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Source: Atherosclerosis
Condition: Heart Failure
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Total 212 results found since Jan 2013.
COVID-19-induced cardiovascular damage differs from other prevalent viruses
Cardiol Plus. 2021 Oct 1;6(4):231-245. doi: 10.4103/2470-7511.334401. Epub 2021 Dec 30.ABSTRACTViral infections persist globally, among all ages, gender, and ethnicity. Of particular importance is COVID-19, associated with asymptomatic to severe symptoms, including complications/mortality. Cardiovascular disease (CVD) involves heart and blood vessel disorders including coronary heart disease, cerebrovascular disease, peripheral artery disease, thrombosis, and more. CVD associated with severe COVID-19 includes heart failure, coronary artery disease, cardiomyopathy, hypertension, and cerebrovascular disease/stroke. Data were...
Source: Atherosclerosis - April 4, 2022 Category: Cardiology Authors: Rachel S Parise Sindhu Ramesh Manoj Govindarajulu Amir Ajoolabady Timothy Moore Muralikrishnan Dhanasekaran Source Type: research
Elevated Lipoprotein(a) and Risk of Atrial Fibrillation: An Observational and Mendelian Randomization Study
CONCLUSIONS: Our findings implicate Lp(a) as a potential causal mediator in the development of AF which show that the effects of Lp(a) extend across myocardial tissues. Ongoing clinical trials for Lp(a)-lowering therapies should evaluate effects on AF prevention.PMID:35450575 | DOI:10.1016/j.jacc.2022.02.018
Source: Atherosclerosis - April 22, 2022 Category: Cardiology Authors: Pedrum Mohammadi-Shemirani Michael Chong Sukrit Narula Nicolas Perrot David Conen Jason D Roberts S ébastien Thériault Yohan Boss é Matthew B Lanktree Marie Pigeyre Guillaume Par é Source Type: research
Cannabinoid receptor 2 activation alleviates diabetes-induced cardiac dysfunction, inflammation, oxidative stress, and fibrosis
In this study, we explored the role of CB2R signaling in myocardial dysfunction, oxidative/nitrative stress, inflammation, cell death, remodeling, and fibrosis associated with diabetic cardiomyopathy in type 1 diabetic mice. Control human heart left ventricles and atrial appendages, similarly to mouse hearts, had negligible CB2R expression determine by RNA sequencing or real-time RT-PCR. Diabetic cardiomyopathy was characterized by impaired diastolic and systolic cardiac function, enhanced myocardial CB2R expression, oxidative/nitrative stress, and pro-inflammatory response (tumor necrosis factor-α, interleukin-1β, intra...
Source: Atherosclerosis - April 23, 2022 Category: Cardiology Authors: Mohanraj Rajesh Partha Mukhopadhyay S ándor Bátkai Muhammad Arif Zolt án V Varga Csaba M átyás Janos Paloczi Andrea Lehocki Gy örgy Haskó Pal Pacher Source Type: research
Assessment of Visit-to-Visit Blood Pressure Variability in Adults With Optimal Blood Pressure: A New Player in the Evaluation of Residual Cardiovascular Risk?
Conclusions In adults with optimal SBP levels, higher visit-to-visit SBP variability was significantly associated with a higher risk of MACE regardless of whether they had hypertension. Therefore, it may be necessary to further focus on the visit-to-visit SBP variability even at the guideline-recommended optimal blood pressure levels.PMID:35470678 | DOI:10.1161/JAHA.121.022716
Source: Atherosclerosis - April 26, 2022 Category: Cardiology Authors: Menghui Liu Xiaohong Chen Shaozhao Zhang Junfan Lin Lichun Wang Xinxue Liao Xiaodong Zhuang Source Type: research
Links between chronic exposure to outdoor air pollution and cardiovascular diseases: a review
Environ Chem Lett. 2022 Apr 25:1-18. doi: 10.1007/s10311-022-01450-9. Online ahead of print.ABSTRACTAcute exposure to air pollution is associated with an increasing risk of death and cardiovascular disorders. Nonetheless, the impact of chronic exposure to air pollution on the circulatory system is still debated. Here, we review the links of chronic exposure to outdoor air pollution with mortality and most common cardiovascular diseases, in particular during the coronavirus disease 2019 event (COVID-19). We found that recent studies provide robust evidence for a causal effect of chronic exposure to air pollution and cardiov...
