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The Nutritional Supplement L-Alpha Glycerylphosphorylcholine Promotes Atherosclerosis
Int J Mol Sci. 2021 Dec 15;22(24):13477. doi: 10.3390/ijms222413477.ABSTRACTL-alpha glycerylphosphorylcholine (GPC), a nutritional supplement, has been demonstrated to improve neurological function. However, a new study suggests that GPC supplementation increases incident stroke risk thus its potential adverse effects warrant further investigation. Here we show that GPC promotes atherosclerosis in hyperlipidemic Apoe-/- mice. GPC can be metabolized to trimethylamine N-oxide, a pro-atherogenic agent, suggesting a potential molecular mechanism underlying the observed atherosclerosis progression. GPC supplementation shifted t...
Source: Atherosclerosis - December 24, 2021 Category: Cardiology Authors: Zeneng Wang Jennie Hazen Xun Jia Elin Org Yongzhong Zhao Lucas J Osborn Nisreen Nimer Jennifer Buffa Miranda K Culley Daniel Krajcik Bert-Jan H van den Born Koos Zwinderman Bruce S Levison Max Nieuwdorp Aldons J Lusis Joseph A DiDonato Stanley L Hazen Source Type: research

Plant-Derived Alkaloids: The Promising Disease-Modifying Agents for Inflammatory Bowel Disease
Conclusion This paper summarizes the current findings regarding the anti-colitis activity of plant-derived alkaloids and shows how these alkaloids exhibit significant and beneficial effects in alleviating colonic inflammation. These natural alkaloids are not only promising agents for IBD treatment but are also components for developing new wonder drugs. However, the underlying molecular mechanisms or toxicological evaluation of most plant-derived alkaloids still require much scientific research, and their actual efficacies for IBD patients have not been verified well in field research. Thus, further clinical trials to elu...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research