• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Left ventricular strain and dyssynchrony by CMR Feature tracking in Idiopathic Pulmonary Arterial Hypertension(IPAH)
Conclusion: Impaired LV longitudinal strain and intraventricular dyssynchrony appear in IPAH. In the setting of impaired longitudinal function, LVEF is maintained by circumferential contraction. In IPAH with impaired LVEF, circumferential strain is impaired in addition to longitudinal strain.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Jayasekera, G., Mangion, K., Crowe, T., Mackenzie, A., McComb, C., Johnson, M., Church, C., Berry, C., Radjenovic, A., Peacock, A. Tags: Pulmonary Circulation and Pulmonary Vascular Disease Source Type: research

Long-term outcomes of percutaneous coronary intervention in patients with chronic obstructive pulmonary disease: a 13-year nationwide cohort study
Chronic obstructive pulmonary disease (COPD) is associated with increased risk of coronary atherosclerosis. However, its impact on the long-term outcomes in patients undergoing percutaneous coronary intervention (PCI) has not been described. Using the National Health Insurance Research Database of Taiwan, we identified 215275 adult patients who underwent first-time PCI between 2000 and 2012. Among them, the outcomes of patients with COPD (n = 24900) and without COPD (n = 190375) were compared. Baseline demographics and 13-year overall mortality and adverse cardiac outcomes after PCI (i.e., ischemic events, repeat revascula...
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Lin, W.-C., Chen, C.-W., Lai, C.-H. Tags: Epidemiology Source Type: research

Effect of riociguat on pulmonary arterial compliance in patients with pulmonary arterial hypertension (PAH) in the RESPITE study
Conclusion: In RESPITE, riociguat improved PAC in patients with PAH who had transitioned from PDE5i. The increase in PAC was more pronounced in patients whose exercise and functional capacity had also improved by Week 24.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Hoeper, M. M., Corris, P. A., Ghofrani, H.-A., Klinger, J. R., Langleben, D., Naeije, R., Simonneau, G., Jansa, P., Rosenkranz, S., Grünig, E., Scelsi, L., Meier, C., Busse, D., Benza, R. L. Tags: Pulmonary Circulation and Pulmonary Vascular Disease Source Type: research

Obstructive Sleep Apnoea (OSA): Men vs Women
Conclusion: Women had higher BMIs, ESS and lower AHIs than men. M: F ratio with AHI>15 was 2.54 which shows that fewer women than expected are being referred. Our M: F ratio of 2.10 in over 50’s reflects the known higher incidence of OSA in post-menopausal women, but remains below that expected from population studies. Thus more awareness is needed locally to improve recognition of OSA in our female population.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Haqqee, R., Jordan, T., Allen, M. Tags: Sleep and Control of Breathing Source Type: research

Altered synchrony of right ventricular contraction inborderline pulmonary hypertension
Conclusion: RV dyssynchrony occurs in borderline PH and may reflect early RV arterial uncoupling.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Lamia, B., Muir, J.-F., Molano, L.-C., Viacroze, C., Bonnet, P., Quieffin, J., Benichou, J., Cuvelier, A., Naeije, R. Tags: Pulmonary Circulation and Pulmonary Vascular Disease Source Type: research

Validation of cardiac MR parameters in the assessment of pulmonary hemodynamics
Conclusions: In our prospective cohort, the literature-based formulas for calculation of PAP and PVR based on CMR-based measures could largely be validated. The best correlations were derived from multiparametric formulas including right ventricular ejection fraction.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Odler, B., Reiter, U., Reiter, G., Fuchsjäger, M., Foris, V., Tornyos, A., Douschan, P., Pfeiffer, S., Olschewski, A., Olschewski, H., Kovacs, G. Tags: Pulmonary Circulation and Pulmonary Vascular Disease Source Type: research

Chronic bronchitis, asthma and rhinitis are differently associated with cardiovascular risk factors and diseases
Conclusions: our preliminary results suggest that 1) chronic respiratory diseases are associated with different cardiovascular risk factors; 2) the associations of CB and rhinitis with cardiovascular diseases seem to be independent of the presence of shared risk factors.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Pesce, G., Marcon, A., Cazzoletti, L., Battaglia, S., Cerveri, I., Pirina, P., Trucco, G., Locatelli, F., Ferrari, M. Tags: Epidemiology Source Type: research

The effect of 6-mercaptopurine treatment on experimentally induced pulmonary arterial hypertension
Conclusion: 6-MP partly reversed RV systolic pressure and RV afterload in established PAH. Together with the observed improved RV remodeling and cardiac function, 6-MP may be a promising intervention for PAH.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Sun, X.-Q., Kurakula, K., Happe, C., da Silva Goncalves Bos, D., Schalij, I., Vonk-Noordegraaf, A., de Man, F. S., Bogaard, H.-J., Goumans, M.-J. Tags: Pulmonary Circulation and Pulmonary Vascular Disease Source Type: research

