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Total 1184 results found since Jan 2013.

Real-world impact of disease on functioning and activity: what is missed when using general instruments to estimate quality-adjusted life year
CONCLUSION: Differences in rankings of disease severity by metric indicate that the results of cost-utility analyses might be biased against treatments for certain diseases. As patient preferences for clinical outcomes vary, the full burden of disease should be considered in evaluations. Restricting access to treatments based on an incomplete estimate of burden could lead to misallocation of resources and a withholding of therapies that patients find valuable.PMID:34775901 | DOI:10.1080/03007995.2021.2006535
Source: Current Medical Research and Opinion - November 15, 2021 Category: Research Authors: Tingjian Yan Jesse D Ortendahl Eunice Chang Zac Wessler Amanda L Harmon Michael S Broder Source Type: research

Clinical presentation of children with Deficiency of Adenosine deaminase 2: A case series
Eur J Med Genet. 2022 Jun 28;65(8):104555. doi: 10.1016/j.ejmg.2022.104555. Online ahead of print.ABSTRACTDeficiency of Adenosine deaminase 2 (DADA2) is a monogenic inflammatory disease, caused by mutations in ADA2 gene, which encodes an extracellular enzyme acting as a monocyte differentiation factor. DADA2 is first described with the clinical picture resembling polyarteritis nodosa, including livedo racemose, recurrent fever, musculoskeletal complaints. Besides, some patients have cytopenia, lymphoproliferation and mild to moderate immunodeficiency. The most crucial complication of DADA2 is neurological involvement, espe...
Source: European Journal of Medical Genetics - July 1, 2022 Category: Genetics & Stem Cells Authors: Rabia Miray Kisla Ekinci Ozlem Anlas Ozge Ozalp Source Type: research

Self-report of chronic diseases in old-aged individuals: extent of agreement with general practitioner medical records in the German AugUR study
Conclusion Self-reports may be an effective tool to assess diabetes and cancer in observational studies in the old and very old aged. In contrast, self-reports on heart failure, musculoskeletal, kidney or lung diseases may be substantially imprecise.
Source: Journal of Epidemiology and Community Health - October 10, 2022 Category: Epidemiology Authors: Steinkirchner, A. B., Zimmermann, M. E., Donhauser, F. J., Dietl, A., Brandl, C., Koller, M., Loss, J., Heid, I. M., Stark, K. J. Tags: Open access Original research Source Type: research

Changes in coverage among non-elderly adults with chronic diseases following Affordable Care Act implementation
by John D. Goodson, Sara Shahbazi, Zirui Song ImportanceChanges in insurance coverage after the Affordable Care Act (ACA) among non-elderly adults with self-reported chronic conditions across income categories have not been described. ObjectiveTo examine changes in insurance coverage after the ACA among non-elderly adults with chronic conditions across income categories, by geographic region. DesignWe compared self-reported access to health insurance pre-ACA (2010-2013) and post-ACA (2014-2017) for individuals 18-64 years of age with ≥ 2 chronic conditions, including hypertension, heart disease/stroke, emphysema, diabete...
Source: PLoS One - November 30, 2022 Category: Biomedical Science Authors: John D. Goodson Source Type: research

Cardiovascular events risk in patients with systemic autoimmune diseases: a prognostic systematic review and meta-analysis
CONCLUSION: Patients with SAD present an increased risk of CV morbidity and mortality, which should be considered when establishing therapeutic strategies. These findings support the role of systemic inflammation in the development of atherosclerosis-driven disease.PMID:37650912 | DOI:10.1007/s00392-023-02291-4
Source: Clin Med Res - August 31, 2023 Category: Research Authors: Claudia Asenjo-Lobos Leticia Gonz ález Juan Francisco Bulnes Marta Roque Paula Mu ñoz Venturelli Gonzalo Mart ínez Rodríguez Source Type: research

Rationale and design of the Cardiovascular Inflammation Reduction Trial: A test of the inflammatory hypothesis of atherothrombosis
Background: Inflammation plays a fundamental role in atherothrombosis. Yet, whether direct inhibition of inflammation will reduce the occurrence of adverse cardiovascular outcomes is not known.Design: The Cardiovascular Inflammation Reduction Trial (CIRT) (ClinicalTrials.gov NCT01594333) will randomly allocate 7,000 patients with prior myocardial infarction (MI) and either type 2 diabetes or the metabolic syndrome to low-dose methotrexate (target dose 15-20 mg/wk) or placebo over an average follow-up period of 3 to 5 years. Low-dose methotrexate is a commonly used anti-inflammatory regimen for the treatment of rheumatoid a...
Source: American Heart Journal - May 6, 2013 Category: Cardiology Authors: Brendan M. Everett, Aruna D. Pradhan, Daniel H. Solomon, Nina Paynter, Jean MacFadyen, Elaine Zaharris, Milan Gupta, Michael Clearfield, Peter Libby, Ahmed A.K. Hasan, Robert J. Glynn, Paul M. Ridker Tags: Trial Design Source Type: research

Economic Evaluation of Adult Rehabilitation: A Systematic Review and Meta-Analysis of Randomized Controlled Trials in a Variety of Settings
Conclusions: Based on this systematic review and meta-analyses, a single rehabilitation service may not provide health economic benefits for all patient groups and situations. For some patients, inpatient rehabilitation may be the most cost-effective method of providing rehabilitation; yet, for other patients, rehabilitation in the home or community may be the most cost-effective model of care. To achieve cost-effective outcomes, the ideal combination of rehabilitation services and patient inclusion criteria, as well as further data for nonstroke populations, warrants further research.
Source: Archives of Physical Medicine and Rehabilitation - April 5, 2013 Category: Rehabilitation Authors: Natasha Kareem Brusco, Nicholas F. Taylor, Jennifer J. Watts, Nora Shields Tags: Review Articles (Meta-Analyses) Source Type: research

Women who spend too long sitting may die earlier
Conclusion This cohort study looking at the link between sedentary time in postmenopausal women and their risk of death, benefits from its large sample size of almost 100,000 women, and 12 year follow-up. It finds, as previous research has found, that increased sedentary time is generally associated with increased risk of death. The main risk was for women with the highest sedentary time (greater than 11 hours sitting per day) who were at increased risk of death from any cause and deaths from heart disease or cancer compared with women sitting for less than four hours a day. The links were less clear for women sedentary ...
Source: NHS News Feed - January 17, 2014 Category: Consumer Health News Tags: Lifestyle/exercise Heart/lungs Source Type: news