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Condition: Dementia

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Total 4555 results found since Jan 2013.

Long-Term Exposure to Fine Particulate Matter, Residential Proximity to Major Roads and Measures of Brain Structure Clinical Sciences
Conclusions— Exposure to elevated levels of PM2.5 was associated with smaller total cerebral brain volume, a marker of age-associated brain atrophy, and with higher odds of covert brain infarcts. These findings suggest that air pollution is associated with insidious effects on structural brain aging even in dementia- and stroke-free persons.
Source: Stroke - April 27, 2015 Category: Neurology Authors: Wilker, E. H., Preis, S. R., Beiser, A. S., Wolf, P. A., Au, R., Kloog, I., Li, W., Schwartz, J., Koutrakis, P., DeCarli, C., Seshadri, S., Mittleman, M. A. Tags: Computerized tomography and Magnetic Resonance Imaging, Risk Factors for Stroke, Epidemiology Clinical Sciences Source Type: research

Cognitive Decline in Patients with Leukoaraiosis Within 5 Years after Initial Stroke
In this study, we sought to identify whether LA contributes to the occurrence of certain type of cognitive disorders after initial stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - July 31, 2015 Category: Neurology Authors: Emre Kumral, Halil Güllüoğlu, Naila Alakbarova, Emrah E. Deveci, Ayşe Y. Çolak, Ayşe D. Çağında, Dilek Evyapan, Mehmet Orman Source Type: research

Cognitive performance and poor long-term functional outcome after young stroke
Conclusions: On average, 11 years after young IS there was no clear relationship between long-term cognitive deficits and long-term functional outcome or IADL, stressing the need for further prospective studies with further development of sensitive measures of functional prognosis.
Source: Neurology - August 31, 2015 Category: Neurology Authors: Synhaeve, N. E., Schaapsmeerders, P., Arntz, R. M., Maaijwee, N. A. M., Rutten-Jacobs, L. C. A., Schoonderwaldt, H. C., Dorresteijn, L. D. A., de Kort, P. L. M., van Dijk, E. J., Kessels, R. P. C., de Leeuw, F.-E. Tags: Stroke in young adults, Prognosis, Assessment of cognitive disorders/dementia ARTICLE Source Type: research

Predictors of Clinical Worsening in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy: Prospective Cohort Study Clinical Sciences
Conclusions— Clinical assessment and brain magnetic resonance imaging aid in predicting incident clinical events and clinical deterioration in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. There is a bidirectional relationship between dementia and moderate or severe disability in predicting each other’s onset. Active smoking is a modifiable risk factor associated with clinical progression in Notch3 mutation carriers.
Source: Stroke - December 28, 2015 Category: Neurology Authors: Chabriat, H., Herve, D., Duering, M., Godin, O., Jouvent, E., Opherk, C., Alili, N., Reyes, S., Jabouley, A., Zieren, N., Guichard, J.-P., Pachai, C., Vicaut, E., Dichgans, M. Tags: Risk Factors, Genetics, Cerebrovascular Disease/Stroke, Cognitive Impairment, Vascular Disease Clinical Sciences Source Type: research

Test Accuracy of Informant-Based Cognitive Screening Tests for Diagnosis of Dementia and Multidomain Cognitive Impairment in Stroke Clinical Sciences
Conclusions— There is a limited literature on informant cognitive assessments in stroke. IQCODE as a diagnostic tool has test properties similar to other screening tools, IQCODE as a prognostic tool is specific but insensitive. We found no papers describing test accuracy of informant tests for diagnosis of prestroke cognitive decline, few papers on poststroke dementia and all included papers had issues with potential bias.
Source: Stroke - January 25, 2016 Category: Neurology Authors: McGovern, A., Pendlebury, S. T., Mishra, N. K., Fan, Y., Quinn, T. J. Tags: Diagnostic Testing, Behavioral/Psychosocial Treatment, Cognitive Impairment Clinical Sciences Source Type: research

