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Dl-3-n-butylphthalide alleviates cognitive impairment in amyloid precursor protein/presenilin 1 transgenic mice by regulating the striatal-enriched protein tyrosine phosphatase/ERK/cAMP-response element-binding protein signaling pathway
In conclusion, the present study provided evidence to suggest that the new drug NBP improved amyloid-induced learning and memory deficits, likely through the regulation of the STEP/ERK/CREB pathway. The results revealed that NBP, as a multi-target drug, may exert a neuroprotective effect. Therefore, NBP may serve as an effective treatment for AD.PMID:35350668 | PMC:PMC8943801 | DOI:10.3892/etm.2022.11248
Source: Experimental and Therapeutic Medicine - March 30, 2022 Category: General Medicine Authors: Yan Zhao Wen-Qiang Yang Lu Yu Jing Yang Hai-Rong Zhu Lin Zhang Source Type: research

Clinical code usage in UK general practice: a cohort study exploring 18 conditions over 14 years
Conclusions This is an under-reported research area and the findings suggest the codes’ usage diversity for most conditions remained overall stable throughout the study period. Generated mental health code lists can last for a long time unlike cardiometabolic conditions and cancer. Adopting more consistent and less diverse coding would help improve data quality in primary care. Future research is needed following the transfer to the Systematised Nomenclature of Medicine Clinical Terms (SNOMED CT) coding.
Source: BMJ Open - July 25, 2022 Category: General Medicine Authors: Zghebi, S. S., Reeves, D., Grigoroglou, C., McMillan, B., Ashcroft, D. M., Parisi, R., Kontopantelis, E. Tags: Open access, General practice / Family practice Source Type: research

AHA News: He Used to Hike Mountains. A Stroke Left Him Learning to Walk Again.
FRIDAY, Dec. 16, 2022 (American Heart Association News) -- Richard Samuelian recently got back from a hike in Yosemite National Park. A few years ago, the 52-year-old couldn ' t walk down the hallway of his home in Fresno, California, without...
Source: Drugs.com - Daily MedNews - December 16, 2022 Category: General Medicine Source Type: news

Association between seropositivity for toxocariasis and cognitive functioning in older adults: an analysis of cross-sectional data from the US National Health and Nutrition Examination Survey (NHANES), 2011-2014
Conclusions In our study, seropositive toxocariasis was independently and significantly associated with worse working memory, sustained attention, processing speed and global cognition in older adults. If this association is causal, public health measures to prevent human toxocariasis might help protect older adults’ cognitive function.
Source: BMJ Open - March 1, 2023 Category: General Medicine Authors: Song, G., Yang, C., Qu, Z., Lin, X., Liu, M., Wang, Y. Tags: Open access, Epidemiology Source Type: research

Social bias in artificial intelligence algorithms designed to improve cardiovascular risk assessment relative to the Framingham Risk Score: a protocol for a systematic review
This study will employ an equity-lens to identify sources of bias (ie, race/ethnicity, gender and social stratum) in ML algorithms designed to improve CVD risk assessment relative to the FRS. A comprehensive literature search will be completed using MEDLINE, Embase and IEEE to answer the research question: do AI algorithms that are designed for the estimation of CVD risk and that compare performance with the FRS address the sources of bias inherent in the FRS? No study date filters will be imposed on the search, but English language filters will be applied. Studies describing a specific algorithm or ML approach that provid...
Source: BMJ Open - May 31, 2023 Category: General Medicine Authors: Garcha, I., Phillips, S. P. Tags: Open access, General practice / Family practice Source Type: research

Improvement of diagnostic performance of hyperacute ischemic stroke in head CT using an image-based noise reduction technique with non-black-boxed process
To date, a variety of image-based noise reduction (INR) techniques for computed tomography (CT) have been reported. They are based on iterative processes or deep learning techniques. Some INR products using iterative processes are already commercially available and have been reported to exhibit noise reduction performance better than hybrid-type iterative reconstruction (HIR) in abdominal CT [1,2]. However, the details of the processes inside these commercial INR systems are usually proprietary and cannot be readily replicated outside.
Source: Physica Medica: European Journal of Medical Physics - August 5, 2023 Category: General Medicine Authors: Tetsuya Hirairi, Katsuhiro Ichikawa, Atsushi Urikura, Hiroki Kawashima, Takasumi Tabata, Tamaki Matsunami Source Type: research

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