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Orally Administered Crocin Protects Against Cerebral Ischemia/Reperfusion Injury Through the Metabolic Transformation of Crocetin by Gut Microbiota
Conclusion Collectively, pharmacokinetic and pharmacodynamic association studies provide evidence that the gut microbiota plays a vital role in the fate of crocin and crocetin in the gastrointestinal tract. In addition, the cross-interaction between gut microbiota and crocin might mediate the activation of the cerebral-protective effect of orally administered crocin. Ethics Statement This study was carried out in accordance with the recommendations of ‘Institutional Animal Research Committee guidelines, Animal Ethics Committee of China Pharmaceutical University.’ The protocol was approved by the ‘An...
Source: Frontiers in Pharmacology - April 29, 2019 Category: Drugs & Pharmacology Source Type: research

Does diet map with mortality? Ecological association of dietary patterns with chronic disease mortality and its spatial dependence in Switzerland
Br J Nutr. 2021 May 11:1-27. doi: 10.1017/S0007114521001525. Online ahead of print.ABSTRACTThe aim of the study was to investigate the associations between dietary patterns and chronic disease mortality in Switzerland using an ecologic design and to explore the spatial dependence of these associations, i.e. the tendency of near locations to present more similar values than randomly expected and distant locations to present more different values. Data of the cross-sectional National Nutrition Survey menuCH (n = 2,057) were used to compute hypothesis- (Alternate Healthy Eating Index, AHEI) and data-driven dietary patterns. D...
Source: The British Journal of Nutrition - May 11, 2021 Category: Nutrition Authors: Giulia Pestoni Nena Karavasiloglou Julia Braun Jean-Philippe Krieger Janice M Sych Matthias Bopp David Faeh Oliver Gruebner Sabine Rohrmann Source Type: research