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532 Shingles and post-herpetic neuralgia (PHN) in post-stroke patients: Real-world evidence
Shingles, known as zoster or herpes zoster, is a neurotropic viral disease featured with painful dermatomal skin eruptions, which leads to a notorious complication, post-herpetic neuralgia (PHN). PHN are usually refractory to treatment and disturbs patients' life. Among the world, stroke is a main cause of morbidity and mortality. Since patients are prone to get infectious diseases during acute phase following stroke, this study is aimed to investigate whether stroke increases the risk of shingles and it's terrible complication, PHN.
Source: Journal of Investigative Dermatology - April 17, 2023 Category: Dermatology Authors: C. Wu, Y. Lu Source Type: research

Herpes zoster ophthalmicus with associated vasculopathy causing stroke. Antia, Camila; Persad, Leah; Alikhan, Ali
Varicella zoster virus (VZV) is an exclusively human, double-stranded DNA virus. Primary infection causes varicella (chickenpox); later the virus becomes dormant in the dorsal root, cranial nerve, and autonomic ganglia along the entire span of the nervous system, retaining the capacity to reactivate and cause a variety of dermal and neurological complications. Recently there has been increasing recognition, both clinically and epidemiologically, of the relationship between VZV and subsequent strokes. Herein, we describe a case of a previously healthy individual with reactivation of VZV causing herpes zoster opthtalmicus al...
Source: Dermatology Online Journal - July 22, 2017 Category: Dermatology Source Type: research

Stroke risk rose in autoimmune disease patients after herpes zoster
Stroke risk was 50% higher in the month after patients with autoimmune diseases developed herpes zoster, compared with the next 2-6 years, according to Dr. Leonard H. Calabrese. “These data provide urgency for developing strategies to reduce the risk of varicella zoster virus in vulnerable...
Source: Skin and Allergy News - November 8, 2015 Category: Dermatology Source Type: news

The immunocompromised district in dermatology: A unifying pathogenic view of the regional immune dysregulation
Abstract: Besides the systemic immune deficiency, a sectorial default in immune control may occur in immunocompetent subjects. This regional immune defect can appear and remain confined to differently damaged skin areas, lately labeled immunocompromised districts (ICDs).An ICD is a skin area more vulnerable than the rest of the body for genetic or acquired reasons. Its vulnerability mainly consists in a local dysregulation of the immune control, which often facilitates (but sometimes hinders) the local onset of immunity-related eruptions or skin disorders.The factors responsible for localized immune dysregulation are multi...
Source: Clinics in Dermatology - August 25, 2014 Category: Dermatology Authors: Vincenzo Ruocco, Eleonora Ruocco, Vincenzo Piccolo, Giampiero Brunetti, Luigi Pio Guerrera, Ronni Wolf Source Type: research