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Less Sodium, More Potassium, or Both: Population-wide Strategies to Prevent Hypertension
Am J Physiol Renal Physiol. 2023 Jun 1. doi: 10.1152/ajprenal.00007.2023. Online ahead of print.ABSTRACTHypertension is among the most prevalent medical conditions globally and a major contributor to chronic kidney disease, cardiovascular disease, and death. Prevention through non-pharmacologic, population-level interventions is critically needed to halt this worldwide epidemic. However, there are ongoing debates as to where public policy efforts should focus. Recently the Salt Substitute and Stroke Study demonstrated the efficacy of substituting table salt with potassium salt to reduce the risk of stroke, major cardiovasc...
Source: American Journal of Physiology. Renal Physiology - June 1, 2023 Category: Physiology Authors: Voravech Nissaisorakarn George Ormseth William Earle Martha Catalina Morales-Alvarez Swapnil Hiremath Stephen P Juraschek Source Type: research

Obesity and kidney transplantation
Curr Opin Organ Transplant. 2023 Feb 1. doi: 10.1097/MOT.0000000000001050. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Obesity has reached epidemic proportions in the United States. It is a risk factor for developing, among others, heart disease, stroke, type 2 diabetes, and chronic kidney disease (CKD), and thus a major public health concern and driver of healthcare costs. Although the prevalence of obesity in the CKD/end-stage kidney disease population is increasing, many obese patients are excluded from the benefit of kidney transplant based on their BMI alone. For this reason, we sought to review the experience th...
Source: Current Opinion in Organ Transplantation - February 8, 2023 Category: Transplant Surgery Authors: Jae-Hyung Chang Vladimir Mushailov Sumit Mohan Source Type: research

There is urgent need to treat atherosclerotic cardiovascular disease risk earlier, more intensively, and with greater precision: A review of current practice and recommendations for improved effectiveness
Am J Prev Cardiol. 2022 Aug 6;12:100371. doi: 10.1016/j.ajpc.2022.100371. eCollection 2022 Dec.ABSTRACTAtherosclerotic cardiovascular disease (ASCVD) is epidemic throughout the world and is etiologic for such acute cardiovascular events as myocardial infarction, ischemic stroke, unstable angina, and death. ASCVD also impacts risk for dementia, chronic kidney disease peripheral arterial disease and mobility, impaired sexual response, and a host of other visceral impairments that adversely impact the quality and rate of progression of aging. The relationship between low-density lipoprotein cholesterol (LDL-C) and risk for AS...
Source: Atherosclerosis - September 20, 2022 Category: Cardiology Authors: Michael E Makover Michael D Shapiro Peter P Toth Source Type: research

The increase of core temperature affected the progression of kidney injury by repeated heat stress exposure.
CONCLUSIONS: These studies suggest that kidney injury in heat stress is markedly worsened by increasing core temperature. The studies are consistent with the hypothesis that clinical and subclinical heat stroke may play a role in Mesoamerican Nephropathy. PMID: 31390229 [PubMed - as supplied by publisher]
Source: American Journal of Physiology. Renal Physiology - August 6, 2019 Category: Physiology Authors: Sato Y, Roncal-Jimenez CA, Andres-Hernando A, Jensen T, Tolan DR, Sanchez-Lozada LG, Newman LS, Butler-Dawson J, Sorensen C, Glaser J, Miyazaki M, Diaz HF, Ishimoto T, Kosugi T, Maruyama S, Garcia GE, Lanaspa MA, Johnson RJ Tags: Am J Physiol Renal Physiol Source Type: research

