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Condition: Dementia

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The next step in stroke prevention: addressing both blood clotting and protection of the blood vessels
As growing numbers of America's baby boomers reach retirement, neuroscientists are expanding their efforts to understand and treat one of the leading health issues affecting this population: age-related neurological deterioration, including stroke and dementia. One factor coming under increased study is cerebral microbleeds, experienced by nearly 20 percent of people by age 60 and nearly 40 percent by age 80...
Source: Health News from Medical News Today - November 4, 2013 Category: Consumer Health News Tags: Stroke Source Type: news

Atrial fibrillation is associated with an increased risk of cognitive impairment and dementia with or without a history of clinical stroke
Commentary on: Kalantarian S, Stern TA, Mansour M, et al.. Cognitive impairment associated with atrial fibrillation: a meta-analysis. Ann Intern Med 2013;158(5 Pt 1):338–46. Context Atrial fibrillation (AF) is the most common cardiac arrhythmia in clinical practice. The estimated US prevalence of 2.7–6.1 million is expected to increase to 5.6–12.1 million by the middle of the current century. In addition, AF prevalence dramatically increases with age: <1% in individuals aged 50–59 years are affected, whereas about 10% of those aged 80–84 years and 11–18% of those ≥85 ...
Source: Evidence-Based Medicine - January 22, 2014 Category: Internal Medicine Authors: Forti, P. Tags: EBM Aetiology, Epidemiologic studies, Drugs: cardiovascular system, Dementia, Drugs: CNS (not psychiatric), Stroke, Memory disorders (psychiatry), Psychiatry of old age, Arrhythmias Source Type: research

Cortical Microinfarcts Detected In Vivo on 3 Tesla MRI: Clinical and Radiological Correlates Brief Reports
Conclusions— We found an association of CMIs with clinical parameters, including age and cardiovascular risk factors. Although the prevalence of CMIs is relatively low, our results suggest that the study of CMIs in larger clinical studies is possible using 3 Tesla MRI. This opens the possibility of large-scale prospective investigation of the clinical relevance of CMIs in older people.
Source: Stroke - December 22, 2014 Category: Neurology Authors: van Dalen, J. W., Scuric, E. E. M., van Veluw, S. J., Caan, M. W. A., Nederveen, A. J., Biessels, G. J., van Gool, W. A., Richard, E. Tags: Acute Cerebral Infarction, Cerebral Lacunes, Risk Factors for Stroke Brief Reports Source Type: research

Cysteine-Sparing CADASIL Mutations in NOTCH3 Show Proaggregatory Properties In Vitro Clinical Sciences
Conclusions— Our findings support the view that cysteine-sparing mutations, such as D80G, might cause CADASIL with a phenotype largely indistinguishable from cysteine mutations. The in vitro aggregation analysis of atypical NOTCH3 mutations offers novel insights into pathomechanisms and might represent a tool for estimating their clinical significance.
Source: Stroke - February 23, 2015 Category: Neurology Authors: Wollenweber, F. A., Hanecker, P., Bayer-Karpinska, A., Malik, R., Bazner, H., Moreton, F., Muir, K. W., Muller, S., Giese, A., Opherk, C., Dichgans, M., Haffner, C., Duering, M. Tags: Clinical genetics, Cerebrovascular disease/stroke, Other diagnostic testing, Other Vascular biology Clinical Sciences Source Type: research

Selective astrocytic endothelin-1 overexpression contributes to dementia associated with ischemic stroke by exaggerating astrocyte-derived amyloid secretion
g & Sookja K Chung
Source: Journal of Cerebral Blood Flow - June 24, 2015 Category: Neurology Authors: Victor K L HungPatrick K K YeungAngela K W LaiMaggie C Y HoAmy C Y LoKevin C ChanEd X K WuStephen S M ChungChi W CheungSookja K Chung Tags: Alzheimer’s disease amyloidosis astrocytes endothelin-1 ischemic stroke Source Type: research

Prevalence and Risk Factors of Acute Incidental Infarcts Clinical Sciences
Conclusions— AII are more likely to be present in those with cognitive impairment. Although a cause–effect relationship between the presence of AII and cognitive impairment is plausible, the association may be because of under-reporting of symptoms by individuals with cognitive impairment. The association between AII and cerebral microbleeds may indicate cerebral vasculopathy, independent of traditional vascular risk factors.
Source: Stroke - September 28, 2015 Category: Neurology Authors: Saini, M., Suministrado, M. S. P., Hilal, S., Dong, Y. H., Venketasubramanian, N., Ikram, M. K., Chen, C. Tags: Acute Stroke Syndromes Clinical Sciences Source Type: research

