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Association of chocolate consumption with neurological and cardiovascular outcomes in atrial fibrillation: data from two Swiss atrial fibrillation cohort studies (Swiss-AF and BEAT-AF)
CONCLUSION: While chocolate consumption was not associated with MRI findings and major adverse cardiac events in an atrial fibrillation population, No/Low-Ch was associated with a lower cognitive construct score, higher risk of heart failure hospitalisation and increased all-cause mortality compared to Mod-Ch.CLINICALTRIALS: gov Identifier: NCT02105844.PMID:37609948 | DOI:10.57187/smw.2023.40109
Source: Swiss Medical Weekly - August 23, 2023 Category: General Medicine Authors: Annina Stauber Andreas M üller Nikki Rommers Stefanie Aeschbacher Nicolas Rodondi Leo H Bonati Juerg H Beer Raban V Jeger David J Kurz Claudia Liedtke Peter Ammann Marcello Di Valentino Patricia Chocano Richard Kobza Michael K ühne David Conen Stefan Os Source Type: research

Neuroprotective effects of theobromine in transient global cerebral ischemia-reperfusion rat model
In this study, neuroprotective potential of theobromine (TBR) was evaluated in 2-vessel occlusion transient global cerebral ischemia-reperfusion (tGCI/R) rat model. Rats were treated with TBR (50, 100 mg/kg, p.o.) for 7 successive days, and subjected to bilateral common carotid artery occlusion (20 min) or sham surgery after last dose of TBR. Severe neurological deficits accompanied by brain infarction, blood-brain barrier abnormalities, and oedema were noted in rats subjected to tGCI/R, and these effects were prevented by TBR. TBR protected against lipid peroxidation and enhanced glutathione level in brain against tGCI/R....
Source: Biochemical and Biophysical Research communications - July 25, 2021 Category: Biochemistry Authors: Javeed Ahmad Bhat Sushma Gupta Manish Kumar Source Type: research

Plant-Derived Alkaloids: The Promising Disease-Modifying Agents for Inflammatory Bowel Disease
Conclusion This paper summarizes the current findings regarding the anti-colitis activity of plant-derived alkaloids and shows how these alkaloids exhibit significant and beneficial effects in alleviating colonic inflammation. These natural alkaloids are not only promising agents for IBD treatment but are also components for developing new wonder drugs. However, the underlying molecular mechanisms or toxicological evaluation of most plant-derived alkaloids still require much scientific research, and their actual efficacies for IBD patients have not been verified well in field research. Thus, further clinical trials to elu...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research