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Condition: Bleeding

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Gastrointestinal Bleeding in Acute Ischemic Stroke: A Population-Based Analysis of Hospitalizations in the United States
Over half of all patients admitted with acute ischemic stroke (AIS) suffer gastrointestinal complications. Our goal was to determine the burden of gastrointestinal bleeding (GIB) in hospitalized patients with AIS using the largest, all-payer, inpatient database in the United States.
Source: Journal of Stroke and Cerebrovascular Diseases - April 13, 2016 Category: Neurology Authors: Kavelin Rumalla, Manoj K. Mittal Source Type: research

Letter by Iannuccelli et al Regarding Article, "Paracetamol, Ibuprofen, and Recurrent Major Cardiovascular and Major Bleeding Events in 19 120 Patients With Recent Ischemic Stroke" Letters to the Editor
Source: Stroke - August 21, 2016 Category: Neurology Authors: Iannuccelli, C., Di Franco, M., Pulcinelli, F. M. Tags: Heart Failure, Ischemic Stroke Letters to the Editor Source Type: research

Endovascular recanalization therapy in the patients with acute ischemic stroke and active malignancy
【Background】Patients with cancer who have acute ischemic stroke are often precluded from intravenous tPA due to high risk of bleeding. In this case, endovascular recanalization therapy may be an alternative treatment option.
Source: Journal of Stroke and Cerebrovascular Diseases - March 18, 2017 Category: Neurology Authors: Man-Seok Park, Bang-Hoon Cho, Kang-Ho Choi, Joon-Tae Kim, Seung-Han Lee, Woong Yoon, Ki-Hyun Cho Source Type: research

Investigation of optimum conditions of iodine extraction image in after recanalization therapy of acute ischemic stroke
【Background and Purpose】After acute recanalization of ischemic stroke, we distinguish contrast agent leakand bleeding by dual energy CT (DECT). Discrimination confirmed the contrast agent leakage in Iodine map (IM), and confirmed bleeding in the Virtual non-contrast. However, the analysis in the default setting of IM would extract the lateral ventricle (LV). The purpose of this study is to make IM more clearly with different method which is using ΔCT values.
Source: Journal of Stroke and Cerebrovascular Diseases - March 18, 2017 Category: Neurology Authors: Kotaro Fukuda, Masataka Hayashi, Shizuka Nishikawa, Rika Fukui, Isao Tanaka Source Type: research

Intravenous Thrombolysis for Acute Ischemic Stroke in Patients with Thrombocytopenia (P4.264)
Conclusions:IV rtPA for AIS might be safe in patients with platelet count <100,000/mm3 and it is reasonable not to delay IV rtPA administration while waiting for the platelet count result, unless there is strong suspicion for abnormal platelet count .Disclosure: Dr. Mowla has nothing to disclose. Dr. Kamal has nothing to disclose. Dr. Lail has nothing to disclose. Dr. Vaughn has nothing to disclose. Dr. Mehla has nothing to disclose. Dr. Deline has nothing to disclose. Dr. Ching has nothing to disclose. Dr. Crumlish has nothing to disclose. Dr. Sawyer has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Mowla, A., Kamal, H., Lail, N., Vaughn, C., Mehla, S., Deline, C., Ching, M., Crumlish, A., Sawyer, R. Tags: Thrombolysis and Acute Evaluation in Ischemic Stroke Source Type: research

Associations of Antithrombotic Timing and Regimen with Ischemic Stroke and Bleeding Complications in Blunt Cerebrovascular Injury
Blunt carotid injuries and vertebral arterial injuries, collectively referred to as blunt cerebrovascular injuries (BCVIs), are generally rare events but are associated with high mortality rates and long-term health effects.1 The long-term effects of BCVI include loss of both cognition and function, including the ability to perform daily cognitive and mobility activities without assistance, recurrent stroke, and need for extensive rehabilitation.2-6 Blunt cerebrovascular injuries have been reported to occur in 0.1-0.7% of all trauma patients in the United States,7-10 although higher rates ( ∼1-2%) have been reported afte...
Source: Journal of Stroke and Cerebrovascular Diseases - April 14, 2020 Category: Neurology Authors: Daniel Barrera, Erica Sercy, Alessandro Orlando, Charles W. Mains, Robert Madayag, Matthew M. Carrick, Allen Tanner, Mark Lieser, David Acuna, James Yon, David Bar-Or Source Type: research

Risk analysis of post-procedural intracranial hemorrhage based on STAY ALIVE Acute Stroke Registry
Intracranial hemorrhages (ICH) are classified as symptomatic or asymptomatic according to the presence of clinical deterioration. Here, we aimed to find predictive factors of symptomatic intracranial bleeding in a registry-based stroke research.
Source: Journal of Stroke and Cerebrovascular Diseases - May 9, 2020 Category: Neurology Authors: Peter Csecsei, Gabor Tarkanyi, Edit Bosnyak, Laszlo Szapary, Gabor Lenzser, Alex Szolics, Andras Buki, Peter Hegyi, Alan Abada, Tihamer Molnar Source Type: research

