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Controversies over the impact of the COVID-19 pandemic on patients with Pulmonary Arterial Hypertension
This study is a retrospective analysis of our PAH patients treated in 2020 compared to the dynamics of the last 12 years. We had 48 PAH patients, 51.72±16.64 years, 72.91% female. All patients had chronic anticoagulant therapy(58.33%) and/or antiplatelet; 33.33% had long term oxygen therapy. Three patients with secondary forms were confirmed with COVID-19, all hospitalized (6.25% infection rate versus 3.29% in general). One patient died(75 years with scleroderma, stroke), two patients were cured (mild forms). In total only three patients died in 2020. Surprisingly, compared with 2008-2019 (101 patients/ 41 deaths, 3...
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Bertici, N. S., Dobrescu, L., Pislaru, L., Marincu, I. Tags: Pulmonary hypertension Source Type: research

Thromboembolic events in COVID-19 patients : A Tunisian case series study
Coronavirus disease 2019 (COVID-19) can lead to systemic coagulation activation and thrombotic complications(TC), which may lead to fatal outcomes if not diagnosed and managed appropriately.We aimed to report the incidence and characteristics of venous and arterial thrombotic complications(TC) in hospitalized patients with COVID-19 and to investigate the predictive factors of their occurrence.A retrospective study including 200 patients with COVID-19 confirmed by a reverse transcription polymerase chain reaction test, admitted between March 2020 and January 2021 in the pulmonary departement B at Abderrahman Mami Hospi...
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Louhaichi, S., Ferchichi, M., Khalfallah, I., Belkhir, S., Boubaker, N., Ammar, J., Hamdi, B., Hamzaoui, A. Tags: Respiratory infections and bronchiectasis Source Type: research

Risk assessment of systemic sclerosis-associated pulmonary arterial hypertension: cardiac index versus stroke volume index
Pulmonary arterial hypertension (PAH) frequently complicates systemic sclerosis (SSc), with an estimated prevalence of 6.4–9% [1, 2]. Although survival has improved with the advent of PAH-specific therapy, SSc-PAH continues to have poor prognosis, with a 3-year survival of 67% [3]. Current PAH management guidelines highlight the importance of risk stratification in guiding therapy [4].
Source: European Respiratory Journal - September 15, 2022 Category: Respiratory Medicine Authors: Hassan, H. J., Naranjo, M., Kazzi, B., Housten-Harris, T., Hsu, S., Balasubramanian, A., Simpson, C. E., Damico, R. L., Kolb, T. M., Mathai, S. C., Hassoun, P. M. Tags: Research letters Source Type: research

Impact of cardiovascular disease on in-hospital mortality in patients with COVID-19
Conclusion: COVID-19 patients with CVD comorbidites have a higher risk of in-hospital death. Optimal care and good control of CVD are essential in this patient group.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Pencheva Genova, V., Pancheva, R., Stoimenov, B., Manov, E., Kolev, V., Tsrancheva, R., Koshtikova, K., Stoianov, D., Donev, S. Tags: 01.01 - Clinical problems - no related to asthma or COPD Source Type: research

COPD and COVID-19: a dangerous association?
Conclusion: COPDs patients are mostly ederly men with comorbidities. The most effective treatment for them was stabilization of comorbidities and conventional oxygen and for the most severe Helmet-CPAP and NIV. In addition, COPD patients had no higher risk of mortality from COVID-19 than individuals without a pre-existing diagnosis of COPD.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Mendez Gonzalez, L., Ferreira, J., Caneiras, C. Tags: 05.02 - Monitoring airway disease Source Type: research

Comorbidities in patients with Obstructive Sleep Apnea syndrome (OSAS) in Reunion Island.
Conclusion: Morbid obesity, hypertension, diabetes, heart disease and respiratory illness are a predictor of severe OSAS in our patients especially snorers.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Omarjee, B., Budhan, S., Kichenin, C., Omarjee, A., Vellin, J. F. Tags: 01.01 - Clinical problems - no related to asthma or COPD Source Type: research

Prevalence of cardiovascular disease in alpha-1 antrypsin deficiency
We present prevalence of CVD from 1158 patients with AATD who are prospectively followed up as part of the Birmingham AATD registry in the UK. All diagnoses come from either central NHS records or patient reports.The prevalence of CVD was as follows: ischaemic heart disease, 5.2%; heart failure, 0.7%, myocardial infarction, 0.9%; stroke, 1.9%; atrial fibrillation 2.4%. Hypertension and hyperlipidaemia were present in 22% and 10.7% of patients respectively. Factors associated with a higher prevalence of CVD include being male (p <0.001), older age (p <0.001), lower KCO (p = 0.008) and presence of hyperlipidaemia ...
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Bailey, E., Ellis, P., Turner, A., Ellis, P. Tags: 05.02 - Monitoring airway disease Source Type: research

Predictive factors of mechanical ventilation among critically ill adults with COVID-19
Conclusion: Among ICU admitted patients, comorbidities, neurological symptoms, elevated rate of D-dimer and CRP and important radiological damage are the main risk factors for requiring IMV.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Jribi, B., Omrane, L., Mjid, M., Chaieb, A., Jebali, R., Hedhli, A., Ouahchi, Y., Cheikhrouhou, S., Toujeni, S., Merai, S., Ammous, A., Dhahri, B., Mjid, M. Tags: 02.01 - Acute critical care Source Type: research

Establishing minimally important differences for cardiac MRI end-points in pulmonary arterial hypertension
Conclusions This study establishes clinically relevant CMR MIDs for how a patient "feels, functions or survives" in response to PAH treatment. These findings provide further support for the use of CMR as a clinically relevant clinical outcome measure and will aid trial size calculations for studies using CMR.
Source: European Respiratory Journal - August 3, 2023 Category: Respiratory Medicine Authors: Alabed, S., Garg, P., Alandejani, F., Dwivedi, K., Maiter, A., Karunasaagarar, K., Rajaram, S., Hill, C., Thomas, S., Gossling, R., Sharkey, M. J., Salehi, M., Wild, J. M., Watson, L., Hameed, A., Charalampopoulos, A., Lu, H., Rothman, A. M. K., Thompson, Tags: Pulmonary vascular disease Original Articles: Pulmonary vascular disease Source Type: research

Effects of sotatercept on haemodynamics and right heart function: analysis of the STELLAR trial
Conclusion In pre-treated patients with PAH, sotatercept demonstrated substantial improvements in PA pressures, PA compliance, PA–RV coupling and right heart function.
Source: European Respiratory Journal - September 21, 2023 Category: Respiratory Medicine Authors: Souza, R., Badesch, D. B., Ghofrani, H. A., Gibbs, J. S. R., Gomberg-Maitland, M., McLaughlin, V. V., Preston, I. R., Waxman, A. B., Grünig, E., Kopec, G., Meyer, G., Olsson, K. M., Rosenkranz, S., Lin, J., Johnson-Levonas, A. O., de Oliveira Pena Tags: Original Articles: Pulmonary vascular disease Source Type: research

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