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Specialty: Endocrinology
Drug: Estradiol

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Total 33 results found since Jan 2013.

In older men, higher plasma testosterone or dihydrotestosterone are independent predictors for reduced incidence of stroke but not myocardial infarction.
Conclusions: Higher plasma T or DHT are biomarkers for reduced risk of stroke but not MI. Androgen exposure may influence outcomes following rather than incidence of MI, while androgens but not E2 are independent predictors of stroke risk. Randomised clinical trials are needed to clarify the impact of modifying T or DHT on the risk of stroke in ageing men. PMID: 25268392 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - September 30, 2014 Category: Endocrinology Authors: Yeap BB, Alfonso H, Paul Chubb SA, Hankey GJ, Handelsman DJ, Golledge J, Almeida OP, Flicker L, Norman PE Tags: J Clin Endocrinol Metab Source Type: research

Sex Differences in the Impact of Shift Work Schedules on Pathological Outcomes in an Animal Model of Ischemic Stroke.
Abstract Circadian clock desynchronization has been implicated in the pathophysiology of cardiovascular disease and related risk factors (e.g., obesity, diabetes). Thus, we examined the extent to which circadian desynchronization exacerbates ischemic stroke outcomes and whether its detrimental effects on stroke severity and functional impairments are further modified by biological sex. Circadian entrainment of activity rhythms in all male and female rats was observed during exposure to a fixed light:dark (LD) 12:12 cycle but was severely disrupted when this LD cycle was routinely shifted (12hr advance/5d) for ≈ ...
Source: Endocrinology - June 1, 2016 Category: Endocrinology Authors: Earnest DJ, Neuendorff N, Coffman J, Selvamani A, Sohrabji F Tags: Endocrinology Source Type: research

Selective Non-nuclear Estrogen Receptor Activation Decreases Stroke Severity and Promotes Functional Recovery in Female Mice.
Abstract Estrogens provide neuroprotection in animal models of stroke, but uterotrophic effects and cancer risk limit translation. Classical estrogen receptors (ER) serve as transcription factors, whereas non-nuclear ER govern numerous cell processes and exert beneficial cardiometabolic effects without uterine or breast cancer growth in mice. Here we determined how non-nuclear ER stimulation with a pathway-preferential estrogen (PaPE-1) impacts stroke outcome in mice.Ovariectomized female mice received vehicle, estradiol (E2), or PaPE-1 before and following transient middle cerebral artery occlusion (tMCAo). MRI a...
Source: Endocrinology - September 25, 2018 Category: Endocrinology Authors: Selvaraj UM, Zuurbier K, Whoolery C, Plautz EJ, Chambliss KL, Kong X, Zhang S, Kim SH, Katzenellenbogen BS, Katzenellenbogen JA, Mineo C, Shaul PW, Stowe AM Tags: Endocrinology Source Type: research

Estrogen-IGF-1 interactions in neuroprotection: Ischemic Stroke as a case study.
Abstract The steroid hormone 17b-estradiol and the peptide hormone insulin-like growth factor (IGF)-1 independently exert neuroprotective actions in neurologic diseases such as stroke. Only a few studies have directly addressed the interaction between the two hormone systems, however, there is a large literature that indicates potentially greater interactions between the 17b-estradiol and IGF-1 systems. The present review focuses on key issues related to this interaction including IGF-1 and sex differences and common activation of second messenger systems. Using ischemic stroke as a case study, this review also fo...
Source: Frontiers in Neuroendocrinology - May 29, 2014 Category: Endocrinology Authors: Sohrabji F Tags: Front Neuroendocrinol Source Type: research

Oral contraceptives and stroke: Foes or friends
Front Neuroendocrinol. 2022 Jul 20:101016. doi: 10.1016/j.yfrne.2022.101016. Online ahead of print.ABSTRACTIncidents of strokes are increased in young women relative to young men, suggesting that oral contraceptive (OC) use is one of the causes of stroke among young women. Long-term exposures to the varying combinations of estrogen and progestogen found in OCs affect blood clotting, lipid and lipoprotein metabolism, endothelial function, and de novo synthesis of neurosteroids, especially brain-derived 17β-estradiol. The latter is essential for neuroprotection, memory, sexual differentiation, synaptic transmission, and beh...
Source: Frontiers in Neuroendocrinology - July 23, 2022 Category: Endocrinology Authors: Varun Reddy Megan Wurtz Shahil H Patel Micheline McCarthy Ami P Raval Source Type: research

Sex hormones and ischemic stroke: a prospective cohort study and meta-analyses.
CONCLUSIONS: Extreme low endogenous testosterone concentrations were associated with high risk of IS in men, a risk mediated in part by body mass index and hypertension. Whether or not low testosterone is a causal factor for IS or merely a biomarker of poor metabolic health is still not known. PMID: 26509870 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - October 28, 2015 Category: Endocrinology Authors: Holmegard HN, Nordestgaard BG, Jensen GB, Tybjærg-Hansen A, Benn M Tags: J Clin Endocrinol Metab Source Type: research

Neuroactive Steroids in Acute Ischemic Stroke: Association with Cognitive, Functional, and Neurological Outcomes
Horm Metab Res DOI: 10.1055/s-0042-119201Despite several scientific and technological advances, there is no single neuroprotective treatment that can reverse the brain damage after acute ischemic stroke (AIS). Neuroactive steroids are cholesterol-derived hormones that have the ability to modulate the normal and pathologic nervous system employing genomic and nongenomic mechanisms. In this work, we first investigated if AIS affects the plasma concentration of 5 neuroactive steroids (cortisol, estradiol, progesterone, testosterone, and 3α-androstenediol glucuronide). Second, we studied if levels of circulating steroids asso...
Source: Hormone and Metabolic Research - November 2, 2016 Category: Endocrinology Authors: Casas, S. Gonzalez Deniselle, M. C. Gargiulo-Monachelli, G. M. Perez, A. F. Tourreilles, M. Mattiazzi, M. Ojeda, C. Lotero Polesel, D. G. De Nicola, A. F. Tags: Endocrine Care Source Type: research