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Specialty: Dermatology
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Total 354 results found since Jan 2013.
Cardiovascular comorbidities in atopic dermatitis: Potential implications for the use of Janus kinase inhibitors
To the Editor: The Food and Drug Administration recently approved the use of 2 oral Janus kinase (JAK) inhibitors —abrocitinib and upadacitinib—for patients with moderate-to-severe atopic dermatitis (AD) not adequately controlled with systemic therapies, including biologics, or when the use of such treatments is inadvisable.1,2 In September 2021, the Food and Drug Administration issued a boxed warning for a ll JAK inhibitors regarding the increased risk of serious infections, heart attack, stroke, cancer, blood clots, and death.
Source: Journal of the American Academy of Dermatology - August 19, 2023 Category: Dermatology Authors: J. Mark Jackson, Amanda Althoff, Lawrence Rasouliyan, Stacey Long, Carla L. Zema Tags: Research letter Source Type: research
Major adverse cardiovascular events in patients treated with oral Janus kinase inhibitors for atopic dermatitis: a systematic review and meta-analysis
CONCLUSION: Our review highlighted rare cases of MACE among JAK inhibitors users for AD. Janus kinase inhibitors may have little to no effect on the occurrence of MACEs in patients with AD compared to comparators but the evidence is very uncertain. Real-life, long-term, population-level safety studies are needed.PMID:37410552 | DOI:10.1093/bjd/ljad229
Source: The British Journal of Dermatology - July 6, 2023 Category: Dermatology Authors: C écile Ertus Lucie-Marie Scailteux Alain Lescoat Pauline Berthe Vincent Auffret Alain Dupuy Emmanuel Oger Catherine Droitcourt Source Type: research
Climate Change, Skin Health, and Dermatologic Disease: A Guide for the Dermatologist
AbstractClimate change has a pervasive impact on health and is of clinical relevance to every organ system. Climate change-related factors impact the skin ’s capacity to maintain homeostasis, leading to a variety of cutaneous diseases. Stratospheric ozone depletion has led to increased risk of melanoma and keratinocyte carcinomas due to ultraviolet radiation exposure. Atopic dermatitis, psoriasis, pemphigus, acne vulgaris, melasma, and photoaging ar e all associated with rising levels of air pollution. Elevated temperatures due to global warming induce disruption of the skin microbiome, thereby impacting atopic dermatiti...
Source: American Journal of Clinical Dermatology - June 20, 2023 Category: Dermatology Source Type: research
469 Evidence of a causal relationship between stroke and psoriasis
Comorbid cardiovascular disease (including coronary artery disease [CAD] and stroke) is a major source of morbidity and mortality in people with psoriasis. A recent Mendelian randomization (MR) study has provided supportive evidence that lifetime risk of CAD is causally implicated in psoriasis development, independent of adiposity (Patricket al Nat Commun. 2022). However, it is currently unclear whether lifetime risk of stroke influences psoriasis risk. A two-sample MR approach was undertaken to evaluate the putative causal effect of stroke on psoriasis risk.
Source: Journal of Investigative Dermatology - April 17, 2023 Category: Dermatology Authors: R. Ramessur, J. Saklatvala, J. Barker, N. Dand, M. Simpson, C. Smith Source Type: research
532 Shingles and post-herpetic neuralgia (PHN) in post-stroke patients: Real-world evidence
Shingles, known as zoster or herpes zoster, is a neurotropic viral disease featured with painful dermatomal skin eruptions, which leads to a notorious complication, post-herpetic neuralgia (PHN). PHN are usually refractory to treatment and disturbs patients' life. Among the world, stroke is a main cause of morbidity and mortality. Since patients are prone to get infectious diseases during acute phase following stroke, this study is aimed to investigate whether stroke increases the risk of shingles and it's terrible complication, PHN.
Source: Journal of Investigative Dermatology - April 17, 2023 Category: Dermatology Authors: C. Wu, Y. Lu Source Type: research
Lipoedema: detailed left atrial volumetric and strain analysis by three-dimensional speckle-tracking echocardiography from the MAGYAR-Path Study
CONCLUSIONS: Lipoedema is associated with increased LA volumes and changes in LA functional properties. The use of MCS further increases some of the LA volumetric parameters.PMID:35950131 | PMC:PMC9326933 | DOI:10.5114/ada.2022.117536
Source: Advances in Dermatology and Allergology - August 11, 2022 Category: Dermatology Authors: Attila Nemes Árpád Kormányos P éter Domsik Anita Kalapos N ándor Gyenes Lajos Kem ény Gy őző Szolnoky Source Type: research
