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Specialty: Biomedical Science
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Total 34 results found since Jan 2013.

The KATP channel opener, nicorandil, ameliorates brain damage by modulating synaptogenesis after ischemic stroke
by Yuanzheng Zhao, Zhuoying Yang, Yuanhong He, Ruonan Sun, Heping Yuan With population growth and aging, more and more patients with cerebral infarction have varying degrees of disability. ATP-sensitive potassium (KATP) channels regulate many cellular functions by coupling metabolic status with cell membrane electrical activity. Nicorandil (N-(2-hydroxyethyl)-nicotin amide nitrate) is the first KATP channel opener approved for clinical use. It has been reported that it might exert protective effects on the cerebral infarction by increasing cerebral blood flow and reducing inflammation. However, only a few studies explored...
Source: PLoS One - January 26, 2021 Category: Biomedical Science Authors: Yuanzheng Zhao Source Type: research

Robotic treatment of the upper limb in chronic stroke and cerebral neuroplasticity: a systematic review.
Authors: Bressi F, Bravi M, Campagnola B, Bruno D, Marzolla A, Santacaterina F, Miccinilli S, Sterzi S Abstract Stroke is the second cause of mortality and the third cause of long-term disability worldwide. Deficits in upper limb (UL) capacity persist at 6 months post-stroke in 30-66% of hemiplegic stroke patients with major limitations in activity of daily living (ADL), thus making the recovery of paretic UL function the main rehabilitation goal. Robotic rehabilitation plays a crucial role since it allows to perform a repetitive, intensive, and task-oriented treatment, adaptable to the patients' residual abilities...
Source: Journal of Biological Regulators and Homeostatic Agents - January 4, 2021 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Machine learning-based segmentation of ischemic penumbra by using diffusion tensor metrics in a rat model
Recent trials have shown promise in intra-arterial thrombectomy after the first 6 –24 h of stroke onset. Quick and precise identification of the salvageable tissue is essential for successful stroke management....
Source: Journal of Biomedical Science - July 15, 2020 Category: Biomedical Science Authors: Duen-Pang Kuo, Po-Chih Kuo, Yung-Chieh Chen, Yu-Chieh Jill Kao, Ching-Yen Lee, Hsiao-Wen Chung and Cheng-Yu Chen Tags: Research Source Type: research

A review of machine learning techniques in photoplethysmography for the non-invasive cuff-less measurement of blood pressure
Publication date: April 2020Source: Biomedical Signal Processing and Control, Volume 58Author(s): C. El-Hajj, P.A. KyriacouAbstractHypertension or high blood pressure is a leading cause of death throughout the world and a critical factor for increasing the risk of serious diseases, including cardiovascular diseases such as stroke and heart failure. Blood pressure is a primary vital sign that must be monitored regularly for the early detection, prevention and treatment of cardiovascular diseases. Traditional blood pressure measurement techniques are either invasive or cuff-based, which are impractical, intermittent, and unc...
Source: Biomedical Signal Processing and Control - February 13, 2020 Category: Biomedical Science Source Type: research

EMG-driven hand model based on the classification of individual finger movements
Publication date: April 2020Source: Biomedical Signal Processing and Control, Volume 58Author(s): Maria V. Arteaga, Jenny C. Castiblanco, Ivan F. Mondragon, Julian D. Colorado, Catalina Alvarado-RojasAbstractThe recovery of hand motion is one of the most challenging aspects in stroke rehabilitation. This paper presents an initial approach to robot-assisted hand-motion therapies. Our goal was twofold: firstly, we have applied machine learning methods to identify and characterize finger motion patterns from healthy individuals. To this purpose, Electromyographic (EMG) signals have been acquired from flexor and extensor muscl...
Source: Biomedical Signal Processing and Control - January 30, 2020 Category: Biomedical Science Source Type: research

Brain functions and unusual β-amyloid accumulation in the hypertensive white matter lesions of rats.
This study used Sprague Dawley (SD) rats with stroke-prone renovascular hypertension (RHRSP) to establish an animal model of hypertensive white matter lesions (WML), so as to explore the brain functions and unusual β-amyloid (Aβ) accumulation in WML. Hypertensive WML and brain dysfunctions were evaluated by measuring the caudal arterial pressure of model rats, and by observing the histomorphological deformations o f the prefrontal lobe, temporal lobe, hippocampus and corpus callosum, as well as by counting of the number of neurons using Hematoxylin and Eosin (H and E) staining, and by evaluating the changes in rat brain ...
Source: Journal of Biological Regulators and Homeostatic Agents - August 8, 2019 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Editors' Choice Stroke prevention: Learning from the master (and COMMANDER)
Adding rivaroxaban to standard therapy in patients with heart failure and no atrial fibrillation did not show any beneficial effect on death risk.
Source: Science Translational Medicine - September 19, 2018 Category: Biomedical Science Authors: Santulli, G. Tags: Editors ' Choice Source Type: research

Clinical and Basic Evaluation of the Prognostic Value of Uric Acid in Traumatic Brain Injury.
Conclusions: UA acted to attenuate neuronal loss, cerebral perfusion impairment and neurological deficits in TBI mice through suppression of neuronal and vascular oxidative stress. Following TBI, active antioxidant defense in the brain may result in consumption of UA in the serum, and thus, a decreased serum UA level could be predictive of good clinical recovery. PMID: 30013449 [PubMed - in process]
Source: International Journal of Medical Sciences - July 18, 2018 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