IJERPH, Vol. 16, Pages 2734: Glyphosate ’s Synergistic Toxicity in Combination with Other Factors as a Cause of Chronic Kidney Disease of Unknown Origin
IJERPH, Vol. 16, Pages 2734: Glyphosate’s Synergistic Toxicity in Combination with Other Factors as a Cause of Chronic Kidney Disease of Unknown Origin International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16152734 Authors: Sarath Gunatilake Stephanie Seneff Laura Orlando Chronic kidney disease of unknown etiology (CKDu) is a global epidemic. Sri Lanka has experienced a doubling of the disease every 4 or 5 years since it was first identified in the North Central province in the mid-1990s. The disease primarily affects people in agricultural regions who are missing the commonly k...
Source: International Journal of Environmental Research and Public Health - July 30, 2019 Category: Environmental Health Authors: Sarath Gunatilake Stephanie Seneff Laura Orlando Tags: Review Source Type: research

The Need to Evaluate Net Clinical Effect of Stroke Prevention Therapy in Patients with End Stage Renal Disease and Atrial Fibrillation.
Abstract Chronic kidney disease (CKD) and atrial fibrillation (AF) are both emerging health epidemics worldwide. Atrial fibrillation is the most common heart rhythm disorder and the burden of this dysrhythmia is expected to increase as the population ages(1). Similarly, chronic kidney disease is a disease of the elderly that is estimated to affect 40-50% of US adults over 65 in the near future(2,3). This is likely due to manifestations of common risk factors and pathology that eventually lead to high cardiovascular and stroke risk in patients with CKD, especially patients with AF and CKD(4,5). Unfortunately, the f...
Source: Circulation - December 17, 2015 Category: Cardiology Authors: Patel MR, Piccini JP Tags: Circulation Source Type: research

Experiential or behavioral processes: Which one is prominent in physical activity? Examining the processes of change one year after an intervention of therapeutic education among adults with obesity
Obesity is recognized as a growing epidemic with the worldwide Body Mass Index (BMI) increasing by 0.5kg/m2 per decade since 1980 [1]. It is associated with increased total mortality and increased risks of disease or death from diabetes, ischemic heart disease and ischemic stroke, cancers, chronic kidney disease, and osteoarthritis [2]. Beneficial effects of physical activity (PA) on body weight and global health have now been clearly proven and besides diet and behavior therapy, PA is considered as a cornerstone of weight management for overweight/obese adults [3–5].
Source: Patient Education and Counseling - August 13, 2014 Category: Global & Universal Authors: Ahmed Jérôme Romain, Vincent Attalin, Ariane Sultan, Catherine Boegner, Christophe Gernigon, Antoine Avignon Source Type: research

Experiential or behavioral processes: Which one is prominent in physical activity? Examining the processes of change 1 year after an intervention of therapeutic education among adults with obesity
Obesity is recognized as a growing epidemic with the worldwide body mass index (BMI) increasing by 0.5kg/m2 per decade since 1980 [1]. It is associated with increased total mortality and increased risks of disease or death from diabetes, ischemic heart disease and ischemic stroke, cancers, chronic kidney disease, and osteoarthritis [2]. Beneficial effects of physical activity (PA) on body weight and global health have now been clearly proven and besides diet and behavior therapy, PA is considered as a cornerstone of weight management for overweight/obese adults [3–5].
Source: Patient Education and Counseling - August 13, 2014 Category: Global & Universal Authors: A.J. Romain, V. Attalin, A. Sultan, C. Boegner, C. Gernigon, A. Avignon Tags: Intervention Source Type: research

Obesity and heart failure as a mediator of the cerebrorenal interaction.
Abstract The obesity epidemic is contributing substantially to the burden of cardiovascular disease including heart disease and congestive heart failure, in the United States and the rest of the world. Overnutrition as a driver of obesity, promotes alterations in fatty acid, lipid, and glucose metabolism that influence myocardial function and progression of heart failure from diastolic to systolic failure. The association of progressive heart failure and progressive chronic kidney disease is well documented and often referred to as the cardiorenal syndrome, as well as a prognosticator for cerebrovascular disease (...
Source: Contributions to Nephrology - May 26, 2013 Category: Urology & Nephrology Authors: Jindal A, Whaley-Connell A, Sowers JR Tags: Contrib Nephrol Source Type: research

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