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Plant-Derived Alkaloids: The Promising Disease-Modifying Agents for Inflammatory Bowel Disease
Conclusion This paper summarizes the current findings regarding the anti-colitis activity of plant-derived alkaloids and shows how these alkaloids exhibit significant and beneficial effects in alleviating colonic inflammation. These natural alkaloids are not only promising agents for IBD treatment but are also components for developing new wonder drugs. However, the underlying molecular mechanisms or toxicological evaluation of most plant-derived alkaloids still require much scientific research, and their actual efficacies for IBD patients have not been verified well in field research. Thus, further clinical trials to elu...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research

Botany, traditional use, phytochemistry, pharmacology, quality control, and authentication of Radix Gentianae Macrophyllae-A traditional medicine: A review
Conclusions: Although the identification of compounds from Qinjiao and demonstration of medicinal uses in vitro and in vivo have been carried out, various other studies on these plants should deserve our more attention. More efforts should be concentrated on the underlying mechanisms of their beneficial bioactivities. The proper toxic evaluation is indispensable to guarantee the safety, efficacy, and eligibility for medical use. To sum up, the summarized achievements could highlight the importance of Qinjiao and provide a solid foundation for scientists not only to further exploit the therapeutic potentials, but also possi...
Source: Phytomedicine - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Business Office Feature The Art and Science of Traditional Medicine Part 2: Multidisciplinary Approaches for Studying Traditional Medicine
In this second of three special supplements, herbal genomics as a novel approach for revolutionizing research on, and ultimately use of, traditional herbal medicines and other materia medica, as well as advances in their quality control and standardization, is highlighted. A prominent focus is the U.S. Food and Drug Administration’s practical framework for developing botanicals (including traditional medicines) into new drugs based on the same standards as small molecule drugs. The application of mechanistic studies to drug discovery and development from traditional therapies is discussed, with an emphasis on preclinical...
Source: Science: Current Issue - January 15, 2015 Category: Science Authors: Science Magazine (mailto:soleditor at aaas.org) Tags: CUSTOM PUBLISHING OFFICE SPONSORED SUPPLEMENT Source Type: research