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Source: The Lancet Neurology
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Total 249 results found since Jan 2013.
Preventing both stroke and dementia
Publication date: June 2016 Source:The Lancet Neurology, Volume 15, Issue 7 Author(s): Vladimir Hachinski, Luciano A Sposato, Moira Kapral
Source: The Lancet Neurology - May 11, 2016 Category: Neurology Source Type: research
Preventing both stroke and dementia – Authors' reply
Publication date: June 2016 Source:The Lancet Neurology, Volume 15, Issue 7 Author(s): Carol Brayne, Yu-Tzu Wu
Source: The Lancet Neurology - May 11, 2016 Category: Neurology Source Type: research
Leonardo's recurrent stroke?
Publication date: June 2016 Source:The Lancet Neurology, Volume 15, Issue 7 Author(s): Coralli Alessia, Perciaccante Antonio
Source: The Lancet Neurology - May 11, 2016 Category: Neurology Source Type: research
Effect of baseline Alberta Stroke Program Early CT Score on safety and efficacy of intra-arterial treatment: a subgroup analysis of a randomised phase 3 trial (MR CLEAN)
We examined the effect of the baseline Alberta Stroke Program Early CT Score (ASPECTS) on the safety and efficacy of intra-arterial treatment in a subgroup analysis of the Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands (MR CLEAN). Methods MR CLEAN was a randomised, controlled, open-label, phase 3 trial of intra-arterial treatment in patients (aged ≥18 years from the Netherlands) with proximal arterial occlusion of the anterior circulation, given intra-arterial treatment within 6 h of stroke onset. The primary outcome was 90 day modified Rankin Scale (mRS) sco...
Source: The Lancet Neurology - May 11, 2016 Category: Neurology Source Type: research
Neuroprotection in acute stroke: targeting excitotoxicity, oxidative and nitrosative stress, and inflammation
Publication date: Available online 11 May 2016 Source:The Lancet Neurology Author(s): Ángel Chamorro, Ulrich Dirnagl, Xabier Urra, Anna M Planas Treatments for acute ischaemic stroke continue to evolve after the superior value of endovascular thrombectomy was confirmed over systemic thrombolysis. Unfortunately, numerous neuroprotective drugs have failed to show benefit in the treatment of acute ischaemic stroke, making the search for new treatments imperative. Increased awareness of the relevance of rigorous preclinical testing, and appropriate selection of study participants, might overcome the barriers to progress...
Source: The Lancet Neurology - May 11, 2016 Category: Neurology Source Type: research
Fresh frozen plasma versus prothrombin complex concentrate in patients with intracranial haemorrhage related to vitamin K antagonists (INCH): a randomised trial
Publication date: May 2016 Source:The Lancet Neurology, Volume 15, Issue 6 Author(s): Thorsten Steiner, Sven Poli, Martin Griebe, Johannes Hüsing, Jacek Hajda, Anja Freiberger, Martin Bendszus, Julian Bösel, Hanne Christensen, Christian Dohmen, Michael Hennerici, Jennifer Kollmer, Henning Stetefeld, Katja E Wartenberg, Christian Weimar, Werner Hacke, Roland Veltkamp Background Haematoma expansion is a major cause of mortality in intracranial haemorrhage related to vitamin K antagonists (VKA-ICH). Normalisation of the international normalised ratio (INR) is recommended, but optimum haemostatic managemen...
Source: The Lancet Neurology - April 19, 2016 Category: Neurology Source Type: research
Identification of additional risk loci for stroke and small vessel disease: a meta-analysis of genome-wide association studies
Publication date: Available online 7 April 2016 Source:The Lancet Neurology Author(s): Neurology Working Group of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) ConsortiumStroke Genetics Network (SiGN)International Stroke Genetics Consortium (ISGC) Background Genetic determinants of stroke, the leading neurological cause of death and disability, are poorly understood and have seldom been explored in the general population. Our aim was to identify additional loci for stroke by doing a meta-analysis of genome-wide association studies. Methods For the discovery sample, we did a genome-wide analys...
