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Total 172 results found since Jan 2013.

Gut microbes impact stroke severity via the trimethylamine N-oxide pathway
Cell Host Microbe. 2021 Jun 10:S1931-3128(21)00230-4. doi: 10.1016/j.chom.2021.05.002. Online ahead of print.ABSTRACTClinical studies have demonstrated associations between circulating levels of the gut-microbiota-derived metabolite trimethylamine-N-oxide (TMAO) and stroke incident risk. However, a causal role of gut microbes in stroke has not yet been demonstrated. Herein we show that gut microbes, through dietary choline and TMAO generation, directly impact cerebral infarct size and adverse outcomes following stroke. Fecal microbial transplantation from low- versus high-TMAO-producing human subjects into germ-free mice s...
Source: Cell Host and Microbe - June 17, 2021 Category: Microbiology Authors: Weifei Zhu Kymberleigh A Romano Lin Li Jennifer A Buffa Naseer Sangwan Prem Prakash Aaron N Tittle Xinmin S Li Xiaoming Fu Charlie Androjna Anthony J DiDonato Kimberly Brinson Bruce D Trapp Michael A Fischbach Federico E Rey Adeline M Hajjar Joseph A DiDo Source Type: research

The Modified Chronic Kidney Disease Epidemiology Collaboration Equation for the Estimated Glomerular Filtration Rate is Better Associated with Comorbidities than Other Equations in Living Kidney Donors in Japan
Conclusion We found that the eGFR/Jm-CKD-EPI correlated better with comorbidities than the eGFR/Jm-eGFR and eGFR/Jm-MDRD in Japanese LKT donors. We recommend using the eGFR/Jm-CKD-EPI for the initial assessment of the renal function in LKT donor candidates when evaluating the presence of associated comorbidities.PMID:33716291 | DOI:10.2169/internalmedicine.6934-20
Source: Internal Medicine - March 15, 2021 Category: Internal Medicine Authors: Shinichi Nishi Shunske Goto Makiko Mieno Takashi Yagisawa Kenji Yuzawa Source Type: research

Akebia saponin D ameliorates metabolic syndrome (MetS) via remodeling gut microbiota and attenuating intestinal barrier injury
Biomed Pharmacother. 2021 Feb 27;138:111441. doi: 10.1016/j.biopha.2021.111441. Online ahead of print.ABSTRACTMetabolic syndrome (MetS) is a complex, multifactorial disease which lead to an increased risk of cardiovascular disease, type 2 diabetes, and stroke. However, selective, and potent drugs for the treatment of MetS are still lacking. Previous studies have found that Akebia saponin D (ASD) has beneficial effects on metabolic diseases such as obesity, atherosclerosis, and non-alcoholic fatty liver disease (NAFLD). Therefore, our study was designed to determine the effect and mechanism of action of ASD against MetS in ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 2, 2021 Category: Drugs & Pharmacology Authors: Song Yang Ting Hu He Liu Ya-Li Lv Wen Zhang Han Li Lingling Xuan Li-Li Gong Li-Hong Liu Source Type: research

Gut dysbiosis and age-related neurological diseases; an innovative approach for therapeutic interventions.
GUT DYSBIOSIS AND AGE-RELATED NEUROLOGICAL DISEASES; AN INNOVATIVE APPROACH FOR THERAPEUTIC INTERVENTIONS. Transl Res. 2020 Aug 02;: Authors: Holmes A, Finger C, Morales-Scheihing D, Lee J, McCullough LD Abstract The gut microbiota is a complex ecosystem of bacteria, fungi, and viruses that acts as a critical regulator in microbial, metabolic, and immune responses in the host organism. Imbalances in the gut microbiota, termed "dysbiosis", often induce aberrant immune responses, which in turn disrupt the local and systemic homeostasis of the host. Emerging evidence has highlighted the importance of gut...
Source: Translational Research : the journal of laboratory and clinical medicine - August 1, 2020 Category: Laboratory Medicine Authors: Holmes A, Finger C, Morales-Scheihing D, Lee J, McCullough LD Tags: Transl Res Source Type: research

Challenge to the Intestinal Mucosa During Sepsis
Conclusion The impact of sepsis on the gut is manifold, e.g., sepsis mediated alteration of the gut-blood barrier and increase in the intestinal permeability, which may correlate with the phenomena of bacterial translocation and lymphatic activation (“toxic-lymph”). Systemic consequences of sepsis are widespread and concern to the coagulative system, the microbiome as well as enzymes, such as pancreatic proteases, MMPs and IAPs. Nevertheless, the therapeutic approaches for modulating the mucosal immune system are still rarely effective in daily routine. Recent published studies showing that treatment with ...
Source: Frontiers in Immunology - April 29, 2019 Category: Allergy & Immunology Source Type: research