Rate of Endovascular Therapy in Octogenarian/Nonagenarian Acute Ischemic Stroke Patients Compared to Younger Patients (I2.007)
Conclusions: Frequency of EVT and IV-TPA use in AIS patients 蠅80years are increasing but rates remain significantly lower compared with younger patients. Disparity in EVT use in octogenarian/nonagenarian also exists by race and hospital factors. Targeted efforts are needed to lessen this disparity.Disclosure: Dr. Otite has nothing to disclose. Dr. Khandelwal has nothing to disclose. Dr. Tipirneni has nothing to disclose. Dr. Fellman has nothing to disclose. Dr. Malik has nothing to disclose. Dr. Yavagal has received personal compensation for activities with Covidien/evV3 as a consultant and Steering Committee Member...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Otite, F., Khandelwal, P., Tipirneni, A., Fellman, M., Malik, A., Yavagal, D., Chaturvedi, S. Tags: Stroke in the Elderly and Young: Challenges for the Next Decade Data Blitz Presentations Source Type: research

Cerebral Amyloid Angiopathy Is Associated With Executive Dysfunction and Mild Cognitive Impairment Clinical Sciences
Conclusions— Mild cognitive impairment is very prevalent in CAA. The overall cognitive profile of CAA is more similar to that seen in vascular cognitive impairment rather than Alzheimer’s disease. White matter ischemic lesions may underlie some of the impaired processing speed in CAA.
Source: Stroke - July 24, 2016 Category: Neurology Authors: Case, N. F., Charlton, A., Zwiers, A., Batool, S., McCreary, C. R., Hogan, D. B., Ismail, Z., Zerna, C., Coutts, S. B., Frayne, R., Goodyear, B., Haffenden, A., Smith, E. E. Tags: Cerebrovascular Disease/Stroke, Cognitive Impairment, Intracranial Hemorrhage Clinical Sciences Source Type: research

Brief Screening of Vascular Cognitive Impairment in Patients With Cerebral Autosomal-Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy Without Dementia Clinical Sciences
Conclusions— The results indicate that the BMET and the MoCA are clinically useful and sensitive screening measures for early cognitive impairment in patients with CADASIL.
Source: Stroke - September 25, 2016 Category: Neurology Authors: Brookes, R. L., Hollocks, M. J., Tan, R. Y. Y., Morris, R. G., Markus, H. S. Tags: CADASIL, Cerebrovascular Disease/Stroke, Cognitive Impairment Clinical Sciences Source Type: research

Thrombolysis for acute ischemic stroke in patients with leukoaraiosis: Caution needed
The term leukoaraiosis (LA), introduced about 30 years ago,1 describes cerebral white matter signal abnormalities (or white matter hyperintensities) commonly observed on structural brain magnetic resonance or CT imaging in elderly individuals. LA severity can be graded using categorical classification, based on different rating scales,2 or continuously, using automatic quantification algorithms. LA has multiple histopathologic correlates, including ependymal loss, cerebral ischemia, demyelination, venous collagenosis, and microcystic infarcts.3 A substantial body of evidence now supports associations between LA and increas...
Source: Neurology - February 12, 2017 Category: Neurology Authors: Streifler, J., Maillard, P. Tags: All Cerebrovascular disease/Stroke, Clinical trials Systematic review/meta analysis, Infarction, Intracerebral hemorrhage EDITORIALS Source Type: research

Validation of the Telephone Interview of Cognitive Status and Telephone Montreal Cognitive Assessment Against Detailed Cognitive Testing and Clinical Diagnosis of Mild Cognitive Impairment After Stroke Clinical Sciences
Background and Purpose—Assessment of cognitive status poststroke is recommended by guidelines but follow-up can often not be done in person. The Telephone Interview of Cognitive Status (TICS) and the Telephone Montreal Cognitive Assessment (T-MoCA) are considered useful screening instruments. Yet, evidence to define optimal cut-offs for mild cognitive impairment (MCI) after stroke is limited.Methods—We studied 105 patients enrolled in the prospective DEDEMAS study (Determinants of Dementia After Stroke; NCT01334749). Follow-up visits at 6, 12, 36, and 60 months included comprehensive neuropsychological testing and the ...
Source: Stroke - October 23, 2017 Category: Neurology Authors: Vera Zietemann, Anna Kopczak, Claudia Muller, Frank Arne Wollenweber, Martin Dichgans Tags: Clinical Studies, Cognitive Impairment Original Contributions Source Type: research

