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Condition: Disability
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Total 350 results found since Jan 2013.
The Role of Progranulin (PGRN) in the Pathogenesis of Ischemic Stroke
Cell Mol Neurobiol. 2023 Aug 10. doi: 10.1007/s10571-023-01396-8. Online ahead of print.ABSTRACTStroke is a life-threatening medical condition and is a leading cause of disability. Cerebral ischemia is characterized by a distinct inflammatory response starting with the production of various cytokines and other inflammation-related agents. Progranulin (PGRN), a multifunctional protein, is critical in diverse physiological reactions, such as cell proliferation, inflammation, wound healing, and nervous system development. A mature PGRN is anti-inflammatory, while granulin, its derivative, conversely induces pro-inflammatory c...
Source: Cellular and Molecular Neurobiology - August 10, 2023 Category: Cytology Authors: Daryush Purrahman Ali Shojaeian Łukasz A Poniatowski Bart łomiej Piechowski-Jóźwiak Mohammad-Reza Mahmoudian-Sani Source Type: research
Identifying Neuroimaging Markers of Motor Disability in Acute Stroke by Machine Learning Techniques
In conclusion, multivariate fMRI analyses offer the potential to serve as markers for endophenotypes of functional impairment.
Source: Cerebral Cortex - August 14, 2015 Category: Neurology Authors: Rehme, A. K., Volz, L. J., Feis, D.- L., Bomilcar-Focke, I., Liebig, T., Eickhoff, S. B., Fink, G. R., Grefkes, C. Tags: Articles Source Type: research
Recurrent Alternating Homonymous Hemianopia Due to Mitochondrial Encephalomyopathy with Lactic Acidosis and Stroke-Like Episodes (MELAS) (P4.260)
CONCLUSIONS: We describe a unique phenomenon of recurrent alternating homonymous hemianopia in MELAS, which should prompt consideration of this diagnosis.Disclosure: Dr. Krysko has nothing to disclose. Dr. Arun has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Krysko, K., Arun, S. Tags: Neuro-ophthalmology/Neuro-otology Source Type: research
Combining Robotic & Assistive Technologies To Improve Outcomes: A Pilot Study Quantifying Stroke Rehabilitation
Stroke is the leading causes of long-term disability in the United States. Unfortunately, many survivors experience upper extremity (UE) impairment with few rehabilitation opportunities, secondary to a lack of voluntary muscle control. We developed a novel UE rehabilitation paradigm (TDS-HM) that uses a Tongue Drive System (TDS) to control a robotic device (HandMentor: HM), encouraging active learning through a game-like user interface. We hypothesize TDS-HM training will improve motor performance, reduce UE impairment, and improve quality of life in stroke survivors.
Source: Archives of Physical Medicine and Rehabilitation - September 24, 2017 Category: Rehabilitation Authors: Stephen Housley, David Wu, Kimberly Richards, Samir Belagaje, Maysam Ghovanloo, Andrew Butler Source Type: research
Proteomics-Guided Study on Buyang Huanwu Decoction for Its Neuroprotective and Neurogenic Mechanisms for Transient Ischemic Stroke: Involvements of EGFR/PI3K/Akt/Bad/14-3-3 and Jak2/Stat3/Cyclin D1 Signaling Cascades
AbstractBuyang Huanwu Decoction (BHD), a classic traditional Chinese medicine (TCM) formula, has been used for recovering neurological dysfunctions and treating post-stroke disability in China for 200 years. In the present study, we investigated the effects of BHD on inhibiting neuronal apoptosis, promoting proliferation and differentiation of neural stem cells (NSCs) and neurite formation and enhancing learning and memory functional recovery in an experimental rat ischemic stroke model. BHD si gnificantly reduced infarct volume and decreased cell apoptosis in the ischemic brain. BHD enhanced neuronal cell viability in v...
Source: Molecular Neurobiology - September 2, 2020 Category: Neurology Source Type: research
Exoskeleton-assisted Anthropomorphic Movement Training (EAMT) for Post-stroke Upper Limb Rehabilitation: A Pilot Randomized Controlled Trial
Stroke is the leading cause of mortality and disability worldwide, and it places a substantial burden on healthcare services and the socioeconomic system.1 More than two-thirds of individuals with stroke have upper extremity motor impairment and functional deficits at hospital admission,2, 3 manifesting as muscle weakness, loss of coordination and abnormal synergies.4 Moreover, upper limb dysfunction leads to long-term limitations in activities of daily living (ADL) and social participation.5 Extensive studies have reported that participants can benefit from high-intensity, task-specific training programs based on motor-le...
Source: Archives of Physical Medicine and Rehabilitation - June 23, 2021 Category: Rehabilitation Authors: Ze-Jian Chen, Chang He, Feng Guo, Cai-Hua Xiong, Xiao-Lin Huang Tags: Original Research Source Type: research
Comparing Poor and Favorable Outcome Prediction With Machine Learning After Mechanical Thrombectomy in Acute Ischemic Stroke
ConclusionsOur results suggest that a prediction of poor outcome after AIS and MT could be made based on clinical baseline variables only. Speed and extent of MT did improve prediction for a favorable outcome but is not relevant for poor outcome. An MR mismatch with small ischemic core and larger penumbral tissue showed no predictive importance.
Source: Frontiers in Neurology - May 27, 2022 Category: Neurology Source Type: research
Diagnostic model constructed by nine inflammation-related genes for diagnosing ischemic stroke and reflecting the condition of immune-related cells
ConclusionsTaken together, the diagnostic model constructed using the inflammation-related genes TNFSF10, ID1, PAQR8, OSR2, PDK4, PEX11B, TNIP1, FFAR2, and JUN exhibited high and specific diagnostic value for IS and reflected the condition of lymphocytes, monocytes, and neutrophils in the blood. The diagnostic model may contribute to the diagnosis of IS.
Source: Frontiers in Immunology - December 13, 2022 Category: Allergy & Immunology Source Type: research
