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Total 13659 results found since Jan 2013.

Proteinuria Predicts Resistance to Antiplatelet Therapy in Ischemic Stroke
AbstractThe occurrence of a stroke while on antiplatelet agents presents a therapeutic dilemma. One of the main causes for recurrent strokes is antiplatelet resistance more commonly known as high on treatment platelet reactivity (HTPR). Prior studies have established that proteinuria is associated with HTPR following myocardial infarction. Here, we investigated whether dipstick proteinuria correlates with HTPR in patients presenting with stroke. We performed a retrospective cohort analysis of 102 patients admitted for a recurrent ischemic stroke that had either a VerifyNow aspirin or VerifyNow clopidogrel laboratory test p...
Source: Translational Stroke Research - September 5, 2017 Category: Neurology Source Type: research

Short-Term Acute Exercise Preconditioning Reduces Neurovascular Injury After Stroke Through Induced eNOS Activation
AbstractPhysical exercise is known to reduce cardiovascular risk but its role in ischemic stroke is not clear. It was previously shown that an acute single bout of exercise reduced increased eNOS activation in the heart and reduced myocardial infarction. However, the impact of a single bout or short-term exercise on eNOS-induced neuroprotection after stroke was not previously studied. Accordingly, this study was designed to test the hypothesis that short-term acute exercise can provide “immediate neuroprotection” and improve stroke outcomes through induced eNOS activation. Male Wistar rats (300 g) were subjected to HI...
Source: Translational Stroke Research - December 19, 2019 Category: Neurology Source Type: research

Endovascular treatment for acute ischemic stroke in octogenarians compared with younger patients: a meta‐analysis
ConclusionFormal meta‐analysis showed that octogenarians are less likely to achieve functional independence and have higher rates of mortality and intracerebral hemorrhage following endovascular treatment for ischemic stroke compared with younger patients. Decisions regarding endovascular treatment of elderly patients should be individualized until randomized controlled trials are available.
Source: International Journal of Stroke - August 26, 2013 Category: Neurology Authors: E. Jesús Duffis, Wenzhuan He, Charles J. Prestigiacomo, Chirag D. Gandhi Tags: Research Source Type: research

Patients' and ambulance service clinicians' experiences of prehospital care for acute myocardial infarction and stroke: a qualitative study
Conclusions Factors that contribute to better patient experience are not necessarily understood in the same way by patients and clinicians. Our findings can contribute to the development of patient experience measures for prehospital care.
Source: Emergency Medicine Journal - October 18, 2013 Category: Emergency Medicine Authors: Togher, F. J., Davy, Z., Siriwardena, A. N. Tags: Drugs: cardiovascular system, Stroke, Acute coronary syndromes, Resuscitation Prehospital care Source Type: research

Warfarin versus Aspirin for Prevention of Stroke in Heart Failure: A Meta-analysis of Randomized Controlled Clinical Trials
Conclusions: Compared with aspirin, warfarin reduced the risk of stroke while conferring an increased risk of major hemorrhage. Warfarin does not increase mortality or confer an increased risk of ICH compared with aspirin.
Source: Journal of Stroke and Cerebrovascular Diseases - November 21, 2012 Category: Neurology Authors: Gyanendra Kumar, Munish Kumar Goyal Tags: Original Articles Source Type: research

Troponin Elevation in Intra-arterial Stroke Intervention (P4.211)
CONCLUSIONS: Aggressive treatment may increase the risk of troponin elevation without increasing mortality in AIS patients. This finding is reassuring in view of continued interest in IA treatment of stroke in addition to tPA thrombolysis.Disclosure: Dr. Kumar has nothing to disclose. Dr. Mehta has nothing to disclose. Dr. Alawi has nothing to disclose. Dr. Michael has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Kumar, A., Mehta, S., Alawi, A., Michael, A. Tags: Cerebrovascular Disease and Interventional Neurology: Acute Stroke Endovascular Source Type: research

Meta-analysis finds benefit for dual antiplatelet therapy but limitations preclude changing standard mono antiplatelet therapy approach for acute non-cardioembolic ischaemic stroke or transient ischaemic attack
Commentary on: Wong KSL, Wang Y, Leng X, et al.. Early dual versus mono antiplatelet therapy for acute non-cardioembolic ischemic stroke or transient ischemic attack. An updated systematic review and meta-analysis. Circulation 2013;128:1656–66. Context Current guidelines recommend aspirin, aspirin plus clopidogrel or aspirin plus extended-release dipyridamole for treatment of acute ischaemic stroke (IS) or transient ischaemic attack (TIA) to prevent recurrent stroke, myocardial infarction and cardiovascular death.1 The Clopidogrel in High-risk patients with Acute Non-disabling Cerebrovascular Events (CHANCE) trial ra...
Source: Evidence-Based Medicine - May 19, 2014 Category: Internal Medicine Authors: Aronow, W. S. Tags: Clinical trials (epidemiology), Epidemiologic studies, Drugs: cardiovascular system, Stroke, Ischaemic heart disease Therapeutics Source Type: research

Impaired Renal Function in Stroke Patients with Atrial Fibrillation
In this study, we analyzed frequency and predictors for impaired renal function and its impact on functional outcome in stroke patients with underlying AF.Methods: We analyzed 272 patients with acute ischemic stroke and AF of our prospective, observational stroke database. Estimated glomerular filtration rate (eGFR) was calculated on admission and during hospitalization from the equation of the Modification Diet for Renal Disease. Outcome measures included mortality and functional outcome at 90 days, assessed as modified Rankin Scale (mRS) score.Results: On admission, impaired renal function was found in 41.5% (n = 113)...
Source: Journal of Stroke and Cerebrovascular Diseases - November 25, 2013 Category: Neurology Authors: Eva-Maria Sauer, Roland Sauer, Bernd Kallmünzer, Christian Blinzler, Lorenz Breuer, Hagen B. Huttner, Stefan Schwab, Martin Köhrmann Tags: Original Articles Source Type: research

