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Total 32 results found since Jan 2013.
Icaritin inhibits neuroinflammation in a rat cerebral ischemia model by regulating microglial polarization through the GPER-ERK-NF- κB signaling pathway
CONCLUSIONS: These findings indicate that ICT plays roles in inhibiting the inflammatory response and achieving neuroprotection by regulating GPER-ERK-NF-κB signaling and then inhibiting microglial activation and M1 polarization while promoting M2 polarization, which provides a new therapeutic for against cerebral ischemic stroke.PMID:36447154 | DOI:10.1186/s10020-022-00573-7
Source: Molecular Medicine - November 29, 2022 Category: Molecular Biology Authors: Zining Yu Guangjun Su Limei Zhang Gaigai Liu Yonggang Zhou Shicai Fang Qian Zhang Tianyun Wang Cheng Huang Zhihua Huang Liangdong Li Source Type: research
Antihypertension effect of astragaloside IV during cerebral ischemia reperfusion in rats
In conclusion, astragaloside IV may alleviate CIR injury partially by lowering systemic blood pressure.PMID:36331022 | DOI:10.3892/mmr.2022.12890
Source: Molecular Medicine - November 4, 2022 Category: Molecular Biology Authors: Fengyan Shen Yong Meng Yuhai He Bowan Huang Jinxin Huang Lu Wang Source Type: research
Mechanism of ischemic brain injury repair by endothelial progenitor cell ‑derived exosomes
Mol Med Rep. 2022 Aug;26(2):269. doi: 10.3892/mmr.2022.12785. Epub 2022 Jul 1.ABSTRACTIschemic stroke is a refractory disease that seriously endangers human health and life. The main treatment aim of stroke is to alleviate brain injury. The present study aimed to investigate the effects and mechanisms of endothelial progenitor cell (EPC)‑derived exosomes in repairing ischemic brain injury. Sprague‑Dawley rat models of cerebral ischemia‑reperfusion (IR) injury were established by middle cerebral artery occlusion. The IR model rats were then treated with PBS, EPC or exosomes; untreated and Sham rats were used as contro...
Source: Molecular Medicine - July 1, 2022 Category: Molecular Biology Authors: Rui Huang Tianxiang Cheng Xianliang Lai Source Type: research
AKT/GSK-3 β signaling is altered through downregulation of mTOR during cerebral Ischemia/Reperfusion injury
CONCLUSION: Our findings provide new insight into the cellular responses to ischemia/reperfusion brain injury and will help develop new treatments targeting the AKT signaling pathway for the treatment of ischemic stroke.PMID:35235160 | DOI:10.1007/s11033-022-07247-x
Source: Molecular Biology Reports - March 2, 2022 Category: Molecular Biology Authors: Shengwei Peng Jin-Hua Gu Chun-Ling Dai Khalid Iqbal Fei Liu Cheng-Xin Gong Source Type: research
