients Attending Mobile Medical Clinics in the Philippines after Typhoon Haiyan
Conclusions Better planning and preparation by humanitarian actors seeking to decrease the overall morbidity and mortality associated with disasters should include treatment of NCDs. There is limited evidence regarding the optimal management of hypertension in disaster settings. Clinical care of patients with hypertension and other NCDs is an important part of disaster relief and recovery. We recommend future studies to determine best practices and evidence-based management of other NCDs (such as diabetes mellitus, cardiovascular disease, chronic lung disease, mental health etc.) in post-disaster settings. Competing Inter...
Source: PLOS Currents Disasters - December 20, 2016 Category: Global & Universal Authors: lindamob01 Source Type: research

Pain: a content review of undergraduate pre-registration nurse education in the United Kingdom
Pain is a global health issue with poor assessment and management of pain associated with serious disability and detrimental socio economic consequences. Pain is also a closely associated symptom of the three major causes of death in the developed world; Coronary Heart Disease, Stroke and Cancer. There is a significant body of work which indicates that current nursing practice has failed to address pain as a priority, resulting in poor practice and unnecessary patient suffering.Additionally nurse education appears to lack focus or emphasis on the importance of pain assessment and its management.
Source: Nurse Education Today - September 5, 2016 Category: Nursing Authors: Carolyn Mackintosh-Franklin Tags: Review Source Type: research

A Radiologist ’s Primer on Bundles and Care Episodes
Publication date: September 2016 Source:Journal of the American College of Radiology, Volume 13, Issue 9 Author(s): David Seidenwurm, Frank James Lexa Bundled or episode payments are among the most heavily emphasized approaches to aligning incentives and promoting care coordination, efficiency, and accountability in health care redesign. Bundled or episode payments price a market basket of services for an entire episode of care with both a clearly defined trigger and termination. Because the radiologist is “ancillary” in many bundles, the specialty is often unaware of the phenomenon. This is likely to change rapidly. ...
Source: Journal of the American College of Radiology - August 31, 2016 Category: Radiology Source Type: research

Pain in the Geriatric Patient with Advanced Chronic Disease
This article examines the data on the prevalence of pain, co-occurring symptoms, and challenges in managing pain in these conditions.
Source: Clinics in Geriatric Medicine - August 8, 2016 Category: Geriatrics Authors: Veerawat Phongtankuel, Prin X. Amorapanth, Eugenia L. Siegler Source Type: research

Patterns and consequences of multimorbidity in the general population: There is no chronic disease management without rheumatic disease management
Conclusion: Our study emphasizes RMDs as a major presence in multimorbidity in the general population. All multimorbidity patterns were associated with a wide set of adverse health outcomes. Management strategies for the patient with chronic cardiometabolic, respiratory or depressive conditions should also target RMDs. This article is protected by copyright. All rights reserved.
Source: Arthritis Care and Research - August 1, 2016 Category: Rheumatology Authors: Daniela Sim ões, Fábio A. Araújo, Milton Severo, Teresa Monjardino, Ivo Cruz, Loreto Carmona, Raquel Lucas Tags: Original Article Source Type: research

Modulatory effect of cilostazol on tramadol-induced behavioral and neurochemical alterations in rats challenged across the forced swim despair test
Publication date: Available online 30 May 2016 Source:Beni-Suef University Journal of Basic and Applied Sciences Author(s): Noha M. Gamil, Yousreya A. Maklad, Maha A.E. Ahmed, Shahira Nofal, Amany A.E. Ahmed Pain-associated depression is encountered clinically in some cases such as cancer, chronic neuropathy, and after operations. Tramadol is an opioid analgesic drug that may modulate monoaminergic neurotransmission by inhibition of noradrenaline and serotonin reuptake that may contribute to its antidepressant-like effects. Clinically, tramadol is used either alone or in combination with other NSAIDs in the treatmen...
Source: Beni Suef University Journal of Basic and Applied Sciences - May 30, 2016 Category: Science Source Type: research

A Radiologist’s Primer on Bundles and Care Episodes
Publication date: Available online 18 May 2016 Source:Journal of the American College of Radiology Author(s): David Seidenwurm, Frank James Lexa Bundled or episode payments are among the most heavily emphasized approaches to aligning incentives and promoting care coordination, efficiency, and accountability in health care redesign. Bundled or episode payments price a market basket of services for an entire episode of care with both a clearly defined trigger and termination. Because the radiologist is “ancillary” in many bundles, the specialty is often unaware of the phenomenon. This is likely to change rapidly. Rad...
Source: Journal of the American College of Radiology - May 17, 2016 Category: Radiology Source Type: research

White Doctors In Training Believe Some Disturbing Stuff About Black Patients
When it comes to emergency care, you may have a tough time if you're in pain and not a white man.  Previous research has shown that black and Hispanic patients who reported severe pain in the the ER were 22 percent less likely to receive pain medication than white patients who presented with the same complaints. And women suffer similar disparities: A 2008 study found that women wait an average of 16 minutes longer to receive pain relief for acute abdominal pain in the ER than men do. Now a new study is shedding some light on this phenomenon. "We’ve been looking at racial bias and pain perception to tr...
Source: Healthy Living - The Huffington Post - April 8, 2016 Category: Consumer Health News Source Type: news

Optimizing Acute Pain Management in the Obese Patient: Treatment and Monitoring Considerations
THE CHALLENGES OF PROVIDING SAFE AND EFFECTIVE pain management for patients with obesity are present throughout the perioperative setting. Obesity is associated with chronic medical comorbidities, such as coronary artery disease, stroke, chronic kidney disease, nonalcoholic fatty liver disease, and type 2 diabetes.1 Other obesity-associated comorbidities include breast, endometrial, ovarian, colorectal, esophageal, kidney, pancreatic, and prostate cancers, chronic back pain, and osteoarthritis.1 The demand for bariatric surgery has risen markedly in recent years with the total number of surgeries performed in the United St...
Source: Journal of PeriAnesthesia Nursing - February 27, 2016 Category: Nursing Authors: Maureen F. Cooney Tags: Pain Care Source Type: research