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Infectious Etiologies of Stroke
Semin Neurol 2019; 39: 482-494 DOI: 10.1055/s-0039-1687915Central nervous system (CNS) infections are a frequently underappreciated potential etiology of cerebrovascular disease. Highlighted in this review are a selection of infectious agents that lead to cerebrovascular complications through various mechanisms including multifocal vasculopathy, focal infiltrative vasculitis and vasospasm, and direct vessel wall invasion and thrombus formation. Diagnosis of stroke due to underlying CNS infection requires a high index of clinical suspicion and careful consideration of neuroimaging, serum, and cerebrospinal fluid studies in ...
Source: Seminars in Neurology - September 17, 2019 Category: Neurology Authors: Shulman, Julie G. Cervantes-Arslanian, Anna M. Tags: Review Article Source Type: research

Stroke and syphilis: A retrospective study of 53 patients.
CONCLUSION: A diagnosis of syphilitic stroke should be suspected in young patients as a manifestation of syphilis, and tests for neurosyphilis should be routine in neurology departments to make a prompt diagnosis, thereby preventing psychological sequelae. PMID: 29631855 [PubMed - as supplied by publisher]
Source: Revue Neurologique - April 12, 2018 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Streptococcus pneumoniae meningitis and intracranial vasculopathy: Clinical correlation with improving transcranial Doppler hemodynamics (P1.322)
Conclusions:Antibiotic treatment for S. pneumoniae meningitis correlated with improvement in clinical status and TCD hemodynamics. Serial TCDs may be a potentially useful strategy in the management of bacterial meningitis.Disclosure: Dr. Idris has nothing to disclose. Dr. Tai has nothing to disclose. Dr. Tan has nothing to disclose. Dr. Tan has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Idris, M. I., Tai, S. M. L., Tan, C. T., Tan, K. S. Tags: Autoimmunity with Infection, Syphilis, Lyme, Tuberculosis, and other Bacteria Source Type: research

Acute ischemic stroke in a young female: a novel presentation of anti-GAD autoimmunity (P3.272)
Conclusions:Restricted diffusion, seen typically in ischemia, indicates cytotoxic oedema and irreversible cell damage. In this patient, we postulate a mechanism of severe CNS inflammation with cellular toxicity and small vessel vasculitis. Anti-GAD autoimmunity should be considered in young patients presenting with stroke-like episodes, particularly when accompanied by positive phenomenon.Disclosure: Dr. Neo has nothing to disclose. Dr. Lee has nothing to disclose. Dr. Lee has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Neo, X. S., Lee, K. E., Lee, R. Tags: Cerebrovascular Disease Case Reports II Source Type: research

The Great Imitator—Still Today! A Case of Meningovascular Syphilis Affecting the Posterior Circulation
We describe clinical features and imaging studies of a 50-year-old patient with Parinaud syndrome and a syphilitic dorsal midbrain infarction. Brain magnetic resonance imaging indicated vasculitis of the posterior circulation. The diagnosis of meningovascular syphilis was established by serum and cerebrospinal fluid examinations. Although rare, because of the high impact on treatment, clinicians should always be aware of meningovascular syphilis in the differential diagnosis of stroke, particularly in young and male patients with cryptogenic stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - October 2, 2014 Category: Neurology Authors: Jochen Bäuerle, Anna Zitzmann, Karl Egger, Stephan Meckel, Cornelius Weiller, Andreas Harloff Tags: Case Report Source Type: research

Stroke in a Young Patient: A Sentinel Presentation of Neurosyphilis and HIV (P2.109)
Conclusions: Neurosyphilis should be a diagnostic consideration in young patients with ischemic stroke. Clinicians should be aware of the high incidence of concomitant syphilis and HIV in at-risk populations. Effort should be made to inquire about high-risk behaviors and initiate testing for these infections early in the diagnostic workup to avoid missing these crucial diagnoses.Disclosure: Dr. Flaherty has nothing to disclose. Dr. Cutting has received personal compensation for activities with F1000.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Flaherty, E., Cutting, S. Tags: Cerebrovascular Disease and Interventional Neurology: Childhood and Young Adult Source Type: research