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Source: The Lancet Neurology
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Total 249 results found since Jan 2013.
Safety and efficacy of GABAA α5 antagonist S44819 in patients with ischaemic stroke: a multicentre, double-blind, randomised, placebo-controlled trial
Publication date: March 2020Source: The Lancet Neurology, Volume 19, Issue 3Author(s): Hugues Chabriat, Claudio L Bassetti, Ute Marx, Marie-Laure Audoli-Inthavong, Aurore Sors, Estelle Lambert, Marine Wattez, Dirk M Hermann, Katharina ALTHAUS, Sergi AMARO, Hee-Joon BAE, Zbigniew BAK, Leonardo BARBARINI, Pietro BASSI, Rodrigo BAZAN, Daniel BERECZKI, Tomasz BERKOWICZ, Joerg BERROUSCHOT, Dylan BLACQUIERE, Waldemar BROLASummaryBackgroundS44819, a selective GABAA α5 receptor antagonist, reduces tonic post-ischaemic inhibition of the peri-infarct cortex. S44819 improved stroke recovery in rodents and increased cortical excitabi...
Source: The Lancet Neurology - February 19, 2020 Category: Neurology Source Type: research
Issues important to the design of stroke recovery trials
Publication date: March 2020Source: The Lancet Neurology, Volume 19, Issue 3Author(s): Steven C Cramer
Source: The Lancet Neurology - February 19, 2020 Category: Neurology Source Type: research
Advances and challenges in stroke rehabilitation
Publication date: Available online 28 January 2020Source: The Lancet NeurologyAuthor(s): Cathy M Stinear, Catherine E Lang, Steven Zeiler, Winston D ByblowSummaryStroke remains a leading cause of adult disability and the demand for stroke rehabilitation services is growing. Substantial advances are yet to be made in stroke rehabilitation practice to meet this demand and improve patient outcomes relative to current care. Several large intervention trials targeting motor recovery report that participants' motor performance improved, but to a similar extent for both the intervention and control groups in most trials. These ne...
Source: The Lancet Neurology - January 30, 2020 Category: Neurology Source Type: research
Stroke research in 2019: towards optimising treatment and prevention
Publication date: January 2020Source: The Lancet Neurology, Volume 19, Issue 1Author(s): Simiao Wu, Yajun Cheng, Bo Wu, Ming Liu
Source: The Lancet Neurology - December 12, 2019 Category: Neurology Source Type: research
Endovascular treatment versus standard medical treatment for vertebrobasilar artery occlusion (BEST): an open-label, randomised controlled trial
In this study, we aimed to investigate the safety and efficacy of endovascular treatment of acute strokes due to vertebrobasilar artery occlusion.MethodsWe did a multicentre, randomised, open-label trial, with blinded outcome assessment of thrombectomy in patients presenting within 8 h of vertebrobasilar occlusion at 28 centres in China. Patients were randomly assigned (1:1) to endovascular therapy plus standard medical therapy (intervention group) or standard medical therapy alone (control group). The randomisation sequence was computer-generated and stratified by participating centres. Allocation concealment was implemen...
Source: The Lancet Neurology - December 10, 2019 Category: Neurology Source Type: research
The gut microbiome in neurological disorders
Publication date: Available online 18 November 2019Source: The Lancet NeurologyAuthor(s): John F Cryan, Kenneth J O'Riordan, Kiran Sandhu, Veronica Peterson, Timothy G DinanSummaryResearch into the role of the gut microbiome in modulating brain function has rapidly increased over the past 10 years, albeit chiefly in animal models. Increasing clinical and preclinical evidence implicates the microbiome as a possible key susceptibility factor for neurological disorders, including Alzheimer's disease, autism spectrum disorder, multiple sclerosis, Parkinson's disease, and stroke. Cross-sectional clinical studies are bolstering ...
Source: The Lancet Neurology - November 19, 2019 Category: Neurology Source Type: research
Support programme for secondary prevention of stroke: inspiration to continue?
Publication date: Available online 7 November 2019Source: The Lancet NeurologyAuthor(s): Linxin Li
Source: The Lancet Neurology - November 8, 2019 Category: Neurology Source Type: research
A support programme for secondary prevention in patients with transient ischaemic attack and minor stroke (INSPiRE-TMS): an open-label, randomised controlled trial
Publication date: Available online 7 November 2019Source: The Lancet NeurologyAuthor(s): Michael Ahmadi, Inga Laumeier, Thomas Ihl, Maureen Steinicke, Caroline Ferse, Matthias Endres, Armin Grau, Sidsel Hastrup, Holger Poppert, Frederick Palm, Martin Schoene, Christian L Seifert, Farid I Kandil, Joachim E Weber, Paul von Weitzel-Mudersbach, Martin L J Wimmer, Ale Algra, Pierre Amarenco, Jacoba P Greving, Otto BusseSummaryBackgroundPatients with recent stroke or transient ischaemic attack are at high risk for a further vascular event, possibly leading to permanent disability or death. Although evidence-based treatments for ...
