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Total 355 results found since Jan 2013.

Phyllanthin Averts Oxidative Stress and Neuroinflammation in Cerebral Ischemic-Reperfusion Injury through Modulation of the NF- κB and AMPK/Nrf2 Pathways
J Environ Pathol Toxicol Oncol. 2021;40(1):85-97. doi: 10.1615/JEnvironPatholToxicolOncol.2020036307.ABSTRACTCerebral ischemia-reperfusion (CIR) is a common feature of ischemic stroke and is a major cause of disability and death among stroke patients worldwide. Phyllanthin, a lignin polyphenol, is known for its varied biological properties, although its protective effects against CIR have not been reported. We evaluated the neuroprotective property of phyllanthin against CIR as well as the involvement of the AMP-activated protein kinase/nuclear factor erythroid 2-related factor 2 (AMPK/Nrf2) and nuclear factor kappa B (NF-...
Source: Journal of Environmental Pathology, Toxicology and Oncology - February 27, 2021 Category: Environmental Health Authors: Haitao Yuan Qin Yang Bo Yang Hong Xu Omaima Nasif Sankareswaran Muruganantham Jing Chen Source Type: research

Modeling the neuro-protection of theaflavic acid from black tea and its synergy with nimodipine via mitochondria apoptotic pathway
J Zhejiang Univ Sci B. 2021 Feb 15;22(2):123-135. doi: 10.1631/jzus.B2000540.ABSTRACTIschemic stroke presents a leading cause of mortality and morbidity worldwide. Theaflavic acid (TFA) is a theaflavin isolated from black tea that exerts a potentially neuro-protective effect. However, the dynamic properties of TFA-mediated protection remain largely unknown. In the current study, we evaluated the function of TFA in the mitochondria apoptotic pathway using mathematical modeling. We found that TFA-enhanced B-cell lymphoma 2 (Bcl-2) overexpression can theoretically give rise to bistability. The bistability is highly robust aga...
Source: J Zhejiang Univ Sci ... - February 22, 2021 Category: Science Authors: Dan Mu Huaguang Qin Mengjie Jiao Shaogui Hua Tingzhe Sun Source Type: research