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Research trends in flavonoids and health.
Abstract Herein we describe, based on some bibliometric data, how the field of research on flavonoids has evolved over the last 25 years. The number of papers on flavonoids has risen in an exponential manner over these years, much faster than other fields on food constituents. This increase appears to be related to the contemporary explosion of interest in healthy foods, supplements and nutraceuticals. It was also probably triggered by large epidemiological studies on fruits and vegetables, and particularly on flavonoids, consumption and incidence of cancer, stroke and coronary heart disease. The widely distribute...
Source: Archives of Biochemistry and Biophysics - March 23, 2018 Category: Biochemistry Authors: Perez-Vizcaino F, Fraga CG Tags: Arch Biochem Biophys Source Type: research

Rutin attenuates cerebral ischemia/reperfusion injury in ovariectomized rats via estrogen receptor-mediated BDNF-TrkB and NGF-TrkA signaling.
This study was performed to investigate whether rutin could protect against cerebral ischemia by modulating ER pathway. Ovariectomized (OVX) rats were given intraperitoneal injection of vehicle (DMSO), rutin (100 mg/kg) or 17β-estradiol (100 μg/kg) for 5 continuous days. Then, the rats were subjected to middle cerebral artery occlusion (MCAO) for 1 h followed by a 24-h reperfusion to establish the cerebral ischemia/reperfusion (I/R) injury. We found that rutin improved the sensorimotor performance and recognition memory of I/R rats, decreased the infarct size and attenuated the neuron loss. Rutin treatment also increased...
Source: Biochemistry and Cell Biology - February 8, 2018 Category: Biochemistry Authors: Liu H, Zhong L, Zhang Y, Liu X, Li J Tags: Biochem Cell Biol Source Type: research

The effect of Scutellaria baicalensis stem-leaf flavonoids on spatial learning and memory in chronic cerebral ischemia-induced vascular dementia of rats.
Abstract Flavonoids have been shown to improve cognitive function and delay the dementia progression. However, the underlying mechanisms remain elusive. In the present study, we examined the effect of Scutellaria baicalensis stem-leaf total flavonoids (SSTFs) extracted from S. baicalensis Georgi on spatial learning and memory in a vascular dementia (VaD) rat model and explored its molecular mechanisms. The VaD rats were developed by permanent bilateral occlusion of the common carotid artery. Seven days after recovery, the VaD rats were treated with either 50 or 100 mg/kg of SSTF for 60 days. The spatial learning a...
Source: Acta Biochimica et Biophysica Sinica - April 25, 2016 Category: Biochemistry Authors: Cao Y, Liang L, Xu J, Wu J, Yan Y, Lin P, Chen Q, Zheng F, Wang Q, Ren Q, Gou Z, Du Y Tags: Acta Biochim Biophys Sin (Shanghai) Source Type: research