Impact of living and socioeconomic characteristics on cardiovascular risk in ischemic stroke patients
ConclusionVascular risk in stroke patients in low‐ and middle‐income countries varies not only with the number of arterial beds involved but also with socioeconomic variables.
Source: International Journal of Stroke - June 13, 2014 Category: Neurology Authors: Pierre Amarenco, Halim Abboud, Julien Labreuche, Antonio Arauz, Alan Bryer, Pablo M. Lavados, Ayrton Massaro, Mario Munoz Collazos, Philippe Gabriel Steg, Bassem I. Yamout, Eric Vicaut, Tags: Research Source Type: research

Likelihood of myocardial infarction during stroke rehabilitation preceded by cardiovascular screening and an exercise tolerance test: the Locomotor Experience Applied Post‐Stroke (LEAPS) Trial
ConclusionsThe combination of a negative cardiac screen and the absence of exercise tolerance test failure appeared to have a high negative predictive value for cardiac events during treatment, despite the likelihood of a high prevalence of coronary artery disease in our population.
Source: International Journal of Stroke - August 26, 2014 Category: Neurology Authors: Stephen E. Nadeau, Dorian Kay Rose, Bruce Dobkin, Samuel S. Wu, Yufeng E. Dai, Richard Schofield, Pamela W. Duncan, Tags: Research Source Type: research

Recurrent vascular events in lacunar stroke patients with metabolic syndrome and/or diabetes
Conclusion: METS and DM were significant comorbid conditions in lacunar stroke patients and they were associated with stroke recurrence. In patients with lacunar infarcts, a vigilant approach to prevent development of DM in those with METS may be a potential strategy to reduce recurrent strokes.
Source: Neurology - September 14, 2015 Category: Neurology Authors: Zhu, S., McClure, L. A., Lau, H., Romero, J. R., White, C. L., Babikian, V., Nguyen, T., Benavente, O. R., Kase, C. S., Pikula, A. Tags: All Cerebrovascular disease/Stroke ARTICLE Source Type: research

A meta-analysis investigating incidence and features of stroke in HIV-infected patients in the highly active antiretroviral therapy era
Conclusion: Stroke represents a relatively common complication in young, HAART-treated HIV patients. Apart from traditional cardiovascular risk factors, HIV-RNA viral load may help to target and manage patients at risk.
Source: Journal of Cardiovascular Medicine - October 30, 2015 Category: Cardiology Tags: Stroke in HIV Source Type: research

Recurrent Stroke, Myocardial Infarction, and Major Vascular Events during the First Year after Acute Ischemic Stroke: The Multicenter Prospective Observational Study about Recurrence and Its Determinants after Acute Ischemic Stroke I
Patients with acute ischemic stroke (AIS) are at high risk of subsequent vascular events. The aim of this study was to estimate rates of recurrent stroke, myocardial infarction (MI), and major vascular events during the first year after AIS in Korea.
Source: Journal of Stroke and Cerebrovascular Diseases - December 29, 2015 Category: Neurology Authors: Kyusik Kang, Tai Hwan Park, Nayoung Kim, Min Uk Jang, Sang-Soon Park, Jong-Moo Park, Youngchai Ko, SooJoo Lee, Kyung Bok Lee, Jun Lee, Dong-Eog Kim, Yong-Jin Cho, Joon-Tae Kim, Dae-Hyun Kim, Jae-Kwan Cha, Moon-Ku Han, Ji Sung Lee, Juneyoung Lee, Mi Sun Oh Source Type: research

PCSK9 Loss-of-Function Variants, Low-Density Lipoprotein Cholesterol, and Risk of Coronary Heart Disease and Stroke: Data From 9 Studies of Blacks and Whites Original Articles
Conclusions— PCSK9 LOF variants were associated with lower LDL-C and coronary heart disease incidence. PCSK9 LOF variants were not associated with stroke risk.
Source: Circulation: Cardiovascular Genetics - August 2, 2017 Category: Cardiology Authors: Kent, S. T., Rosenson, R. S., Avery, C. L., Chen, Y.-D. I., Correa, A., Cummings, S. R., Cupples, L. A., Cushman, M., Evans, D. S., Gudnason, V., Harris, T. B., Howard, G., Irvin, M. R., Judd, S. E., Jukema, J. W., Lange, L., Levitan, E. B., Li, X., Liu, Tags: Lipids and Cholesterol, Genetic, Association Studies, Myocardial Infarction, Meta Analysis, Cerebrovascular Disease/Stroke Original Articles Source Type: research

Cerebrovascular Outcomes With Proton Pump Inhibitors and Thienopyridines Clinical Sciences
Background and Purpose—Pharmacokinetic and prior studies on thienopyridine and proton pump inhibitors (PPI) coadministration provide conflicting data for cardiovascular outcomes, whereas there is no established evidence on the association of concomitant use of PPI and thienopyridines with adverse cerebrovascular outcomes.Methods—We conducted a systematic review and meta-analysis of randomized controlled trials and cohort studies from inception to July 2017, reporting following outcomes among patients treated with thienopyridine and PPI versus thienopyridine alone (1) ischemic stroke, (2) combined ischemic or hemorrhagi...
Source: Stroke - January 22, 2018 Category: Neurology Authors: Konark Malhotra, Aristeidis H. Katsanos, Mohammad Bilal, Muhammad Fawad Ishfaq, Nitin Goyal, Georgios Tsivgoulis Tags: Meta Analysis, Ischemic Stroke Original Contributions Source Type: research