Source: The Lancet Neurology - November 8, 2019 Category: Neurology Source Type: research
Availability of stroke units in Colombia
Publication date: November 2019Source: The Lancet Neurology, Volume 18, Issue 11Author(s): Hernán Bayona-Ortiz, Juan Nicolás Useche, Nicolás Yanez, Sofia Catalina Velasco
Source: The Lancet Neurology - October 11, 2019 Category: Neurology Source Type: research
Global prevention of stroke: focus on the individual?
Publication date: October 2019Source: The Lancet Neurology, Volume 18, Issue 10Author(s): The Lancet Neurology
Source: The Lancet Neurology - September 14, 2019 Category: Neurology Source Type: research
Association between plasma GFAP concentrations and MRI abnormalities in patients with CT-negative traumatic brain injury in the TRACK-TBI cohort: a prospective multicentre study
This study is registered with ClinicalTrials.gov, number NCT02119182.FindingsBetween Feb 26, 2014, and June 15, 2018, we recruited 450 patients with normal head CT scans (of whom 330 had negative MRI scans and 120 had positive MRI scans), 122 orthopaedic trauma controls, and 209 healthy controls. AUC for GFAP in patients with CT-negative and MRI-positive findings versus patients with CT-negative and MRI-negative findings was 0·777 (95% CI 0·726–0·829) over 24 h. Median plasma GFAP concentration was highest in patients with CT-negative and MRI-positive findings (414·4 pg/mL, 25–75th percentile 139·3–813·4), foll...
Source: The Lancet Neurology - August 24, 2019 Category: Neurology Source Type: research
Blood pressure control and clinical outcomes in acute intracerebral haemorrhage: a preplanned pooled analysis of individual participant data
Publication date: September 2019Source: The Lancet Neurology, Volume 18, Issue 9Author(s): Tom J Moullaali, Xia Wang, Reneé H Martin, Virginia B Shipes, Thompson G Robinson, John Chalmers, Jose I Suarez, Adnan I Qureshi, Yuko Y Palesch, Craig S AndersonSummaryBackgroundUncertainty persists over the effects of blood pressure lowering in acute intracerebral haemorrhage. We aimed to combine individual patient-level data from the two largest randomised controlled trials of blood pressure lowering strategies in patients with acute intracerebral haemorrhage to determine the strength of associations between key measures of systo...
Source: The Lancet Neurology - August 8, 2019 Category: Neurology Source Type: research
Self-managed, computerised speech and language therapy for patients with chronic aphasia post-stroke compared with usual care or attention control (Big CACTUS): a multicentre, single-blinded, randomised controlled trial
Publication date: September 2019Source: The Lancet Neurology, Volume 18, Issue 9Author(s): Rebecca Palmer, Munyaradzi Dimairo, Cindy Cooper, Pam Enderby, Marian Brady, Audrey Bowen, Nicholas Latimer, Steven Julious, Elizabeth Cross, Abualbishr Alshreef, Madeleine Harrison, Ellen Bradley, Helen Witts, Tim ChaterSummaryBackgroundPost-stroke aphasia might improve over many years with speech and language therapy; however speech and language therapy is often less readily available beyond a few months after stroke. We assessed self-managed computerised speech and language therapy (CSLT) as a means of providing more therapy than ...
Source: The Lancet Neurology - August 8, 2019 Category: Neurology Source Type: research
Computerised speech and language therapy in post-stroke aphasia
Publication date: September 2019Source: The Lancet Neurology, Volume 18, Issue 9Author(s): Agnes Flöel
Source: The Lancet Neurology - August 8, 2019 Category: Neurology Source Type: research
Long-term antithrombotic therapy and risk of intracranial haemorrhage from cerebral cavernous malformations: a population-based cohort study, systematic review, and meta-analysis
Publication date: Available online 7 August 2019Source: The Lancet NeurologyAuthor(s): Susanna M Zuurbier, Charlotte R Hickman, Christos S Tolias, Leon A Rinkel, Rebecca Leyrer, Kelly D Flemming, David Bervini, Giuseppe Lanzino, Robert J Wityk, Hans-Martin Schneble, Ulrich Sure, Rustam Al-Shahi Salman, Scottish Audit of Intracranial Vascular Malformations Steering CommitteeSummaryBackgroundAntithrombotic (anticoagulant or antiplatelet) therapy is withheld from some patients with cerebral cavernous malformations, because of uncertainty around the safety of these drugs in such patients. We aimed to establish whether antithro...
Source: The Lancet Neurology - August 8, 2019 Category: Neurology Source Type: research