Source: Atherosclerosis - May 2, 2022 Category: Cardiology Authors: Ewa Konduracka Pawe ł Rostoff Source Type: research
Low serum albumin: A neglected predictor in patients with cardiovascular disease
Eur J Intern Med. 2022 May 7:S0953-6205(22)00181-9. doi: 10.1016/j.ejim.2022.05.004. Online ahead of print.ABSTRACTAlbumin, the most abundant circulating protein in blood, is an essential protein which binds and transports various drugs and substances, maintains the oncotic pressure of blood and influences the physiological function of the circulatory system. Albumin also has anti-inflammatory, antioxidant, and antithrombotic properties. Evidence supports albumin's role as a strong predictor of cardiovascular (CV) risk in several patient groups. Its protective role extends to those with coronary artery disease, heart failu...
Source: Atherosclerosis - May 10, 2022 Category: Cardiology Authors: Antonis A Manolis Theodora A Manolis Helen Melita Dimitri P Mikhailidis Antonis S Manolis Source Type: research
Effect of a low dose of empagliflozin on short-term outcomes in type 2 diabetics with acute coronary syndrome after percutaneous coronary intervention
CONCLUSION: The results of this study showed that adding low dose empagliflozin to standard care of ACS diabetic patients after PCI was associated with no significant reduction in negative cardiovascular outcomes during 6 months.PMID:35537720 | DOI:10.15537/smj.2022.43.5.20220018
Source: Atherosclerosis - May 10, 2022 Category: Cardiology Authors: Seyed Mohammad H Adel Fateme Jorfi Hoda Mombeini Homeira Rashidi Saad Fazeli Source Type: research
Evolutionary cardiology and experimental research
Arch Cardiol Mex. 2022 May 10. doi: 10.24875/ACM.210002751. Online ahead of print.ABSTRACTEvolutionary medicine studies the role of evolution in health problems. Diseases are considered as phenotypes generated by the expression of sets of genes and a complex interplay with the environment. The main mechanisms involved in evolutionary medicine are antagonistic pleiotropy, ecological antagonistic pleiotropy, atavisms and heterochrony. Antagonistic pleiotropism refers to genes that are beneficial during certain stages of development but become detrimental in others. Ecological antagonistic pleiotropy refers to the misadaptati...
Source: Atherosclerosis - May 10, 2022 Category: Cardiology Authors: Agustina Cano-Mart ínez Ma Esther Rubio-Ruiz Ver ónica Guarner-Lans Source Type: research
The enigmatic role of VCAM-1 expressed by macrophages in mitochondrial metabolism and atherosclerosis
CONCLUSION: We conclude that macrophage-specific VCAM-1 augments mitochondrial biogenesis and DNA oxidation via Cmpk2. Oxidized mitochondrial DNA in plaque macrophages increases inflammation via Sting, resulting in exacerbation of atherosclerosis.PMID:35557156 | DOI:10.1096/fasebj.2022.36.S1.R6141
Source: Atherosclerosis - May 13, 2022 Category: Cardiology Authors: Niranjana Natarajan Jonathan Florentin Scott P O'Neil Lee L Ohayon Partha Dutta Source Type: research
Midlife determinants of healthy cardiovascular aging: The Atherosclerosis Risk in Communities (ARIC) study
CONCLUSIONS: More-stringent levels of modifiable risk factors in midlife beyond current clinical practice and guidelines were associated with preserved cardiovascular health in older age.PMID:35550933 | DOI:10.1016/j.atherosclerosis.2022.04.028
Source: Atherosclerosis - May 13, 2022 Category: Cardiology Authors: Xiaoming Jia Caroline Sun Vijay Nambi Salim S Virani George Taffet Eric Boerwinkle Jan Bressler Chiadi Ndumele B Gwen Windham James A de Lemos Kunihiro Matsushita John William McEvoy Ron C Hoogeveen Elizabeth Selvin Christie M Ballantyne Source Type: research
N6-Methyladenosine RNA Methylation in Cardiovascular Diseases
Front Cardiovasc Med. 2022 Apr 29;9:887838. doi: 10.3389/fcvm.2022.887838. eCollection 2022.ABSTRACTN6-methyladenosine (m6A) modification is the most universal and abundant post-transcriptional modification of eukaryotic RNA and occurs mainly at the consensus motif RR (m6A) CH (R = A or G, H = A, C, or U) in long internal exons, near stop codons, or in the 3' untranslated region (UTR). "Writers," "erasers," and "readers" are responsible for the occurrence, removal, and recognition of m6A modification, respectively. Substantial evidence has shown that m6A RNA modification can exert important functions in physiological and p...
Source: Atherosclerosis - May 16, 2022 Category: Cardiology Authors: Chi Liu Lei Gu Wenjuan Deng Qianchao Meng Nan Li Guifeng Dai Suli Yu Hong Fang Source Type: research
