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Comprehensive evaluation of the mechanism of Gastrodia elata Blume in ameliorating cerebral ischemia –reperfusion injury based on integrating fecal metabonomics and 16S rDNA sequencing
Gastrodia elata Blume was used to treat stroke and headaches caused by “Feng” for thousands of years. The present study has shown a significant effect of G. elata Blume in improving cerebral ischemia–reperfusion injury (CIRI). However, the mechanism of G. elata Blume in improving CIRI by regulating the intestinal flora has not been reported until now. This research aimed to comprehensively evaluate the mechanism of G. elata Blume in CIRI based on fecal metabolomics and 16S rDNA sequencing. The rat model with CIRI was created based on the Zea Longa method. Enzyme-linked immunosorbent assay (ELISA) was used to monitor ...
Source: Frontiers in cellular and infection microbiology - October 27, 2022 Category: Microbiology Source Type: research

Gut Dysbiosis Is Associated With the Severity of Cryptogenic Stroke and Enhanced Systemic Inflammatory Response
In conclusion, gut dysbiosis in CS patients was associated with the severity of CS and the systemic inflammation. Maintaining the intestinal homeostasis may be a potential strategy for the treatment of CS.
Source: Frontiers in Immunology - May 6, 2022 Category: Allergy & Immunology Source Type: research

Pentraxin 3 in Cardiovascular Disease
Giuseppe Ristagno1*, Francesca Fumagalli1, Barbara Bottazzi2, Alberto Mantovani2,3,4, Davide Olivari1, Deborah Novelli1 and Roberto Latini1 1Department of Cardiovascular Research, Mario Negri Institute for Pharmacological Research IRCCS, Milan, Italy 2Humanitas Clinical and Research Center-IRCCS, Milan, Italy 3Humanitas University, Milan, Italy 4The William Harvey Research Institute, Queen Mary University of London, London, United Kingdom The long pentraxin PTX3 is a member of the pentraxin family produced locally by stromal and myeloid cells in response to proinflammatory signals and microbial moieties. The p...
Source: Frontiers in Immunology - April 16, 2019 Category: Allergy & Immunology Source Type: research

A Comparison of Three Different Bioinformatics Analyses of the 16S –23S rRNA Encoding Region for Bacterial Identification
Conclusion The higher resolution at the species level identification provided by 16S–23S rRNA encoding region NGS makes its use in routine diagnostic microbiology potentially attractive. Particularly, data analysis is one of the most important steps of a diagnostic workflow, which requires an optimal pipeline for the interpretation of the sequencing data in a short time. This study demonstrates that de novo assembly and subsequent BLASTN analysis using an in-house developed database compared to OTU clustering and mapping approaches is the most accurate and fastest approach for identification of bacterial pathogens....
Source: Frontiers in Microbiology - April 15, 2019 Category: Microbiology Source Type: research

Isolation of Antimicrobial Compounds From Cnestis ferruginea Vahl ex. DC (Connaraceae) Leaves Through Bioassay-Guided Fractionation
Conclusion In conclusion, aqueous extracts of C. ferruginea leaves showed antimicrobial activity due to the presence of hydroquinone and caffeic acid methyl ester. This supports its traditional use for infections and confirmed that the active molecules are water-soluble. Author Contributions KK, SP, LVP, and WL conceived and designed the experiments. SP, KK, M-RY, and J-GL performed the experiments. SP, LVP, WL, M-RY, J-GL, and Z-HJ analyzed the data. WL and Z-HJ contributed reagents, materials, and analysis tools. KK, SP, WL, M-RY, Z-HJ, and LVP contributed to the writing of the manuscript. All authors contributed to m...
Source: Frontiers in Microbiology - April 10, 2019 Category: Microbiology Source Type: research

Time-series Analysis of Heat Waves and Emergency Department Visits in Atlanta, 1993 to 2012
Conclusions: Heat waves can confer additional risks of ED visits beyond those of daily air temperature, even in a region with high air-conditioning prevalence. https://doi.org/10.1289/EHP44 Received: 29 February 2016 Revised: 13 October 2016 Accepted: 24 October 2016 Published: 31 May 2017 Address correspondence to H.H. Chang, Department of Biostatistics and Bioinformatics, Emory University, 1518 Clifton Rd. NE, Atlanta, Georgia 30322. Telephone: (404) 712-4627; E-mail: howard.chang@emory.edu Supplemental Material is available online (https://doi.org/10.1289/EHP44). The authors declare they have no actual ...
Source: EHP Research - May 31, 2017 Category: Environmental Health Authors: Terrie Young Tags: Research Source Type: research

Traditional uses of under-utilized tree species in sub tropical rainfed areas of Kathua, Jammu & Kashmir
Title: Traditional uses of under-utilized tree species in sub tropical rainfed areas of Kathua, Jammu& Kashmir Authors: Slathia, PS; Paul, Narinder; Gupta, SK; Sharma, BC; Kumar, Rakesh; Kher, SK Abstract: Present investigation was carried out in three blocks; Hiranagar, Dinga Amb and Marheenof Kathuadistrict of Jammu region of Jammu and Kashmir located in the sub-tropical zone to identify and document the under-utilized forest tree species and their multiple traditional uses. Study revealed that people in the study area make multiple traditional uses of eight tree species which are ordinarily considered under-utilized, ...
Source: Indian Journal of Traditional Knowledge - December 7, 2016 Category: Science Source Type: research