Cardiovascular events and mortality in CPAP adherent OSAS patients - a 9-year retrospective study
Conclusions: High adherence to CPAP treatment protected OSAS patients against primary and secondary ischemic cardiovascular events and deaths.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Myllylä, M., Hammais, A., Stepanov, M., Anttalainen, U., Saaresranta, T., Laitinen, T. Tags: Sleep and Control of Breathing Source Type: research

Con: continuous positive airway pressure and cardiovascular prevention
For the last two decades, evidence has been mounting that obstructive sleep apnoea (OSA) may be a cause of cardiovascular disease (CVD). OSA causes repeated acute falls in nocturnal arterial blood oxygen saturation, and rises in blood pressure and heart rate. These physiological changes, combined with the acute mechanical stress placed on the heart from the often very large negative pleural pressure swings during obstructed breathing, were postulated to provide the substrate necessary to induce acute events such as myocardial infarction, arrhythmias, acute heart failure, stroke and sudden cardiovascular death. Observationa...
Source: European Respiratory Journal - May 10, 2018 Category: Respiratory Medicine Authors: McEvoy, R. D., Kohler, M. Tags: Editorials Source Type: research

Obstructive sleep apnoea and exercise functional capacity: time to move?
Obstructive sleep apnoea (OSA) is defined by repetitive episodes of obstructive respiratory events, characterised by marked reduction (hypopnoea) or cessation of respiration (apnoea) due to upper airway obstruction during sleep. Each respiratory event leads to episodes of asphyxia and progressive but futile generation of excessive negative intrathoracic pressure. The patient is typically self-rescued by an arousal from sleep that leads to opening of the airway and resumption of breathing [1]. OSA is common in the general population across the whole human life span from infants to the elderly [2]. There is good evidence bui...
Source: European Respiratory Journal - June 28, 2018 Category: Respiratory Medicine Authors: Farre, N., Lorenzi-Filho, G. Tags: Editorials Source Type: research

Haemodynamics and serial risk assessment in systemic sclerosis associated pulmonary arterial hypertension
The prognostic importance of follow-up haemodynamics and the validity of multidimensional risk assessment are not well established for systemic sclerosis (SSc)-associated pulmonary arterial hypertension (PAH). We assessed incident SSc-PAH patients to determine the association between clinical and haemodynamic variables at baseline and first follow-up right heart catheterisation (RHC) with transplant-free survival. RHC variables included cardiac index, stroke volume index (SVI), pulmonary arterial compliance and pulmonary vascular resistance. Risk assessment was performed according to the number of low-risk criteria: functi...
Source: European Respiratory Journal - October 18, 2018 Category: Respiratory Medicine Authors: Weatherald, J., Boucly, A., Launay, D., Cottin, V., Prevot, G., Bourlier, D., Dauphin, C., Chaouat, A., Savale, L., Jaïs, X., Jevnikar, M., Traclet, J., De Groote, P., Simonneau, G., Hachulla, E., Mouthon, L., Montani, D., Humbert, M., Sitbon, O. Tags: Original Articles: Pulmonary hypertension Source Type: research

Non-aponea sleep disorder increases the risk of incident heart failure - a nationwide population-based cohort study
Conclusions: Our study demonstrates that NASD patients are at a higher risk of incident heart failure.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Wang, I.-D., Peng, C.-K. Tags: Sleep and control of breathing Source Type: research

Lower than expected pulsatile pulmonary arterial load in a thromboembolic pulmonary hypertension model
Conclusions: To our knowledge, this is the first documentation of a PH state where the mPAP-corrected indices of pulsatile arterial load (sPAP, PAPp) were lower than expected. The young age of the animals, the short-term nature of our analysis, or some specific features of the thromboembolic PH model may be involved.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Boulate, D., Chemla, D., Loisel, F., Coblence, M., Provost, B., Decante, B., Herve, P., Fadel, E., Mercier, O. Tags: Pulmonary hypertension Source Type: research

Reappraising the effects of pulmonary artery wedge pressure on right ventricular pulsatile loading
Conclusion: Unexpectedly, PAWP decreased RV pulsatile loading (as reflected in PA stiffness) when potential confounding factors, including the prevailing mPAP, were taken into account. Our results deserve further independent confirmation.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Chemla, D., Berthelot, E., Weatherald, J., Savale, L., Attal, P., Montani, D., Sitbon, O., Humbert, M., Herve, P., Assayag, P. Tags: Pulmonary hypertension Source Type: research

Pages: 1  2  3  4  5  6  7  8