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Stroke-associated pattern of gene expression previously identified by machine-learning is diagnostically robust in an independent patient population
The objective of this study was to assess the diagnostic capacity and temporal stability of this stroke-associated transcriptional signature in an independent patient population. Publicly available whole blood microarray data generated from 23 ischemic stroke patients at 3, 5, and 24h post-symptom onset, as well from 23 cardiovascular disease controls, were obtained via the National Center for Biotechnology Information Gene Expression Omnibus. Expression levels of the ten candidate genes (ANTXR2, STK3, PDK4, CD163, MAL, GRAP, ID3, CTSZ, KIF1B, and PLXDC2) were extracted, compared between groups, and evaluated for their dis...
Source: Genomics Data - September 2, 2017 Category: Genetics & Stem Cells Source Type: research

Discovering Cerebral Ischemic Stroke Associated Genes Based on Network Representation Learning
Cerebral ischemic stroke (IS) is a complex disease caused by multiple factors including vascular risk factors, genetic factors, and environment factors, which accentuates the difficulty in discovering corresponding disease-related genes. Identifying the genes associated with IS is critical for understanding the biological mechanism of IS, which would be significantly beneficial to the diagnosis and clinical treatment of cerebral IS. However, existing methods to predict IS-related genes are mainly based on the hypothesis of guilt-by-association (GBA). These methods cannot capture the global structure information of the whol...
Source: Frontiers in Genetics - September 1, 2021 Category: Genetics & Stem Cells Source Type: research

RNA methylation pattern and immune microenvironment characteristics mediated by m6A regulator in ischemic stroke
Conclusion: The modification of m6A is closely related to the immune microenvironment. The evaluation of individual m6A modification pattern may be helpful for future immunomodulatory therapy of anti-ischemic response.
Source: Frontiers in Genetics - April 17, 2023 Category: Genetics & Stem Cells Source Type: research

Neurobiology of secure infant attachment and attachment despite adversity: A mouse model
Abstract Attachment to an abusive caregiver has wide phylogenetic representation, suggesting that animal models are useful in understanding the neural basis underlying this phenomenon and subsequent behavioral outcomes. We previously developed a rat model, in which we use classical conditioning to parallel learning processes evoked during secure attachment (odor‐stroke, with stroke mimicking tactile stimulation from the caregiver) or attachment despite adversity (odor‐shock, with shock mimicking maltreatment). Here we extend this model to mice. We conditioned infant mice (postnatal day (PN) 7‐9 or 13‐14) with prese...
Source: Genes, Brain and Behavior - August 1, 2013 Category: Genetics & Stem Cells Authors: Tania L. Roth, Charlis Raineki, Lisa Salstein, Rosemarie Perry, Tristan A. Sullivan‐Wilson, Aliza Sloan, Brianna Lalji, Elizabeth Hammock, Donald A. Wilson, Pat Levitt, Fumino Okutani, Hideto Kaba, Regina M. Sullivan Tags: Original Article Source Type: research

PhyloPen: Phylogenetic Tree Browsing Using a Pen and Touch Interface
Conclusions Our objective is to develop an interactive phylogenetic tree-browsing user interface for experts that is more dynamic and ideally more natural than commonly used browsers, ultimately allowing the user to navigate, annotate, and change the tree structure with ease. In this work-in-progress, we tested an experimental pen- and touch-based interactive browser we developed called PhyloPen. Our preliminary formative evaluations show positive results, demonstrating some usefulness of pen and touch interfaces for phylogenetic trees. However, additional work based on our formative evaluations, including the revision of ...
Source: PLOS Currents Tree of Life - November 23, 2015 Category: Genetics & Stem Cells Authors: Anthony Wehrer Source Type: research

A Novel Deep Neural Network Model for Multi-Label Chronic Disease Prediction
Conclusions concludes this work along with future work. Dataset and Data Preprocessing In the work, we mainly focus on multiple chronic disease classification. It can be formulated into a multi-label classification problem. There are three common chronic diseases are selected from the physical examination records: hypertension (H), diabetes (D), and fatty liver (FL). In the experiments, the physical examination datasets are collected from a local medical center, which contain 110,300 physical examination records from about 80,000 anonymous patients (Li et al., 2017a,b). Sixty-two feature items are selected from over 100...
Source: Frontiers in Genetics - April 23, 2019 Category: Genetics & Stem Cells Source Type: research

