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Xiaoxuming Decoction Regulates Vascular Function by Modulating G Protein-Coupled Receptors: A Molecular Docking Study
In this study, XXMD was found to induce relaxation of the basilar artery rings of rats precontracted by 5-hydroxytryptamine (5-HT) in vitro, in a dose-dependent manner. The modulation of vascular tone and the process of cerebral ischemia are mediated via the interactions between G protein-coupled receptors (GPCRs) and their ligands, including 5-HT, angiotensin II (Ang II), and urotensin II (UII). Thus, the potential synergistic effects of the different components of XXMD on the regulation of vasoconstriction and vasodilation were further investigated by molecular docking based on network pharmacology. We constructed and an...
Source: Biomed Res - July 1, 2021 Category: Research Authors: Yanjia Shen Ran Yang Rui Zhou Wendan Lu Li Li Ziran Niu Miao Chen Jinhua Wang Yuehua Wang Lianhua Fang Guanhua Du Source Type: research

A Network Pharmacology-Based Identification Study on the Mechanism of Xiao-Xu-Ming Decoction for Cerebral Ischemic Stroke.
Conclusion: This study initially clarified the main targets and pathways of XXMD in the treatment of CIS, which can lay the foundation for further research on its pharmacological effects. PMID: 33133212 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - November 3, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Supplements That Save Lives And Bucks
I’m sure I don’t have to tell you about the high cost of medical care these days. The fact is that as costs continue to skyrocket, more and more Americans are driven into bankruptcy, because they cannot pay their medical bills. Too often, they even lose their homes. You may have even lost a neighbor to this disturbing trend. It may have even happened to you – although, I certainly hope not. That’s one reason I have always dedicated myself to keeping my patients out of hospitals – which often see patients as cash cows, instead of human beings. And a cornerstone of this philosophy has been based upon pr...
Source: Al Sears, MD Natural Remedies - June 3, 2015 Category: Complementary Medicine Authors: Dr. Al Sears Tags: Nutrition supplements vitamins Source Type: news