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Iron, Ferroptosis, and Ischemic Stroke
AbstractOver 30 million people suffer from the consequences of ischemic stroke. The precise molecular mechanism of neuronal damage during ischemic stroke remains unclear; therefore, the effective treatment of post-ischemic stroke remains a critical challenge. Recently, iron has emerged as a crucial factor in post-reperfusion injuries, participating in cell peroxidation, excitotoxicity, and a distinctive cell death pathway, namely ferroptosis. Since iron is tightly regulated in the brain and important for brain functions, the imbalance of its metabolism, including its overload and deficiency, has been shown to impact ischem...
Source: Journal of Neurochemistry - March 13, 2023 Category: Neuroscience Authors: Jun Guo, Qing ‐zhang Tuo, Peng Lei Tags: REVIEW Source Type: research

Srs11-92, a ferrostatin-1 analog, improves oxidative stress and neuroinflammation via Nrf2 signal following cerebral ischemia/reperfusion injury
CONCLUSION: The findings imply that Fer-1 analog AA9 may be suitable for further translational studies for the protection of neuronal damage via Nrf2 signal pathway-mediated oxidative stress and neuroinflammation in stroke and others neurological diseases.PMID:36852441 | DOI:10.1111/cns.14130
Source: CNS Neuroscience and Therapeutics - February 28, 2023 Category: Neuroscience Authors: Yuhua Chen Wei He Hong Wei Cuicui Chang Lingjian Yang Jiao Meng Tianlin Long Quanhua Xu Chi Zhang Source Type: research

The Role of Ferroptosis in Nervous System Disorders
J Integr Neurosci. 2023 Jan 16;22(1):19. doi: 10.31083/j.jin2201019.ABSTRACTFerroptosis is distinct from other apoptotic forms of programmed cell death and is characterized by the accumulation of iron and lipid peroxidation. Iron plays a crucial role in the oxidation of lipids via the Fenton reaction with oxygen. Hence, iron accumulation causes phospholipid peroxidation which induces ferroptosis. Moreover, detoxification by glutathione is disrupted during ferroptosis. A growing number of studies have implicated ferroptosis in nervous system disorders such as depression, neurodegenerative disease, stroke, traumatic brain in...
Source: Journal of Integrative Neuroscience - February 1, 2023 Category: Neuroscience Authors: Lixia Du You Wu Zhongmin Fan Yi Li Xiaofeng Guo Zongping Fang Xijing Zhang Source Type: research

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