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Cardiovascular and mortality risks in Parkinson's disease patients treated with entacapone
ABSTRACT The controlled trial Stalevo Reduction in Dyskinesia Evaluation in Parkinson's Disease (STRIDE‐PD) reported an unexpected increase in acute myocardial infarction (AMI) with entacapone use in patients with Parkinson's disease (PD). The authors investigated whether entacapone increased cardiovascular and mortality risk compared with the use of a non‐levodopa dopamine agonist (DA) or a selective monoamine oxidase type‐B inhibitor (MAOBI). Using national Medicare data, a new‐user cohort of elderly patients with PD treated with entacapone was propensity score (PS) matched with new users of either DA or MAOBI. T...
Source: Movement Disorders - February 26, 2013 Category: Neurology Authors: David J. Graham, James R. Williams, Ya‐Hui Hsueh, Katlyn Calia, Mark Levenson, Simone P. Pinheiro, Thomas E. MaCurdy, David Shih, Chris Worrall, Jeffrey A. Kelman Tags: Research Article Source Type: research

Blood-brain barrier permeability in association with levodopa-induced dyskinesia in Parkinson's disease: a rubidium-82 PET study
Conclusion: The findings do not support the presence of significant alterations in BBB permeability in PD patients with or without LID. Research Support: This work was supported by the National Institute of Neurological Disorders and Stroke Morris K. Udall Center of Excellence for Parkinson’s Disease Research at The Feinstein Institute for Medical Research (P50 NS071675 to the last author).
Source: Journal of Nuclear Medicine - May 24, 2017 Category: Nuclear Medicine Authors: Fujita, K., Dhawan, V., Peng, S., Ma, Y., Eidelberg, D. Tags: New Approaches to Image Parkinson Syndrome Source Type: research

Sensory Re-weighting for Postural Control in Parkinson ’s Disease
In this study, we focused primarily on the change of sensory weighting parameters when sensory conditions change. We also tested the additional hypothesis that levodopa medication would improve sensory weighting for postural control. Materials and Methods Subjects The Institutional Review Board at Oregon Health and Science University (OHSU) approved the protocol for this experiment, and all subjects gave informed consent prior to participating. Eight subjects with PD (three female) and eight healthy, age-matched controls (two female) were recruited from the Balance Disorders Laboratory database and the Parkinson’...
Source: Frontiers in Human Neuroscience - April 16, 2019 Category: Neuroscience Source Type: research

Dystonia and levodopa-induced dyskinesias in Parkinson's disease: Is there a connection?
Abstract Dystonia and levodopa-induced dyskinesia (LID) are both hyperkinetic movement disorders. Dystonia arises most often spontaneously, although it may be seen after stroke, injury, or as a result of genetic causes. LID is associated with Parkinson's disease (PD), emerging as a consequence of chronic therapy with levodopa, and may be either dystonic or choreiform. LID and dystonia share important phenomenological properties and mechanisms. Both LID and dystonia are generated by an integrated circuit involving the cortex, basal ganglia, thalamus and cerebellum. They also share dysregulation of striatal choliner...
Source: Neurobiology of Disease - August 20, 2019 Category: Neurology Authors: Calabresi P, Standaert DG Tags: Neurobiol Dis Source Type: research