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Source: Atherosclerosis
Condition: Heart Failure
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Total 212 results found since Jan 2013.
Laboratory Grown Biofilms of Bacteria Associated with Human Atherosclerotic Carotid Arteries Release Collagenases and Gelatinases during Iron-Induced Dispersion
This study shows that plaque-associated bacteria, when cultured as mixed-species biofilms in the laboratory, can release degradative enzymes into their environment as the result of a dispersion response triggered by iron. These degradative enzymes can digest proteins and lipids which are associated with the tissues that separate the plaque lesion from the arterial lumen. Thus, this study demonstrates that if mixed species biofilms are induced to undergo dispersion in an infected atherosclerotic lesion when exposed to an elevated concentration of free iron, they have the potential to contribute to the weakening of arterial ...
Source: Atherosclerosis - May 11, 2022 Category: Cardiology Authors: Amanda M Zdimal David G Davies Source Type: research
Circulating Magnesium and Risk of Major Adverse Cardiac Events among Patients with Atrial Fibrillation in the ARIC Cohort
Conclusions: Among patients with AF, higher serum Mg was associated with a lower risk of developing incident MI and, to a lesser extent, other CV endpoints. Further studies in larger patients with AF cohorts are needed to evaluate the role of serum Mg in preventing adverse CV outcomes in these patients.PMID:36904210 | DOI:10.3390/nu15051211
Source: Atherosclerosis - March 11, 2023 Category: Cardiology Authors: Linzi Li Pamela L Lutsey Lin Yee Chen Elsayed Z Soliman Mary R Rooney Alvaro Alonso Source Type: research
A causal relationship between irritability and cardiovascular diseases: a Mendelian randomization study
CONCLUSION: Our findings support the first genetic evidence of the causality of genetically predicted irritability with the risk of developing into CVDs. Our results deliver a viewpoint that more early active interventions to manage an individual's anger and related unhealthy lifestyle habits are needed to prevent the occurrence of adverse cardiovascular events.PMID:37324625 | PMC:PMC10267866 | DOI:10.3389/fcvm.2023.1174329
Source: Atherosclerosis - June 16, 2023 Category: Cardiology Authors: Dihui Cai Yin Fu Yongfei Song Hui Lin Yanna Ba Jiangfang Lian Source Type: research
Association between CRP/Albumin ratio and long-term mortality in patients with cHronIc Limb-threatening ischemia undergoing EndovaScular therapy Below The Knee: The ACHILES-BTK Registry
CONCLUSIONS: CAR was associated with mortality in CLTI patients undergoing EVT for BTK lesions. CAR may be a simple method to help patient selection, assessment, and intervention strategy for EVT and may improve patient outcomes.PMID:34896550 | DOI:10.1016/j.avsg.2021.11.008
Source: Atherosclerosis - December 13, 2021 Category: Cardiology Authors: Cafer Pan ç Arda G üler İsmail Gürbak Ömer Taşbulak Ahmet G üner Ali Kemal Kalkan Ahmet Arif Yal çın Mehmet Ert ürk Source Type: research
Sphingosine 1-phosphate and its regulatory role in vascular endothelial cells
We presently review the levels of S1P in those vascular and vascular-related diseases. Plasma S1P levels were reduced in various inflammation-related diseases such as atherosclerosis and sepsis, but were increased in other diseases including type 2 diabetes, neurodegeneration, cerebrovascular damages such as acute ischemic stroke, Alzheimer's disease, vascular dementia, angina, heart failure, idiopathic pulmonary fibrosis, community-acquired pneumonia, and hepatocellular carcinoma. Then, we highlighted the molecular mechanism by which S1P regulated EC biology including vascular development and angiogenesis, inflammation, p...
Source: Atherosclerosis - February 4, 2022 Category: Cardiology Authors: Yan Qiu Junyi Shen Wenli Jiang Yi Yang Xiaoheng Liu Ye Zeng Source Type: research
Exploring blood microbial communities and their influence on human cardiovascular disease
CONCLUSION: Proteobacteria and Actinobacteria were shown to be independent markers of the risk of CVD. This finding is evidence for the new concept of the role played by blood microbiota dysbiosis in CVD. However, the association between blood microbiota and CVD is still inconsistent. Thus, more deep investigations are required in future to fully understand the role of the bacteria community in causing and preventing CVD.PMID:35293034 | DOI:10.1002/jcla.24354
Source: Atherosclerosis - March 16, 2022 Category: Cardiology Authors: Ikram Khan Imran Khan Zhou Jianye Zhang Xiaohua Murad Khan Mian Gul Hilal Mian Adnan Kakakhel Arshad Mehmood An Lizhe Li Zhiqiang Source Type: research
Aldosterone and cardiovascular diseases
Cardiovasc Res. 2022 Apr 7:cvac027. doi: 10.1093/cvr/cvac027. Online ahead of print.ABSTRACTAldosterone's role in the kidney and its pathophysiologic actions in hypertension are well known. However, its role or that of its receptor [minieralocorticoid receptor (MR)] in other cardiovascular (CV) disease are less well described. To identify their potential roles in six CV conditions (heart failure, myocardial infarction, atrial fibrillation, stroke, atherosclerosis, and thrombosis), we assessed these associations in four areas: 1) mechanistic studies in rodents and humans; 2) preclinical studies of MR antagonists; 3) clinica...
Source: Atherosclerosis - April 7, 2022 Category: Cardiology Authors: Wasita W Parksook Gordon H Williams Source Type: research
Causal Association of Type 2 Diabetes Mellitus and Glycemic Traits With Cardiovascular Diseases and Lipid Traits: A Mendelian Randomization Study
CONCLUSION: We provided evidence for the causal effects of T2DM and glycemic traits on the risk of CVDs and dyslipidemia. Further investigations to elucidate the underlying mechanisms are warranted.PMID:35528012 | PMC:PMC9072667 | DOI:10.3389/fendo.2022.840579
Source: Atherosclerosis - May 9, 2022 Category: Cardiology Authors: Mingkai Huang Loum-Davadi Laina-Nicaise Lingfeng Zha Tingting Tang Xiang Cheng Source Type: research
Cardiovascular Disease Risk Among Cancer Survivors: The Atherosclerosis Risk In Communities (ARIC) Study
CONCLUSIONS: Compared with persons without cancer, adult cancer survivors have significantly higher risk of CVD, especially HF, independent of traditional cardiovascular risk factors. There is an unmet need to define strategies for CVD prevention in this high-risk population.PMID:35772913 | DOI:10.1016/j.jacc.2022.04.042
Source: Atherosclerosis - June 30, 2022 Category: Cardiology Authors: Roberta Florido Natalie R Daya Chiadi E Ndumele Silvia Koton Stuart D Russell Anna Prizment Roger S Blumenthal Kunihiro Matsushita Yejin Mok Ashley S Felix Josef Coresh Corinne E Joshu Elizabeth A Platz Elizabeth Selvin Source Type: research