United states of amnesia: rescuing memory loss from diverse conditions EDITORIAL
ABSTRACT Amnesia – the loss of memory function – is often the earliest and most persistent symptom of dementia. It occurs as a consequence of a variety of diseases and injuries. These include neurodegenerative, neurological or immune disorders, drug abuse, stroke or head injuries. It has both troubled and fascinated humanity. Philosophers, scientists, physicians and anatomists have all pursued an understanding of how we learn and memorise, and why we forget. In the last few years, the development of memory engram labelling technology has greatly impacted how we can experimentally study memory and its disorders ...
Source: DMM Disease Models and Mechanisms - May 18, 2018 Category: Biomedical Science Authors: Ortega-de San Luis, C., Ryan, T. J. Tags: EDITORIAL Source Type: research

Research Articles A multidirectional gravity-assist algorithm that enhances locomotor control in patients with stroke or spinal cord injury
Gait recovery after neurological disorders requires remastering the interplay between body mechanics and gravitational forces. Despite the importance of gravity-dependent gait interactions and active participation for promoting this learning, these essential components of gait rehabilitation have received comparatively little attention. To address these issues, we developed an adaptive algorithm that personalizes multidirectional forces applied to the trunk based on patient-specific motor deficits. Implementation of this algorithm in a robotic interface reestablished gait dynamics during highly participative locomotion wit...
Source: Science Translational Medicine - July 19, 2017 Category: Biomedical Science Authors: Mignardot, J.-B., Le Goff, C. G., van den Brand, R., Capogrosso, M., Fumeaux, N., Vallery, H., Anil, S., Lanini, J., Fodor, I., Eberle, G., Ijspeert, A., Schurch, B., Curt, A., Carda, S., Bloch, J., von Zitzewitz, J., Courtine, G. Tags: Research Articles Source Type: research

Shaping innovations in long-term care for stroke survivors with multimorbidity through stakeholder engagement
ConclusionsStakeholder engagement to identify data-driven solutions is feasible but requires resources. While a number of potential interventions were identified, the final choice rested not just on stakeholder priorities but also on data availability. Further work is required to evaluate the impact and implementation of data-driven interventions for long-term stroke survivors.
Source: PLoS One - May 5, 2017 Category: Biomedical Science Authors: Euan Sadler Source Type: research

Analysis of Balance during Functional Walking in Stroke Survivors
DiscussionWe developed and demonstrated a method to assess walking balance of stroke survivors. System design and evaluation methods allow balance evaluation during functional walking in daily life. Some presented metrics show correlations with BBS scores. Clear inter- and intra-patient variations in metric values are present that cannot be explained by BBS scores, which supports the additional value of the presented system. Presented methods may be used for objective evaluation of restitution and compensation of walking balance and have a potential application in individual evidence-based therapy.
Source: PLoS One - November 16, 2016 Category: Biomedical Science Authors: Fokke B. van Meulen Source Type: research

Quality Improvement in Acute Ischemic Stroke Care in Taiwan: The Breakthrough Collaborative in Stroke
by Fang-I Hsieh, Jiann-Shing Jeng, Chang-Ming Chern, Tsong-Hai Lee, Sung-Chun Tang, Li-Kai Tsai, Hsun-Hsiang Liao, Hang Chang, Kenneth A. LaBresh, Hung-Jung Lin, Hung-Yi Chiou, Hou-Chang Chiu, Li-Ming Lien, for the BTS-Stroke Investigators In the management of acute ischemic stroke, guideline adherence is often suboptimal, particularly for intravenous thrombolysis or anticoagulation for atrial fibrillation. We sought to improve stroke care quality via a collaborative model, the Breakthrough Series (BTS)-Stroke activity, in a nationw ide, multi-center activity in Taiwan. A BTS Collaborative, a short-term learning system fo...
Source: PLoS One - August 2, 2016 Category: Biomedical Science Authors: Fang-I Hsieh Source Type: research

Upper Extremity Functional Evaluation by Fugl-Meyer Assessment Scoring Using Depth-Sensing Camera in Hemiplegic Stroke Patients
by Won-Seok Kim, Sungmin Cho, Dongyoub Baek, Hyunwoo Bang, Nam-Jong Paik Virtual home-based rehabilitation is an emerging area in stroke rehabilitation. Functional assessment tools are essential to monitor recovery and provide current function-based rehabilitation. We developed the Fugl-Meyer Assessment (FMA) tool using Kinect (Microsoft, USA) and validated it for hemiplegic stroke patients. Forty-one patients with hemiplegic stroke were enrolled. Thirteen of 33 items were selected for upper extremity motor FMA. One occupational therapist assessed the motor FMA while recording upper extremity motion with Kinect. FMA score...
Source: PLoS One - June 30, 2016 Category: Biomedical Science Authors: Won-Seok Kim Source Type: research

Vascular Risk Factors and Diseases Modulate Deficits of Reward-Based Reversal Learning in Acute Basal Ganglia Stroke
Conclusions The previously reported impairment of reward-based learning may be attributed to vascular risk factors and associated diseases, which are enriched in stroke patients. This study emphasizes the necessity of appropriate control subjects in cognition studies.
Source: PLoS One - May 9, 2016 Category: Biomedical Science Authors: Ulla K. Seidel Source Type: research