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The economic burden of stroke: a systematic review of cost of illness studies
J Med Life. 2021 Sep-Oct;14(5):606-619. doi: 10.25122/jml-2021-0361.ABSTRACTStroke is one of the leading causes of morbidity and mortality worldwide. As the number of stroke cases is rising from one year to another, policymakers require data on the amount spent on stroke to enforce better financing policies for prevention, hospital care, outpatient rehabilitation services and social services. We aimed to systematically assess the economic burden of stroke at global level. Cost of stroke studies were retrieved from five databases. We retrieved the average cost per patient, where specified, or estimated it using a top-down a...
Source: Journal of Medicine and Life - January 14, 2022 Category: General Medicine Authors: Stefan Strilciuc Diana Alecsandra Grad Constantin Radu Diana Chira Adina Stan Marius Ungureanu Adrian Gheorghe Fior-Dafin Muresanu Source Type: research

Anticoagulant choice in antiphospholipid syndrome – associated thrombosis
Background: DOACs have largely replaced VKAs as first-line therapy for venous thromboembolism in patients with adequate renal function. However, there is concern in APS that DOACs may have higher rates of recurrent thrombosis than VKAs when treating thromboembolism. Dr. David Portnoy Study design: Randomized noninferiority trial. Setting: Six teaching hospitals in Spain. Synopsis: Of adults with thrombotic APS, 190 were randomized to receive rivaroxaban or warfarin. Primary outcomes were thrombotic events and major bleeding. Follow-up after 3 years demonstrated new thromboses in 11 patients (11.6%) in the DOAC...
Source: The Hospitalist - December 10, 2021 Category: Hospital Management Authors: Daniel Hickman Tags: Hematology Thrombosis Source Type: research

IJERPH, Vol. 18, Pages 12877: Early Occupational Therapy Intervention in the Hospital Discharge after Stroke
osme Stroke is the leading cause of acquired disability in adults which is a cerebrovascular disease of great impact in health and social terms, not only due to its prevalence and incidence but also because of its significant consequences in terms of patient dependence and its consequent impact on the patient and family lives. The general objective of this study is to determine whether an early occupational therapy intervention at hospital discharge after suffering a stroke has a positive effect on the functional independence of the patient three months after discharge—the patient’s level of...
Source: International Journal of Environmental Research and Public Health - December 7, 2021 Category: Environmental Health Authors: Patricia Garc ía-Pérez Mar ía del Carmen Rodríguez-Martínez Jos é Pablo Lara Carlos de la Cruz-Cosme Tags: Study Protocol Source Type: research

Cost-effectiveness of upper extremity dry needling in the rehabilitation of patients with stroke
DISCUSSION: Cost-effectiveness with responder rate results were favourable for the DN group and were confirmed by the sensitivity analysis according to levels of care. In addition, our findings revealed that 4 weeks of treatment could be more cost-effective than 8 weeks. DN treatment of the upper extremity appears to be cost-effective based on the rate of responders measured using the MMAS scale.PMID:34856821 | DOI:10.1177/09645284211055750
Source: Acupuncture in Medicine : journal of the British Medical Acupuncture Society - December 3, 2021 Category: Complementary Medicine Authors: Daniel Fern ández Sanchis Juan Nicol ás Cuenca Zaldívar Sandra Calvo Pablo Herrero Manuel G ómez Barrera Source Type: research

Effect of the COVID-19 pandemic in stroke code activations in the region of Madrid: A retrospective study
Acute sstroke is the most common time-dependent disease attended in the emergency medical service (EMS) of Madrid (SUMMA 112). Community of Madrid has been one of the most affected regions in Spain by the coronavirus disease 2019 (COVID-19) pandemic. A significant reduction in acute sstroke hospital admissions has been reported during the COVID-19 pandemic compared to the same period 1 year before. As international clinical practice guidelines support those patients with suspected acute stroke should be accessed via EMS, it is important to know whether the pandemic has jeopardized urgent pre-hospital stroke care, the first...
Source: Medicine - October 29, 2021 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Allogeneic adipose tissue-derived mesenchymal stem cells in ischaemic stroke (AMASCIS-02): a phase IIb, multicentre, double-blind, placebo-controlled clinical trial protocol
Introduction Stroke is a serious public health problem, given it is a major cause of disability worldwide despite the spread of recanalisation therapies. Enhancement of brain plasticity with stem cell administration is a promising innovative therapy to reduce sequelae in these patients. Methods and analysis We have developed a phase IIb, multicentre, randomised, double-blind, placebo-controlled clinical trial protocol to evaluate the safety and efficacy of intravenous administration of allogeneic adipose tissue-derived mesenchymal stem cells (AD-MSCs) in patients with acute ischaemic stroke, concurrently with conventional...
Source: BMJ Open - August 9, 2021 Category: General Medicine Authors: de Celis-Ruiz, E., Fuentes, B., Moniche, F., Montaner, J., Borobia, A. M., Gutierrez-Fernandez, M., Diez-Tejedor, E. Tags: Open access, Neurology Source Type: research

DNA methylation analyses identify an intronic < i > ZDHHC6 < /i > locus associated with time to recurrent stroke in the Vitamin Intervention for Stroke Prevention (VISP) clinical trial
by Nicole M. Davis Armstrong, Wei-Min Chen, Fang-Chi Hsu, Michael S. Brewer, Natalia Cullell, Israel Fern ández-Cadenas, Stephen R. Williams, Michèle M. Sale, Bradford B. Worrall, Keith L. Keene Aberrant DNA methylation profiles have been implicated in numerous cardiovascular diseases; however, few studies have investigated how these epigenetic modifications contribute to stroke recurrence. The aim of this study was to identify methylation loci associated with the time to recurrent cerebr o- and cardiovascular events in individuals of European and African descent. DNA methylation profiles were generated for 180 individu...
Source: PLoS One - July 12, 2021 Category: Biomedical Science Authors: Nicole M. Davis Armstrong Source Type: research

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