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Retrospective cohort study investigating synergism of air pollution and corticosteroid exposure in promoting cardiovascular and thromboembolic events in older adults
Conclusion PM2.5 and systemic corticosteroid use were independently associated with increases in CTE hospitalisations. We also found evidence of significant additive interactions between the two exposures for HF and MI/ACSs suggesting synergy between these two exposures.
Source: BMJ Open - September 13, 2023 Category: General Medicine Authors: Josey, K., Nethery, R., Visaria, A., Bates, B., Gandhi, P., Parthasarathi, A., Rua, M., Robinson, D., Setoguchi, S. Tags: Open access, Epidemiology Source Type: research

Benefits of Pulmonary Vein Isolation Beyond Rhythm Control
The prevalence of atrial fibrillation (AF) is continually increasing, with major implications for patients and health care systems given the increased morbidity and mortality. Approximately one-third of patients with AF additionally are affected by mental health conditions (notably depression, anxiety, and perceived stress). Psychological distress conditions are independent risk factors for adverse cardiovascular outcomes (including stroke and major bleeding) in patients with AF and promote AF recurrence. Without doubt, these associations add more complexity to comprehensive treatment decisions for patients with AF.
Source: JAMA - September 12, 2023 Category: General Medicine Source Type: research

Incidence of atrial fibrillation in cryptogenic stroke with patent foramen ovale closure: protocol for the prospective, observational PFO-AF study
Introduction After closure of patent foramen ovale (PFO) due to stroke, atrial fibrillation (AF) occurs in up to one in five patients. However, data are sparse regarding the possible pre-existence of AF in these patients prior to PFO closure, and about recurrence of AF in the long term after the procedure. No prospective study to date has investigated these topics in patients with implanted cardiac monitor (ICM). The PFO-AF study (registered with ClinicalTrials.gov under the number NCT04926142) will investigate the incidence of AF occurring within 2 months after percutaneous closure of PFO in patients with prior stroke. AF...
Source: BMJ Open - September 12, 2023 Category: General Medicine Authors: Badoz, M., Derimay, F., Serzian, G., Besutti, M., Rioufol, G., Frey, P., Guenancia, C., Ecarnot, F., Meneveau, N., Chopard, R. Tags: Open access, Cardiovascular medicine Source Type: research

Serum biomarkers to predict hemorrhagic transformation and ischemic stroke outcomes in a prospective cohort study
This study aimed to investigate the potential prognosis role of non-specific laboratory data at admission and baseline MMP-2 and MMP-9 serum levels in predicting HT risk, discharge, and 3-month follow-up status of IS patients. Data from 150 successive acute cerebral infarction patients were analyzed in a prospective cohort study. The active group included patients who developed HT during hospitalization (55 persons). There were no significant differences in age, gender distribution, time to admission, or time to blood sample collection for MMPs measurement between patients in the active and control groups. IS patients from...
Source: Journal of Medicine and Life - September 7, 2023 Category: General Medicine Authors: Elena Costru-Tasnic Mihail Gavriliuc Elena Manole Source Type: research

Temporal trends of hypertrophic cardiomyopathy in Denmark: a nationwide retrospective cohort study
Conclusion There was a consistent rise in HCM cases with decreasing morbidity burden. Females were older at diagnosis and more likely to have their type of HCM classified as obstructive. The rate of outpatient follow-up is increasing.
Source: BMJ Open - September 4, 2023 Category: General Medicine Authors: Zörner, C. R., Pallisgaard, J., Schjerning, A.-M., Jensen, M. K., Tonnesen, J., Da Riis-Vestergaard, L., Middelfart, C., Rasmussen, P. V., Gislason, G., Hansen, M. L. Tags: Open access, Cardiovascular medicine Source Type: research

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