Hemorrhagic stroke and anticoagulation in COVID-19
We present a retrospective study of 33 patients positive for COVID-19 with neuroimaging-documented ICH and examine anticoagulation use in this population.
Source: Journal of Stroke and Cerebrovascular Diseases - May 22, 2020 Category: Neurology Authors: Siddhant Dogra, Rajan Jain, Meng Cao, Seda Bilaloglu, David Zagzag, Sarah Hochman, Ariane Lewis, Kara Melmed, Katherine Hochman, Leora Horwitz, Steven Galetta, Jeffrey Berger Tags: Hemorrhagic stroke in COVID-19 Source Type: research

Hemorrhagic Stroke in Setting of Severe COVID-19 Infection Requiring Extracorporeal Membrane Oxygenation (ECMO)
To highlight the increased risk of hemorrhagic stroke secondary to postulated COVID-19 mediated vasculopathy with concomitant ECMO related bleeding complications.
Source: Journal of Stroke and Cerebrovascular Diseases - June 5, 2020 Category: Neurology Authors: Muhammad J. Zahid, Anam Baig, Nestor Galvez-Jimenez, Nydia Martinez Tags: Case Report Source Type: research

Safety of early antiplatelet administration in patients with acute ischemic stroke treated with alteplase (SEAPT-24)
This study aimed to examine the safety of early antiplatelet therapy administration within the first 24 h after alteplase.
Source: Journal of Stroke and Cerebrovascular Diseases - November 5, 2022 Category: Neurology Authors: Drew A. Wells, Lyndsey K. Davis, Omar Saeed, G. Morgan Jones, Cheran Elangovan, Andrei V. Alexandrov, Balaji Krishnaiah, Katherine L. March Source Type: research

Combining Human Umbilical Cord Blood Cells With Erythropoietin Enhances Angiogenesis/Neurogenesis and Behavioral Recovery After Stroke
In conclusion, our results suggest that hUCBC infusion in combination with EPO administration demonstrates therapeutic efficacy in the treatment of stroke-induced injury by promoting neurogenesis and angiogenesis. Further research that delineates the therapeutic mechanism of systemically administered hUCBC and EPO is required. Ethics Statement All experimental procedures involving animals were performed in accordance with the Guide for the Care and Use of Laboratory Animals as adopted and promulgated by the U. S. National Institutes of Health and were approved by CHA University Institutional Animal Care & Use Com...
Source: Frontiers in Neurology - April 9, 2019 Category: Neurology Source Type: research

Platelet Count Predicts Adverse Clinical Outcomes After Ischemic Stroke or TIA: Subgroup Analysis of CNSR II
Conclusion: In ischemic stroke or TIA patients with platelet count within normal range, platelet count may be a qualified predictor for long-term recurrent stroke, mortality, and poor functional outcome. Introduction Platelets exert a critical role in the pathogenesis of atherosclerotic complications of cardio-cerebrovascular disease, contributing to thrombus formation, and embolism (1, 2). Previous literature reported that platelets of various size and density are produced by megakaryocytes of different size and stages of maturation in different clinical conditions, suggesting various platelet patterns in differen...
Source: Frontiers in Neurology - April 11, 2019 Category: Neurology Source Type: research

Frequency of Hemorrhage on Follow Up Imaging in Stroke Patients Treated With rt-PA Depending on Clinical Course
Conclusions: Frequency of hemorrhagic transformation in Routine follow-up brain imaging and consecutive changes in therapeutic management were different depending on clinical course measured by NHISS score. Introduction Brain imaging 24–36 h after systemic thrombolysis for acute ischemic stroke is recommended in American Stroke Association and European Stroke Organization guidelines (1, 2). Brain imaging is performed to detect secondary bleeding or hemorrhagic transformation in order to adapt medical stroke prevention if necessary. Guideline recommendations are based on the results of the first study on rt-PA...
Source: Frontiers in Neurology - April 15, 2019 Category: Neurology Source Type: research

Influence of Sex on Stroke Prognosis: A Demographic, Clinical, and Molecular Analysis
Conclusion Our data suggest that women who suffer from IS present with a poorer functional outcome than men at 3-months, regardless of other preclinical and clinical factors during the acute phase. These relationships seem to be mediated by atrial dysfunction and inflammation. The inflammatory response is slightly higher in women; however, there are no sex differences in their functional behavior. There is a probable relationship between the molecular marker of atrial dysfunction NT-proBNP and worse functional outcome in women, and the connection seems to be more important in cardioembolic stroke patients. In patients wi...
Source: Frontiers in Neurology - April 16, 2019 Category: Neurology Source Type: research