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Connectivity map identifies luteolin as a treatment option of ischemic stroke by inhibiting MMP9 and activation of the PI3K/Akt signaling pathway.
This study aimed to explore potential new drugs in the treatment of ischemic stroke by Connectivity Map (CMap) and to determine the role of luteolin on ischemic stroke according to its effects on matrix metalloproteinase-9 (MMP9) and PI3K/Akt signaling pathway. Based on published gene expression data, differentially expressed genes were obtained by microarray analysis. Potential compounds for ischemic stroke therapy were obtained by CMap analysis. Cytoscape and gene set enrichment analysis (GSEA) were used to discover signaling pathways connected to ischemic stroke. Cell apoptosis and viability were, respectively, evaluate...
Source: Molecular Medicine - March 24, 2019 Category: Molecular Biology Authors: Luo S, Li H, Mo Z, Lei J, Zhu L, Huang Y, Fu R, Li C, Huang Y, Liu K, Chen W, Zhang L Tags: Exp Mol Med Source Type: research

Intracarotid cold saline infusion contributes to neuroprotection in MCAO ‑induced ischemic stroke in rats via serum and glucocorticoid‑regulated kinase 1.
Intracarotid cold saline infusion contributes to neuroprotection in MCAO‑induced ischemic stroke in rats via serum and glucocorticoid‑regulated kinase 1. Mol Med Rep. 2019 Aug 21;: Authors: Wang D, Huang Z, Li L, Yuan Y, Xiang L, Wu X, Ni C, Yu W Abstract Intracarotid cold saline infusion (ICSI) brings about neuroprotective effects in ischemic stroke. However, the involvement of serum and glucocorticoid‑regulated kinase 1 (SGK1) in the underlying mechanism of ICSI is not fully understood; therefore, we used the rat middle cerebral artery occlusion (MCAO) model to investigate the neuroprotective ...
Source: Molecular Medicine Reports - September 7, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

AKT/GSK-3 β signaling is altered through downregulation of mTOR during cerebral Ischemia/Reperfusion injury
CONCLUSION: Our findings provide new insight into the cellular responses to ischemia/reperfusion brain injury and will help develop new treatments targeting the AKT signaling pathway for the treatment of ischemic stroke.PMID:35235160 | DOI:10.1007/s11033-022-07247-x
Source: Molecular Biology Reports - March 2, 2022 Category: Molecular Biology Authors: Shengwei Peng Jin-Hua Gu Chun-Ling Dai Khalid Iqbal Fei Liu Cheng-Xin Gong Source Type: research

Mechanism of ischemic brain injury repair by endothelial progenitor cell ‑derived exosomes
Mol Med Rep. 2022 Aug;26(2):269. doi: 10.3892/mmr.2022.12785. Epub 2022 Jul 1.ABSTRACTIschemic stroke is a refractory disease that seriously endangers human health and life. The main treatment aim of stroke is to alleviate brain injury. The present study aimed to investigate the effects and mechanisms of endothelial progenitor cell (EPC)‑derived exosomes in repairing ischemic brain injury. Sprague‑Dawley rat models of cerebral ischemia‑reperfusion (IR) injury were established by middle cerebral artery occlusion. The IR model rats were then treated with PBS, EPC or exosomes; untreated and Sham rats were used as contro...
Source: Molecular Medicine - July 1, 2022 Category: Molecular Biology Authors: Rui Huang Tianxiang Cheng Xianliang Lai Source Type: research

Antihypertension effect of astragaloside  IV during cerebral ischemia reperfusion in rats
In conclusion, astragaloside IV may alleviate CIR injury partially by lowering systemic blood pressure.PMID:36331022 | DOI:10.3892/mmr.2022.12890
Source: Molecular Medicine - November 4, 2022 Category: Molecular Biology Authors: Fengyan Shen Yong Meng Yuhai He Bowan Huang Jinxin Huang Lu Wang Source Type: research

CPCGI confers neuroprotection by enhancing blood circulation and neurological function in cerebral ischemia/reperfusion rats.
Authors: Miao Y, Wang R, Wu H, Yang S, Qiu Y Abstract The current study used a rat middle cerebral artery occlusion (MCAO) model with the aim to explore the effects of compound porcine cerebroside and ganglioside injection (CPCGI) on brain ischemia/reperfusion injury in rats. Improvement in the infarct‑side microcirculation and the overall recovery of neurological function were detected by triphenyltetrazolium chloride staining, laser speckle blood flow monitoring, latex perfusion, immunofluorescence and immunoblotting. The results revealed that administration of CPCGI for 7 consecutive days following ischemic ...
Source: Molecular Medicine Reports - July 21, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Antihypertension effect of astragaloside  IV during cerebral ischemia reperfusion in rats
In conclusion, astragaloside IV may alleviate CIR injury partially by lowering systemic blood pressure.PMID:36331022 | DOI:10.3892/mmr.2022.12890
Source: Molecular Medicine Reports - November 4, 2022 Category: Molecular Biology Authors: Fengyan Shen Yong Meng Yuhai He Bowan Huang Jinxin Huang Lu Wang Source Type: research

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