Source: The Lancet Neurology - April 7, 2016 Category: Neurology Source Type: research
A stroke of insight from genetics
Publication date: Available online 7 April 2016 Source:The Lancet Neurology Author(s): Peter M Visscher, Jan H Veldink
Source: The Lancet Neurology - April 7, 2016 Category: Neurology Source Type: research
South Africa: stroke units out of the blue
Publication date: April 2016 Source:The Lancet Neurology, Volume 15, Issue 4 Author(s): Adrian Burton
Source: The Lancet Neurology - March 9, 2016 Category: Neurology Source Type: research
Human genetics shines a light on ischaemic stroke
Publication date: Available online 19 December 2015 Source:The Lancet Neurology Author(s): Benjamin F Voight, Daniel J Rader
Source: The Lancet Neurology - December 19, 2015 Category: Neurology Source Type: research
Loci associated with ischaemic stroke and its subtypes (SiGN): a genome-wide association study
Publication date: Available online 19 December 2015 Source:The Lancet Neurology Author(s): NINDS Stroke Genetics Network (SiGN)International Stroke Genetics Consortium (ISGC) Background The discovery of disease-associated loci through genome-wide association studies (GWAS) is the leading genetic approach to the identification of novel biological pathways underlying diseases in humans. Until recently, GWAS in ischaemic stroke have been limited by small sample sizes and have yielded few loci associated with ischaemic stroke. We did a large-scale GWAS to identify additional susceptibility genes for stroke and its subtypes. ...
Source: The Lancet Neurology - December 19, 2015 Category: Neurology Source Type: research
Stroke in 2015: the year of endovascular treatment
Publication date: January 2016 Source:The Lancet Neurology, Volume 15, Issue 1 Author(s): Keith W Muir
Source: The Lancet Neurology - December 8, 2015 Category: Neurology Source Type: research
Clinical course of untreated cerebral cavernous malformations: a meta-analysis of individual patient data
Publication date: Available online 2 December 2015 Source:The Lancet Neurology Author(s): Margaret A Horne, Kelly D Flemming, I-Chang Su, Christian Stapf, Jin Pyeong Jeon, Da Li, Susanne S Maxwell, Philip White, Teresa J Christianson, Ronit Agid, Won-Sang Cho, Chang Wan Oh, Zhen Wu, Jun-Ting Zhang, Jeong Eun Kim, Karel ter Brugge, Robert Willinsky, Robert D Brown, Gordon D Murray, Rustam Al-Shahi Salman Background Cerebral cavernous malformations (CCMs) can cause symptomatic intracranial haemorrhage (ICH), but the estimated risks are imprecise and predictors remain uncertain. We aimed to obtain precis...
Source: The Lancet Neurology - December 3, 2015 Category: Neurology Source Type: research
Development of epilepsy after ischaemic stroke
Publication date: Available online 17 November 2015 Source:The Lancet Neurology Author(s): Asla Pitkänen, Reina Roivainen, Katarzyna Lukasiuk For about 30% of patients with epilepsy the cause is unknown. Even in patients with a known risk factor for epilepsy, such as ischaemic stroke, only a subpopulation of patients develops epilepsy. Factors that contribute to the risk for epileptogenesis in a given individual generally remain unknown. Studies in the past decade on epilepsy in patients with ischaemic stroke suggest that, in addition to the primary ischaemic injury, existing difficult-to-detect microscale changes in...
Source: The Lancet Neurology - November 17, 2015 Category: Neurology Source Type: research
Cranial functional (psychogenic) movement disorders
Publication date: December 2015 Source:The Lancet Neurology, Volume 14, Issue 12 Author(s): Diego Kaski, Adolfo M Bronstein, Mark J Edwards, Jon Stone Functional (psychogenic) neurological symptoms are frequently encountered in neurological practice. Cranial movement disorders—affecting the eyes, face, jaw, tongue, or palate—are an under-recognised feature of patients with functional symptoms. They can present in isolation or in the context of other functional symptoms; in particular, for functional eye movements, positive clinical signs such as convergence spasms can be triggered by the clinical examination. Alt...
Source: The Lancet Neurology - November 11, 2015 Category: Neurology Source Type: research
