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Rivaroxaban for Preventing Atherothrombotic Events in People with Acute Coronary Syndrome and Elevated Cardiac Biomarkers: An Evidence Review Group Perspective of a NICE Single Technology Appraisal
Abstract As part of its Single Technology Appraisal process, the National Institute for Health and Care Excellence (NICE) invited the company that manufactures rivaroxaban (Xarelto, Bayer) to submit evidence of the clinical and cost effectiveness of rivaroxaban for the prevention of adverse outcomes in patients after the acute management of acute coronary syndrome (ACS). The School of Health and Related Research Technology Appraisal Group at the University of Sheffield was commissioned to act as the independent Evidence Review Group (ERG). The ERG produced a critical review of the evidence for the clinical and cos...
Source: PharmacoEconomics - December 21, 2015 Category: Health Management Source Type: research

Heparin, grad students, a clinical revolution and giving credit where it's due
The story of a grad student who overcame remarkable odds only to be denied his moment of glory, or a tale of dark deceit and devilish doings? The story of heparin is as complicated as the chemistry itselfBlood is remarkable.A liquid that carries nutrients, waste products and the ever-vigilant cells of the immune system around the body, blood rapidly turns into a solid when it leaves its veins and arteries and becomes exposed to bodily tissues or the air outside. This process of solidification – clotting, or coagulation – is executed and controlled by a complex set of reactions and interactions primarily involving the e...
Source: Guardian Unlimited Science - September 4, 2013 Category: Science Authors: Richard P Grant Tags: theguardian.com Blogposts Science Source Type: news

Can Data Simulation Help Evaluate Hta Outcomes Over Time and Facilitate Early Decision-Making? a Case Study of Ticagrelor in Acute Coronary Syndrome in the Uk
In October 2011, the National Institute for Health and Care Excellence (NICE) recommended the use of ticagrelor in adult patients presenting with acute coronary syndrome (ACS) in England and Wales. The relative effectiveness and cost-effectiveness of ticagrelor compared to clopidogrel—the current standard of care in the NHS—were based on results from one large multicentre study including over 18,000 ACS patients. Patients were recruited from October 2006 through to July 2008 and primary trial data analysis, published in September 2009, demonstrated that ticagrelor significantly reduced the rate of death, myocardial inf...
Source: Value in Health - October 23, 2015 Category: Global & Universal Authors: P Dequen, NJ Cooper, K Abrams Source Type: research