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Hand-Arm Bimanual Intensive Therapy Including Lower Extremities (HABIT-ILE) in adults with chronic stroke: protocol of a randomised controlled trial
This study will compare the effect of 50 hours of HABIT-ILE against usual motor activity and regular rehabilitation. HABIT-ILE will be provided in a 2-week, adult’s day-camp setting, promoting functional tasks and structured activities. These tasks will continuously progress by increasing their difficulty. Assessed at baseline, 3 weeks after and at 3 months, the primary outcome will be the adults-assisting-hand-assessment stroke; secondary outcomes include behavioural assessments for hand strength and dexterity, a motor learning robotic medical device for quality of bimanual motor control, walking endurance, question...
Source: BMJ Open - April 13, 2023 Category: General Medicine Authors: Ebner-Karestinos, D., Gathy, E., Carton de Tournai, A., Herman, E., Araneda, R., Dricot, L., Macq, B., Vandermeeren, Y., Bleyenheuft, Y. Tags: Open access, Rehabilitation medicine Source Type: research

Human adipose-derived stem cells partially rescue the stroke syndromes by promoting spacial learning and memory in mouse middle cerebral artery occlusion model
IntroductionGrowing evidence has brought stem cell therapy to the forefront as new promising approaches towards stroke treatment. Of all candidate seeding cells, adipose-derived stem cells (ADSCs) are considered as one of the most appropriate for stroke treatment. However, previous experimental data could not reach to an agreement on the efficacy of ADSC transplantation for treating stroke in vivo as well as its mechanism which hinders their further clinical translational application. Methods: To explore their in vivo mechanism of hADSC administration on neurological injury, hADSC were labeled with EGFP expressing FG12 len...
Source: BioMed Central - May 8, 2015 Category: Journals (General) Authors: Fei ZhouShane GaoLin WangChenxi SunLu ChenPing YuanHaiyang ZhaoYi YiYing QinZhiqiang DongLimei CaoHaiyan RenLiang ZhuQiang LiBing LuAibin LiangGuotong XuHongwen ZhuZhengliang GaoJie MaJun XuXu Chen Source Type: research

Dyad Training Protocol on Learning of Bimanual Cup Stacking in Individuals with Stroke: Effects of Observation Duration.
CONCLUSION: For individuals with chronic stroke, compared with the 1-minute observation alternating with physical practice, the 6-minute duration resulted in greater persistent learning. Moreover the 6-minute duration greatly enhanced the planning of bimanual cup stacking. PMID: 26387420 [PubMed - indexed for MEDLINE]
Source: Journal of the Medical Association of Thailand = Chotmaihet thangphaet - December 20, 2015 Category: Journals (General) Tags: J Med Assoc Thai Source Type: research

Relevance of the cerebral collateral circulation in ischaemic stroke: time is brain, but collaterals set the pace.
Abstract Blood supply to the brain is secured by an extensive collateral circulation system, which can be divided into primary routes, i.e., the Circle of Willis, and secondary routes, e.g., collaterals from the external to the internal carotid artery and leptomeningeal collaterals. Collateral flow is the basis for acute stroke treatment, since neurones will only survive long enough to be rescued with reperfusion therapies if there is sufficient collateral flow. Poor collateral flow is associated with worse outcome and faster growth of larger infarcts in acute stroke treatment. Therapeutic promotion of collateral ...
Source: Swiss Medical Weekly - December 12, 2017 Category: General Medicine Authors: Jung S, Wiest R, Gralla J, McKinley R, Mattle H, Liebeskind D Tags: Swiss Med Wkly Source Type: research

The key challenges of discussing end-of-life stroke care with patients and families: a mixed-methods electronic survey of hospital and community healthcare professionals.
CONCLUSION: Key topics of unmet need for education in end-of-life care in stroke have been identified and these have influenced the content of an open access, web-based educational resource. PMID: 30191909 [PubMed - in process]
Source: Journal of the Royal College of Physicians of Edinburgh - September 8, 2018 Category: General Medicine Tags: J R Coll Physicians Edinb Source Type: research

Machine learning-based patient classification system for adults with stroke: A systematic review
DISCUSSION: There is no single algorithm that performed better or worse than all others at classifying patients with stroke, in part because different input data require different algorithms to achieve optimal outcomes.PMID:34903091 | DOI:10.1177/17423953211067435
Source: Chronic Illness - December 14, 2021 Category: General Medicine Authors: Suebsarn Ruksakulpiwat Witchuda Thongking Wendie Zhou Chitchanok Benjasirisan Lalipat Phianhasin Nicholas K Schiltz Smit Brahmbhatt Source Type: research

Blunt traumatic injury of the innominate artery resulting in a stroke – A rare presentation
We present a case of traumatic injury of the innominate artery resulting in an ischemic stroke. Case presentation A 20-year-old gentleman ejected from a two wheeler and run over by a truck presented to us with multiple bleeding facial wounds and severe crush injury of his upper torso. Bedside chest X-ray revealed a widened mediastinum and multiple rib fractures with pneumothoraces bilaterally which were drained with intercostal tubes. An hour into his stay in the ED he developed left hemiparesis. CT brain showed infarcts in right temporo-parietal and occipital regions. CT angiogram of neck vessels revealed an avulsion inj...
Source: Apollo Medicine - October 23, 2014 Category: Journals (General) Source Type: research

Myasthenia gravis as a 'stroke mimic' - it's all in the history.
Abstract An 85-year-old man presented to hospital as an emergency having difficulties with swallowing and speech. In the emergency department, he was assessed as having acute onset dysphagia and dysarthria in keeping with an acute stroke. Subsequently, it became apparent that although the symptoms were indeed of relatively acute onset, there was a clear description by the patient of fatigability and diurnal variation, prompting a working clinical diagnosis of myasthenia gravis. The patient followed a turbulent clinical course, and interpretation of investigation results proved not to be straightforward in the acut...
Source: Clinical Medicine - December 1, 2014 Category: Journals (General) Authors: Shaik S, Ul-Haq MA, Emsley HC Tags: Clin Med Source Type: research

Neurostimulation for cognitive rehabilitation in stroke (NeuroCog): study protocol for a randomized controlled trial
This study is a double-blind, sham-controlled clinical trial aiming to compare the long-term effects of stimulation in two different cognitive regions after a stroke.Methods/DesignSixty patients who suffer from chronic strokes will be randomized into one of four groups: dorsolateral prefrontal cortex, cingulo-opercular network, motor primary cortex and sham stimulation. Each group will receive transcranial direct current stimulation at an intensity of 2 mA for 20 minutes daily for 10 consecutive days. Patients will be assessed with a Dysexecutive Questionnaire, Semantic Fluency Test, categorical verbal fluency and Go-no ...
Source: Trials - September 29, 2015 Category: Journals (General) Authors: Suellen AndradeBernardino Fernández-CalvoPaulo BoggioEliane de OliveiraLilze GomesJosé Pinheiro JúniorRafaela RodriguesNatália de AlmeidaGioconda MoreiraNelson Alves Source Type: research

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