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Acute Ischaemic Stroke Prediction from Physiological Time Series Patterns
Conclusion We demonstrated that using trend pattern features in prediction methods improved the accuracy of stroke outcome prediction. Therefore, trend patterns of physiological time series data have an important role in the early treatment of patients with acute ischaemic stroke.
Source: Australasian Medical Journal - AMJ - May 9, 2013 Category: Journals (General) Source Type: research

Untargeted metabolomics predicts the functional outcome of ischemic stroke.
CONCLUSION: Metabolomics is a potential method to explore the blood biomarkers of acute ischemic stroke. The patients with unfavorable outcomes had a lower PAF level compared to those with favorable outcomes. PMID: 32414667 [PubMed - as supplied by publisher]
Source: J Formos Med Assoc - May 12, 2020 Category: General Medicine Authors: Chi NF, Chang TH, Lee CY, Wu YW, Shen TA, Chan L, Chen YR, Chiou HY, Hsu CY, Hu CJ Tags: J Formos Med Assoc Source Type: research

A lesion to learn: Stroke mimics
Publication date: Available online 26 March 2016 Source:Apollo Medicine Author(s): Mahir Meman, Pushpendra Nath Renjen, Dinesh M. Chaudhari Acute ischemic stroke with neurological deficit is a very debilitating condition, especially in younger patients. IV thrombolysis is the only effective treatment available in most of the centers across India. But delay in hospitalization and bleeding complications are major limitations. In addition to that, stroke mimics are another big problem. Correct identification of stroke mimics needs clinical expertise and imaging studies. Multiple studies indicate safety of thrombolysis in...
Source: Apollo Medicine - March 25, 2016 Category: Journals (General) Source Type: research

Relevance of the cerebral collateral circulation in ischaemic stroke: time is brain, but collaterals set the pace.
Abstract Blood supply to the brain is secured by an extensive collateral circulation system, which can be divided into primary routes, i.e., the Circle of Willis, and secondary routes, e.g., collaterals from the external to the internal carotid artery and leptomeningeal collaterals. Collateral flow is the basis for acute stroke treatment, since neurones will only survive long enough to be rescued with reperfusion therapies if there is sufficient collateral flow. Poor collateral flow is associated with worse outcome and faster growth of larger infarcts in acute stroke treatment. Therapeutic promotion of collateral ...
Source: Swiss Medical Weekly - December 12, 2017 Category: General Medicine Authors: Jung S, Wiest R, Gralla J, McKinley R, Mattle H, Liebeskind D Tags: Swiss Med Wkly Source Type: research

Blunt traumatic injury of the innominate artery resulting in a stroke – A rare presentation
We present a case of traumatic injury of the innominate artery resulting in an ischemic stroke. Case presentation A 20-year-old gentleman ejected from a two wheeler and run over by a truck presented to us with multiple bleeding facial wounds and severe crush injury of his upper torso. Bedside chest X-ray revealed a widened mediastinum and multiple rib fractures with pneumothoraces bilaterally which were drained with intercostal tubes. An hour into his stay in the ED he developed left hemiparesis. CT brain showed infarcts in right temporo-parietal and occipital regions. CT angiogram of neck vessels revealed an avulsion inj...
Source: Apollo Medicine - October 23, 2014 Category: Journals (General) Source Type: research

Comment Learning from TARDIS: time for more focused trials in stroke prevention
Antithrombotic therapy immediately following stroke is important to minimise the risk of recurrence, but the optimum choice and number of drugs to use are unclear, and efficacy in preventing thrombosis needs to be weighed against bleeding risk. In The Lancet, the TARDIS investigators report findings from a randomised trial1 that tested intensive antiplatelet therapy with three agents (aspirin, clopidogrel, and dipyridamole) against therapy based on current UK guidelines2 (either clopidogrel, or aspirin plus dipyridamole) for 30 days in patients with transient ischaemic attack (TIA) or ischaemic stroke.
Source: LANCET - December 20, 2017 Category: General Medicine Authors: Pierre Amarenco Tags: Comment Source Type: research

Intra-arterial treatment in acute ischaemic stroke: what we learn from the MR CLEAN trial.
Authors: Sekhar A PMID: 25874830 [PubMed - in process]
Source: Journal of the Royal College of Physicians of Edinburgh - November 30, 2015 Category: Journals (General) Tags: J R Coll Physicians Edinb Source Type: research

FAST-IT: Find A Simple Test -- In TIA (transient ischaemic attack): a prospective cohort study to develop a multivariable prediction model for diagnosis of TIA through proteomic discovery and candidate lipid mass spectrometry, neuroimaging and machine learning--study protocol
Introduction Transient ischaemic attack (TIA) may be a warning sign of stroke and difficult to differentiate from minor stroke and TIA-mimics. Urgent evaluation and diagnosis is important as treating TIA early can prevent subsequent strokes. Recent improvements in mass spectrometer technology allow quantification of hundreds of plasma proteins and lipids, yielding large datasets that would benefit from different approaches including machine learning. Using plasma protein, lipid and radiological biomarkers, our study will develop predictive algorithms to distinguish TIA from minor stroke (positive control) and TIA-mimics (n...
Source: BMJ Open - April 1, 2022 Category: General Medicine Authors: Milton, A. G., Lau, S., Kremer, K. L., Rao, S. R., Mas, E., Snel, M. F., Trim, P. J., Sharma, D., Edwards, S., Jenkinson, M., Kleinig, T., Noschka, E., Hamilton-Bruce, M. A., Koblar, S. A. Tags: Open access, Health services research Source Type: research

Dl-3-n-butylphthalide alleviates cognitive impairment in amyloid precursor protein/presenilin 1 transgenic mice by regulating the striatal-enriched protein tyrosine phosphatase/ERK/cAMP-response element-binding protein signaling pathway
In conclusion, the present study provided evidence to suggest that the new drug NBP improved amyloid-induced learning and memory deficits, likely through the regulation of the STEP/ERK/CREB pathway. The results revealed that NBP, as a multi-target drug, may exert a neuroprotective effect. Therefore, NBP may serve as an effective treatment for AD.PMID:35350668 | PMC:PMC8943801 | DOI:10.3892/etm.2022.11248
Source: Experimental and Therapeutic Medicine - March 30, 2022 Category: General Medicine Authors: Yan Zhao Wen-Qiang Yang Lu Yu Jing Yang Hai-Rong Zhu Lin Zhang Source Type: research

Improvement of diagnostic performance of hyperacute ischemic stroke in head CT using an image-based noise reduction technique with non-black-boxed process
To date, a variety of image-based noise reduction (INR) techniques for computed tomography (CT) have been reported. They are based on iterative processes or deep learning techniques. Some INR products using iterative processes are already commercially available and have been reported to exhibit noise reduction performance better than hybrid-type iterative reconstruction (HIR) in abdominal CT [1,2]. However, the details of the processes inside these commercial INR systems are usually proprietary and cannot be readily replicated outside.
Source: Physica Medica: European Journal of Medical Physics - August 5, 2023 Category: General Medicine Authors: Tetsuya Hirairi, Katsuhiro Ichikawa, Atsushi Urikura, Hiroki Kawashima, Takasumi Tabata, Tamaki Matsunami Source Type: research