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Total 12254 results found since Jan 2013.
Large-Scale Phenome-Wide Association Study of PCSK9 Variants Demonstrates Protection Against Ischemic Stroke Original Articles
Conclusions:
This result represents the first genetic evidence in a large cohort for the protective effect of PCSK9 inhibition on ischemic stroke and corroborates exploratory evidence from clinical trials. PCSK9 inhibition was not associated with variables other than those related to LDL (low-density lipoprotein) cholesterol, atherosclerosis, and type 2 diabetes mellitus, suggesting that other effects are either small or absent.
Source: Circulation: Cardiovascular Genetics - July 11, 2018 Category: Cardiology Authors: Rao, A. S., Lindholm, D., Rivas, M. A., Knowles, J. W., Montgomery, S. B., Ingelsson, E. Tags: Cardiovascular Disease, Diabetes, Type 2, Genetic, Association Studies, Ischemic Stroke Original Articles Source Type: research
Re: Prognosis of Neurological Improvement in Inpatient Acute Ischemic Stroke Survivors: A Propensity Score Matching Snalysis
Wu Q and colleagues1 conducted a propensity-score (PS) matched study to identify prediction factors associated with short-term outcomes in patients with acute ischemic stroke survivors (improvement/ no improvement). In an effort to control for confounding, the authors matched on the propensity score to balance the National Institute of Health Stroke Scale (NIHSS) at admission between the two outcome groups. After matching, 92 pairs were analyzed in a multivariable outcome model of which two variables, diabetes and cognitive assessment, were identified as independent risk factors for the prognosis of neurological improvement.
Source: Journal of Stroke and Cerebrovascular Diseases - April 22, 2021 Category: Neurology Authors: Rania A Mekary, Jiping Zhou, Tobias Kurth Tags: Letter to the Editor Source Type: research
Gut Microbiota in Ischemic Stroke: Role of Gut Bacteria-Derived Metabolites
AbstractIschemic stroke (IS) remains a leading cause of death and long-term disability globally. Several mechanisms including glutamate excitotoxicity, calcium overload, neuroinflammation, oxidative stress, mitochondrial damage, and apoptosis are known to be involved in the pathogenesis of IS, but the underlying pathophysiology mechanisms of IS are not fully clarified. During the past decade, gut microbiota were recognized as a key regulator to affect the health of the host either directly or via their metabolites. Recent studies indicate that gut bacterial dysbiosis is closely related to hypertension, diabetes, obesity, d...
Source: Translational Stroke Research - October 24, 2022 Category: Neurology Source Type: research
Cardiovascular Risk Profile and Cognitive Function in Young, Middle-Aged, and Elderly Subjects Clinical Sciences
Conclusions—
In this large population–based cohort, a worse overall cardiovascular risk profile was associated with poorer cognitive function. This association was already present in young adults aged 35 to 44 years.
Source: Stroke - May 24, 2013 Category: Neurology Authors: Joosten, H., van Eersel, M. E. A., Gansevoort, R. T., Bilo, H. J. G., Slaets, J. P. J., Izaks, G. J. Tags: Cerebrovascular disease/stroke, Risk Factors, Epidemiology Clinical Sciences Source Type: research
Mediterranean diet 'reduces genetic stroke risk'
Scientists say they have discovered that the Mediterranean diet may prevent a genetic risk of stroke since it appears to interact with a particular gene variant usually associated with type 2 diabetes. Researchers from the Jean Mayer USDA Human Nutrition Research center on Aging (USDA HNRCA) at Tufts University, and the CIBER FisiopatologÃa de la Obesidad y NutriciÏ�n in Spain, conducted the study, which was published in the journal Diabetes Care. The research team analyzed 7,018 men and women involved in the Prevencion con Dieta Mediterranea (PREDIMED) trial...
Source: Health News from Medical News Today - August 15, 2013 Category: Consumer Health News Tags: Stroke Source Type: news
Nascent Lobar Microbleeds and Stroke Recurrences
Conclusions: Though a cohort study limited the power of analyses, our findings suggested that lobar MBs might be associated with deep ICH.
Source: Journal of Stroke and Cerebrovascular Diseases - June 24, 2013 Category: Neurology Authors: Toshio Imaizumi, Shigeru Inamura, Ikuhide Kohama, Kazuhisa Yoshifuji, Tatsufumi Nomura, Katsuya Komatsu Tags: Original Articles Source Type: research
Non-vitamin-K oral anticoagulants reduce mortality, stroke and intracranial haemorrhage when compared with warfarin in randomised trials of patients with non-valvular atrial fibrillation
Commentary on: Ruff CT, Giugliano RP, Braunwald E, et al.. Comparison of the efficacy and safety of new oral anticoagulants with warfarin in patients with atrial fibrillation: a meta-analysis of randomised trials. Lancet 2014;383:955–62. Context Historically, the standard medication for stroke prevention in atrial fibrillation (AF) has been a vitamin-K antagonist (warfarin). However, several non-vitamin-K oral anticoagulants (NOACs) have been developed and shown to be at least as effective as dose-adjusted warfarin in their respective phase-3 clinical trials.1–4 These include the direct thrombin inhibitor dabig...
