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Source: The Lancet Neurology
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Total 249 results found since Jan 2013.
Sex differences in the evaluation and treatment of acute ischaemic stroke
Publication date: July 2018Source: The Lancet Neurology, Volume 17, Issue 7Author(s): Cheryl Bushnell, Virginia J Howard, Lynda Lisabeth, Valeria Caso, Seana Gall, Dawn Kleindorfer, Seemant Chaturvedi, Tracy E Madsen, Stacie L Demel, Seung-Jae Lee, Mathew ReevesSummaryWith the greater availability of treatments for acute ischaemic stroke, including advances in endovascular therapy, personalised assessment of patients before treatment is more important than ever. Women have a higher lifetime risk of stroke; therefore, reducing potential sex differences in the acute stroke setting is crucial for the provision of equitable an...
Source: The Lancet Neurology - July 5, 2018 Category: Neurology Source Type: research
Prevalence of patent foramen ovale in cryptogenic transient ischaemic attack and non-disabling stroke at older ages: a population-based study, systematic review, and meta-analysis
Publication date: July 2018Source: The Lancet Neurology, Volume 17, Issue 7Author(s): Sara Mazzucco, Linxin Li, Lucy Binney, Peter M Rothwell, Oxford Vascular Study Phenotyped CohortSummaryBackgroundPercutaneous closure of patent foramen ovale (PFO) has been shown to be superior to medical treatment alone for prevention of recurrent stroke after cryptogenic transient ischaemic attack or non-disabling stroke in patients aged 60 years or younger. The justification for trials in older patients with transient ischaemic attack or stroke depends on whether PFO is shown to be associated with cryptogenic events at older ages, for ...
Source: The Lancet Neurology - July 5, 2018 Category: Neurology Source Type: research
Restenosis and risk of stroke after stenting or endarterectomy for symptomatic carotid stenosis in the International Carotid Stenting Study (ICSS): secondary analysis of a randomised trial
This report presents a secondary analysis, and follow-up is complete.FindingsBetween May, 2001, and October, 2008, 1713 patients were enrolled and randomly allocated treatment (855 were assigned stenting and 858 endarterectomy), of whom 1530 individuals were followed up with ultrasound (737 assigned stenting and 793 endarterectomy) for a median of 4·0 years (IQR 2·3–5·0). At least moderate restenosis (≥50%) occurred in 274 patients after stenting (cumulative 5-year risk 40·7%) and in 217 after endarterectomy (29·6%; unadjusted hazard ratio [HR] 1·43, 95% CI 1·21–1·72; p<0·0001). Patients with at least mo...
Source: The Lancet Neurology - July 5, 2018 Category: Neurology Source Type: research
Patent foramen ovale in older patients with cryptogenic stroke or transient ischaemic attack
Publication date: July 2018Source: The Lancet Neurology, Volume 17, Issue 7Author(s): David Thaler
Source: The Lancet Neurology - July 5, 2018 Category: Neurology Source Type: research
A new life after stroke
Publication date: Available online 26 June 2018Source: The Lancet NeurologyAuthor(s): Jules Morgan
Source: The Lancet Neurology - July 5, 2018 Category: Neurology Source Type: research
Clinical innovation in stroke: getting the simple things right
Publication date: June 2018Source: The Lancet Neurology, Volume 17, Issue 6Author(s): Peter M Rothwell
Source: The Lancet Neurology - July 5, 2018 Category: Neurology Source Type: research
Balancing risks versus benefits of anticoagulants in stroke prevention
Publication date: June 2018Source: The Lancet Neurology, Volume 17, Issue 6Author(s): Charlotte Cordonnier
Source: The Lancet Neurology - July 5, 2018 Category: Neurology Source Type: research
Strong alliances to improve stroke care
Publication date: June 2018Source: The Lancet Neurology, Volume 17, Issue 6Author(s): The Lancet Neurology
Source: The Lancet Neurology - July 5, 2018 Category: Neurology Source Type: research
Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study
Publication date: June 2018Source: The Lancet Neurology, Volume 17, Issue 6Author(s): Cyril Pottier, Xiaolai Zhou, Ralph B Perkerson, Matt Baker, Gregory D Jenkins, Daniel J Serie, Roberta Ghidoni, Luisa Benussi, Giuliano Binetti, Adolfo López de Munain, Miren Zulaica, Fermin Moreno, Isabelle Le Ber, Florence Pasquier, Didier Hannequin, Raquel Sánchez-Valle, Anna Antonell, Albert Lladó, Tammee M Parsons, NiCole A FinchSummaryBackgroundLoss-of-function mutations in GRN cause frontotemporal lobar degeneration (FTLD). Patients with GRN mutations present with a uniform subtype of TAR DNA-binding protein 43 (TDP-43) patholog...