Identification of novel cis-regulatory regions from the Notch receptor genes lin-12 and glp-1 of Caenorhabditis elegans.
Abstract Notch signaling regulates various cellular processes such as growth, proliferation and differentiation, and plays a key role in tissue patterning during animal development. In humans, defects in Notch signaling have been implicated in cancer, stroke, neurodegeneration, as well as learning and memory deficits. The genome of the nematode Caenorhabditis elegans encodes two members of the Notch transmembrane receptor family, LIN-12 and GLP-1, which have both unique and shared developmental functions. LIN-12 affects diverse cell fate specification events at certain embryonic and larval stages, including the AB...
Source: Gene Expression Patterns : GEP - January 7, 2013 Category: Genetics & Stem Cells Authors: Regős A, Lengyel K, Takács-Vellai K, Vellai T Tags: Gene Expr Patterns Source Type: research

The Promoter Regions of Intellectual Disability-Associated Genes Are Uniquely Enriched in LTR Sequences of the MER41 Primate-Specific Endogenous Retrovirus: An Evolutionary Connection Between Immunity and Cognition
Discussion We have found that, in the human genome, the promoter regions of ID-associated genes are uniquely enriched in MER41 LTRs. More specifically, nine ID-associated genes that are putatively important in cognitive evolution exhibit MER41 LTRs in their promoter regions. As more than 100 families of HERV are integrated into our genome, it was important to determine whether our findings are specific to MER41 and to ID-associated genes, and if so to what extent. Among the 133 families of HERV explored here, MER41 is the only family whose LTRs were found with statistically high frequency in the promoter regions of ID-ass...
Source: Frontiers in Genetics - April 11, 2019 Category: Genetics & Stem Cells Source Type: research

Sex Difference of Radiation Response in Occupational and Accidental Exposure
Conclusion and Outlook This review summarizes the data from major human studies on the health risks of radiation exposure and shows that sex can potentially influence the prolonged response to radiation exposure (Figure 1 and Tables 1, 2). These data suggest that long-term radiosensitivity in females is higher than that in males who receive a comparable dose of radiation. Our analysis of the literature agrees with the conclusions of the recent report on the Biological effects of ionizing radiation (BEIR VII) published in 2006 by the National Academy of Sciences (NAS), United States (National Research Council, 2006). The B...
Source: Frontiers in Genetics - May 2, 2019 Category: Genetics & Stem Cells Source Type: research

An Improved Deep Learning Model: S-TextBLCNN for Traditional Chinese Medicine Formula Classification
Conclusion: The combination of formula feature representation and the S-TextBLCNN model improve the accuracy in formula efficacy classification. It provides a new research idea for the study of TCM formula compatibility.
Source: Frontiers in Genetics - December 22, 2021 Category: Genetics & Stem Cells Source Type: research

Ensemble-AHTPpred: A Robust Ensemble Machine Learning Model Integrated With a New Composite Feature for Identifying Antihypertensive Peptides
Hypertension or elevated blood pressure is a serious medical condition that significantly increases the risks of cardiovascular disease, heart disease, diabetes, stroke, kidney disease, and other health problems, that affect people worldwide. Thus, hypertension is one of the major global causes of premature death. Regarding the prevention and treatment of hypertension with no or few side effects, antihypertensive peptides (AHTPs) obtained from natural sources might be useful as nutraceuticals. Therefore, the search for alternative/novel AHTPs in food or natural sources has received much attention, as AHTPs may be functiona...
Source: Frontiers in Genetics - April 28, 2022 Category: Genetics & Stem Cells Source Type: research

Can transcranial photobiomodulation improve cognitive function? A systematic review of human studies
CONCLUSIONS: tPBM seems to improve cognitive function. However, only half of the reviewed clinical trials were randomized control trials, further investigation is warranted.PMID:36371017 | DOI:10.1016/j.arr.2022.101786
Source: Ageing Research Reviews - November 12, 2022 Category: Genetics & Stem Cells Authors: Tsz-Lok Lee Zihan Ding Agnes S Chan Source Type: research