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Sex differences in hearing impairment due to diet-induced obesity in CBA/Ca mice
ConclusionsFemale mice are more resistant to the negative effects of an HFD on body weight, metabolism, and hearing. Females showed increased peripheral and intra-cochlear adiponectin and AdipoR1 levels, and HC ribbon synapses. These changes may mediate resistance to HFD-induced hearing loss seen in female mice.
Source: Biology of Sex Differences - February 21, 2023 Category: Biology Source Type: research

Resolution of inflammation is disturbed in acute ischemic stroke with diabetes mellitus and rescued by resolvin D2 treatment
CONCLUSIONS: Our data demonstrate resolution of inflammation is impaired by DM in AIS patients, implicating a novel mechanism of un-resolved inflammation in DM-related AIS. Furthermore, RvD2 promotes inflammation resolution in macrophages/microglia and protects DM-related AIS, and may thus serve as a novel therapeutic target.PMID:35750271 | DOI:10.1016/j.freeradbiomed.2022.06.231
Source: Free Radical Biology and Medicine - June 24, 2022 Category: Biology Authors: Xin Tang Lan Liu Zhijuan Miao Jiawei Zhang Xiaolong Cai Bing-Qiao Zhao Gefei Chen Marianne Schultzberg Yuwu Zhao Xiuzhe Wang Source Type: research

Cardiac hypertrophy with obesity is augmented after pregnancy in C57BL/6 mice
ConclusionsThese results suggest that the combined effects of pregnancy and obesity augment cardiac hypertrophy and promote remodeling. The rising prevalence of CVD in premenopausal women may be attributed to an increased prevalence of women entering pregnancy with an overweight or obese BMI.
Source: Biology of Sex Differences - December 15, 2019 Category: Biology Source Type: research