Source: The Lancet Neurology - July 5, 2018 Category: Neurology Source Type: research
Cerebral microbleeds and intracranial haemorrhage risk in patients anticoagulated for atrial fibrillation after acute ischaemic stroke or transient ischaemic attack (CROMIS-2): a multicentre observational cohort study
This study is registered with ClinicalTrials.gov, number NCT02513316.FindingsBetween Aug 4, 2011, and July 31, 2015, we recruited 1490 participants of whom follow-up data were available for 1447 (97%), over a mean period of 850 days (SD 373; 3366 patient-years). The symptomatic intracranial haemorrhage rate in patients with cerebral microbleeds was 9·8 per 1000 patient-years (95% CI 4·0–20·3) compared with 2·6 per 1000 patient-years (95% CI 1·1–5·4) in those without cerebral microbleeds (adjusted hazard ratio 3·67, 95% CI 1·27–10·60). Compared with the HAS-BLED score alone (C-index 0·41, 95% CI 0·29–0·5...
Source: The Lancet Neurology - July 5, 2018 Category: Neurology Source Type: research
Prevention of cardiovascular events in Asian patients with ischaemic stroke at high risk of cerebral haemorrhage (PICASSO): a multicentre, randomised controlled trial
Publication date: June 2018Source: The Lancet Neurology, Volume 17, Issue 6Author(s): Bum Joon Kim, Eun-Jae Lee, Sun U Kwon, Jong-Ho Park, Yong-Jae Kim, Keun-Sik Hong, Lawrence K S Wong, Sungwook Yu, Yang-Ha Hwang, Ji Sung Lee, Juneyoung Lee, Joung-Ho Rha, Sung Hyuk Heo, Sung Hwan Ahn, Woo-Keun Seo, Jong-Moo Park, Ju-Hun Lee, Jee-Hyun Kwon, Sung-Il Sohn, Jin-Man JungSummaryBackgroundThe optimal treatment for patients with ischaemic stroke with a high risk of cerebral haemorrhage is unclear. We assessed the efficacy and safety of cilostazol versus aspirin, with and without probucol, in these patients.MethodsIn this randomis...
Source: The Lancet Neurology - July 5, 2018 Category: Neurology Source Type: research
A new life after stroke
Publication date: Available online 26 June 2018 Source:The Lancet Neurology Author(s): Jules Morgan
Source: The Lancet Neurology - June 27, 2018 Category: Neurology Source Type: research
Sex differences in the evaluation and treatment of acute ischaemic stroke
Publication date: July 2018 Source:The Lancet Neurology, Volume 17, Issue 7 Author(s): Cheryl Bushnell, Virginia J Howard, Lynda Lisabeth, Valeria Caso, Seana Gall, Dawn Kleindorfer, Seemant Chaturvedi, Tracy E Madsen, Stacie L Demel, Seung-Jae Lee, Mathew Reeves With the greater availability of treatments for acute ischaemic stroke, including advances in endovascular therapy, personalised assessment of patients before treatment is more important than ever. Women have a higher lifetime risk of stroke; therefore, reducing potential sex differences in the acute stroke setting is crucial for the provision of equitable and fa...
Source: The Lancet Neurology - June 16, 2018 Category: Neurology Source Type: research
Prevalence of patent foramen ovale in cryptogenic transient ischaemic attack and non-disabling stroke at older ages: a population-based study, systematic review, and meta-analysis
Publication date: Available online 7 June 2018 Source:The Lancet Neurology Author(s): Sara Mazzucco, Linxin Li, Lucy Binney, Peter M Rothwell Background Percutaneous closure of patent foramen ovale (PFO) has been shown to be superior to medical treatment alone for prevention of recurrent stroke after cryptogenic transient ischaemic attack or non-disabling stroke in patients aged 60 years or younger. The justification for trials in older patients with transient ischaemic attack or stroke depends on whether PFO is shown to be associated with cryptogenic events at older ages, for which existing evidence is conflicting, and o...
Source: The Lancet Neurology - June 8, 2018 Category: Neurology Source Type: research
Patent foramen ovale in older patients with cryptogenic stroke or transient ischaemic attack
Publication date: Available online 7 June 2018 Source:The Lancet Neurology Author(s): David Thaler
Source: The Lancet Neurology - June 8, 2018 Category: Neurology Source Type: research