Pathophysiology and Risk of Atrial Fibrillation Detected after Ischemic Stroke (PARADISE): A Translational, Integrated, and Transdisciplinary Approach
It has been hypothesized that ischemic stroke can cause atrial fibrillation. By elucidating the mechanisms of neurogenically mediated paroxysmal atrial fibrillation, novel therapeutic strategies could be developed to prevent atrial fibrillation occurrence and perpetuation after stroke. This could result in fewer recurrent strokes and deaths, a reduction or delay in dementia onset, and in the lessening of the functional, structural, and metabolic consequences of atrial fibrillation on the heart.
Source: Journal of Stroke and Cerebrovascular Diseases - November 13, 2017 Category: Neurology Authors: Maryse Paquet, Joshua O. Cerasuolo, Victoria Thorburn, Sebastian Fridman, Rasha Alsubaie, Renato D. Lopes, Lauren E. Cipriano, Paula Salamone, C.W. James Melling, Ali R. Khan, Lucas Sede ño, Jiming Fang, Maria Drangova, Manuel Montero-Odasso, Jennifer Ma Source Type: research

A Case of Creutzfeldt-Jakob Disease with Stroke-Like Onset
Creutzfeldt-Jakob disease (CJD) is a prion disease characterized by rapidly progressive dementia that is often followed by behavioral disturbances, ataxia, myoclonus, and akinetic mutism. The initial symptoms of CJD reportedly vary, but the onset is usually gradual. Here, we report a case of CJD with a sudden, stroke-like onset of right hemiparesis to alert readers that CJD can mimic a stroke during its early stage.
Source: Journal of Stroke and Cerebrovascular Diseases - March 27, 2020 Category: Neurology Authors: Kosuke Okamoto, Takato Abe, Yoshiaki Itoh Tags: Case Report Source Type: research

Association Between Small Vessel Disease Markers, Medial Temporal Lobe Atrophy and Cognitive Impairment After Stroke: A Systematic Review and Meta-Analysis
Two-thirds of stroke survivors suffer from cognitive impairment, and up to one-third of them progress to dementia. However, the underlying pathogenesis is complex and controversial. Recent evidence has found that cerebral small vessel disease (SVD) markers and the Alzheimer's disease (AD) neuroimaging marker medial temporal lobe atrophy (MTLA), alone or in combination, contribute to the pathogenesis of poststroke cognitive impairment (PSCI). In the present systematic review and meta-analysis, we synthesized proof for these neuroimaging risk factors among stroke patients.
Source: Journal of Stroke and Cerebrovascular Diseases - November 20, 2020 Category: Neurology Authors: Furu Wang, Sunyu Hua, Yue Zhang, Hongchang Yu, Zhongshuai Zhang, Jiangtao Zhu, Rong Liu, Zhen Jiang Source Type: research

Cerebral Structure and Function in Stroke-free Patients with Atrial Fibrillation
Atrial fibrillation (AF) is associated with high risk of dementia and brain atrophy in stroke-free patients, but the mechanisms underlying this association remain unclear. We aimed to examine the brain volume and connectivity of paramount cognitive brain networks in stroke-free patients with AF without dementia.
Source: Journal of Stroke and Cerebrovascular Diseases - June 5, 2021 Category: Neurology Authors: Danilo S. Silva, Bruna G. Caseli, Brunno M. de Campos, Wagner M. Avelar, Ana Paula B.L. Lino, Marcio L.F. Balthazar, Marcio J.O. Figueiredo, Fernando Cendes, Luiz Fernando L. Pegoraro, Ana Carolina Coan Source Type: research

A Novel Useful Tool of Computerized Touch Panel–Type Screening Test for Evaluating Cognitive Function of Chronic Ischemic Stroke Patients
Cognitive and affective impairments are important non-motor features of ischemic stroke (IS) related to white-matter hyperintensity, including periventricular hyperintensity (PVH). To confirm the usefulness of a novel computerized touch panel–type screening test, we investigated cognitive and affective functioning among 142 IS patients and 105 age-and gender-matched normal control subjects. Assessment using the mini-mental state examination, Hasegawa Dementia Scale-Revised, and frontal assessment battery revealed reduced cognitive function in IS patients, with the most severe reduction exhibited by cardiogenic embolism p...
Source: Journal of Stroke and Cerebrovascular Diseases - January 4, 2013 Category: Neurology Authors: Kentaro Deguchi, Syoichiro Kono, Shoko Deguchi, Nobutoshi Morimoto, Tomoko Kurata, Yoshio Ikeda, Koji Abe Tags: Original Articles Source Type: research