Source: Evidence-Based Medicine - September 15, 2014 Category: Internal Medicine Authors: Steinberg, B. A. Tags: Epidemiologic studies, Drugs: cardiovascular system, Stroke, Ischaemic heart disease, Connective tissue disease, Musculoskeletal syndromes, Diabetes, Arrhythmias Therapeutics Source Type: research
Duration of Diabetes Mellitus and Risk of Thromboembolism and Bleeding in Atrial Fibrillation: Nationwide Cohort Study Clinical Sciences
Conclusions—
In patients with atrial fibrillation, longer duration of diabetes mellitus was associated with a higher risk of thromboembolism, but not with a higher risk of anticoagulant-related bleeding. Considering the critical balance between preventing thromboembolism and avoiding bleeding, longer duration of diabetes mellitus may favor initiation of anticoagulant therapy.
Source: Stroke - July 27, 2015 Category: Neurology Authors: Overvad, T. F., Skjoth, F., Lip, G. Y. H., Lane, D. A., Albertsen, I. E., Rasmussen, L. H., Larsen, T. B. Tags: Thrombosis risk factors, Type 1 diabetes, Type 2 diabetes, Embolic stroke, Anticoagulants Clinical Sciences Source Type: research
Prevalence and Risk Factors of Acute Incidental Infarcts Clinical Sciences
Conclusions—
AII are more likely to be present in those with cognitive impairment. Although a cause–effect relationship between the presence of AII and cognitive impairment is plausible, the association may be because of under-reporting of symptoms by individuals with cognitive impairment. The association between AII and cerebral microbleeds may indicate cerebral vasculopathy, independent of traditional vascular risk factors.
Source: Stroke - September 28, 2015 Category: Neurology Authors: Saini, M., Suministrado, M. S. P., Hilal, S., Dong, Y. H., Venketasubramanian, N., Ikram, M. K., Chen, C. Tags: Acute Stroke Syndromes Clinical Sciences Source Type: research
Periprocedural Myocardial Infarction After Carotid Endarterectomy and Stenting: Systematic Review and Meta-Analysis Clinical Sciences
Conclusions—
The risk of MI after CEA and CAS did not significantly differ. Risk factors for MI are overall similar in both techniques except that men are at lower risk of MI after CAS but not after CEA.
Source: Stroke - September 28, 2015 Category: Neurology Authors: Boulanger, M., Cameliere, L., Felgueiras, R., Berger, L., Rerkasem, K., Rothwell, P. M., Touze, E. Tags: Acute myocardial infarction, Carotid Stenosis, Primary and Secondary Stroke Prevention, Carotid endarterectomy, Angioplasty and Stenting Clinical Sciences Source Type: research
Type 2 Diabetes and Hemorrhagic Stroke: A Population-Based Study in Spain from 2003 to 2012
The objective of this study is to compare trends in outcomes for intracerebral hemorrhagic stroke in people with or without type 2 diabetes in Spain between 2003 and 2012.
Source: Journal of Stroke and Cerebrovascular Diseases - March 22, 2016 Category: Neurology Authors: Nuria Muñoz-Rivas, Manuel Méndez-Bailón, Valentín Hernández-Barrera, José Mª de Miguel-Yanes, Rodrigo Jimenez-Garcia, Jesus Esteban-Hernández, Ana Lopez-de-Andrés Source Type: research
Glycosylated Hemoglobin and Functional Outcome after Acute Ischemic Stroke
Diabetes mellitus (DM) is associated to an increased incidence of cerebral and myocardial infarction which could be reduced by long-term maintenance of optimal glycemic values. The aim of the study was to evaluate in diabetic patients with ischemic stroke the chronic glycemic status and its relationship with functional outcome.
Source: Journal of Stroke and Cerebrovascular Diseases - April 17, 2016 Category: Neurology Authors: Simona Lattanzi, Marco Bartolini, Leandro Provinciali, Mauro Silvestrini Source Type: research
Association between Ischemic Stroke and Erdheim –Chester Disease: A Case Report and Review of Literature
We report the case of a 68-year-old woma n who presented with an acute ischemic stroke associated with a multisystemic disorder including insipidus diabetes, infiltration of the aorta and the carotid arteries, perirenal infiltration, aortitis, and lytic bone lesions.
Source: Journal of Stroke and Cerebrovascular Diseases - June 13, 2017 Category: Neurology Authors: Guillaume Fargeot, Sabrina Stefanizzi, Sebastien Depuydt, Frederic Klapczynski, Alain Ameri Tags: Case Studies Source Type: research
Acute Stroke Patients with Newly Diagnosed Diabetes Mellitus Have Poorer Outcomes than Those with Previously Diagnosed Diabetes Mellitus
This study aims to determine the prevalence of NDDM in the ASPs and to compare the outcome in NDDM and previously diagnosed DM (PDDM) in Cameroon.
Source: Journal of Stroke and Cerebrovascular Diseases - May 18, 2018 Category: Neurology Authors: Yacouba Njankouo Mapoure, Hamadou Ba, Chia Mark Ayeah, Caroline Kenmegne, Henry Namme Luma, Alfred Kongnyu Njamnshi Source Type: research