Association of Magnetic Resonance Imaging Markers of Cerebrovascular Disease Burden and Cognition Clinical Sciences
Conclusions— The weighted CeVD burden score comprising markers of both small- and large-vessel diseases were associated with deficits in both global and domain-specific neurocognitive function. Additional studies are needed to validate the use of this CeVD burden score for the prediction of dementia.
Source: Stroke - September 28, 2015 Category: Neurology Authors: Xu, X., Hilal, S., Collinson, S. L., Chong, E. J. Y., Ikram, M. K., Venketasubramanian, N., Chen, C. L.-H. Tags: Cerebrovascular disease/stroke, CT and MRI Clinical Sciences Source Type: research

Selective astrocytic endothelin-1 overexpression contributes to dementia associated with ischemic stroke by exaggerating astrocyte-derived amyloid secretion
g & Sookja K Chung
Source: Journal of Cerebral Blood Flow and Metabolism - September 30, 2015 Category: Neuroscience Authors: Victor K L HungPatrick K K YeungAngela K W LaiMaggie C Y HoAmy C Y LoKevin C ChanEd X K WuStephen S M ChungChi W CheungSookja K Chung Tags: Alzheimer’s disease amyloidosis astrocytes endothelin-1 ischemic stroke Source Type: research

Dementia after Three Months and One Year from Stroke: New Onset or Previous Cognitive Impairment?
Stroke is an important risk factor for dementia, but the exact mechanism involved in cognitive decline remains unclear.
Source: Journal of Stroke and Cerebrovascular Diseases - August 7, 2016 Category: Neurology Authors: Salvatore Caratozzolo, Giulia Mombelli, Maddalena Riva, Marina Zanetti, Federica Gottardi, Alessandro Padovani, Luca Rozzini Source Type: research

Prevalence and Risk Factors for Delirium in Acute Stroke Patients. A Retrospective 5-Years Clinical Series
This study aims to evaluate the prevalence of delirium and to identify risk factors.
Source: Journal of Stroke and Cerebrovascular Diseases - December 21, 2016 Category: Neurology Authors: Francisco Jos é Alvarez-Perez, Fatima Paiva Source Type: research

Sugar-Sweetened and Artificially Sweetened Beverages in Relation to Stroke and Dementia Editorial
Source: Stroke - April 24, 2017 Category: Neurology Authors: Heike Wersching, Hannah Gardener, Ralph L. Sacco Tags: Diet and Nutrition, Epidemiology, Cognitive Impairment, Ischemic Stroke Editorials Source Type: research

Diet Sodas Tied to Dementia and Stroke
People who drank one to six artificially sweetened drinks a week had a higher risk of stroke or dementia.
Source: NYT Health - April 26, 2017 Category: Consumer Health News Authors: NICHOLAS BAKALAR Tags: Stroke Dementia Soft Drinks Source Type: news

Letter by Chiu Regarding Article, “Sugar- and Artificially Sweetened Beverages and the Risks of Incident Stroke and Dementia. A Prospective Cohort Study” Letter to the Editor
Source: Stroke - July 24, 2017 Category: Neurology Authors: Edward K. Chiu Tags: Diet and Nutrition, Ischemic Stroke Letters to the Editor Source Type: research

Response by Pase et al to Letters Regarding Article, “Sugar- and Artificially Sweetened Beverages and the Risks of Incident Stroke and Dementia. A Prospective Cohort Study” Letter to the Editor
Source: Stroke - July 24, 2017 Category: Neurology Authors: Matthew P. Pase, Jayandra J. Himali, Alexa Beiser, Sudha Seshadri, Paul F. Jacques Tags: Epidemiology, Risk Factors, Cerebrovascular Disease/Stroke Letters to the Editor Source Type: research

Response by Pase et al to Letter Regarding Article, “Sweetened Beverages and the Risks of Incident Stroke and Dementia” Letter to the Editor
Source: Stroke - August 28, 2017 Category: Neurology Authors: Matthew P. Pase, Jayandra J. Himali, Sudha Seshadri, Paul F. Jacques Tags: Diet and Nutrition, Epidemiology, Risk Factors, Ischemic Stroke Letters to the Editor Source Type: research