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Source: The Lancet Neurology
Condition: Stroke
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Total 244 results found since Jan 2013.
Global brain inflammation in stroke
Publication date: Available online 8 July 2019Source: The Lancet NeurologyAuthor(s): Kaibin Shi, De-Cai Tian, Zhi-Guo Li, Andrew F Ducruet, Michael T Lawton, Fu-Dong ShiSummaryStroke, including acute ischaemic stroke and intracerebral haemorrhage, results in neuronal cell death and the release of factors such as damage-associated molecular patterns (DAMPs) that elicit localised inflammation in the injured brain region. Such focal brain inflammation aggravates secondary brain injury by exacerbating blood–brain barrier damage, microvascular failure, brain oedema, oxidative stress, and by directly inducing neuronal cell dea...
Source: The Lancet Neurology - July 10, 2019 Category: Neurology Source Type: research
The pathway towards an effective reduction of stroke burden worldwide: teamwork
Publication date: July 2019Source: The Lancet Neurology, Volume 18, Issue 7Author(s): Gustavo Saposnik, Vladimir Hachinski
Source: The Lancet Neurology - June 13, 2019 Category: Neurology Source Type: research
Stenting for symptomatic vertebral artery stenosis: a preplanned pooled individual patient data analysis
Publication date: Available online 23 May 2019Source: The Lancet NeurologyAuthor(s): Hugh S Markus, Eric L Harshfield, Annette Compter, Wilhelm Kuker, L Jaap Kappelle, Andrew Clifton, H Bart van der Worp, Peter Rothwell, Ale Algra, Neil Baldwin, Marcus Bradley, Stefan Brew, Robert Crossley, Anand Dixit, Hedley Emsley, Ian Ford, Peter Gaines, Anil Gholkhar, Anthony Goddard, Timothy HamptonSummaryBackgroundSymptomatic vertebral artery stenosis is associated with a high risk of recurrent stroke, with higher risks for intracranial than for extracranial stenosis. Vertebral artery stenosis can be treated with stenting with good ...
Source: The Lancet Neurology - May 25, 2019 Category: Neurology Source Type: research
Can cerebral microbleeds predict stroke recurrence?
Publication date: Available online 23 May 2019Source: The Lancet NeurologyAuthor(s): Georgios Tsivgoulis, Aristeidis H Katsanos
Source: The Lancet Neurology - May 23, 2019 Category: Neurology Source Type: research
Cerebral microbleeds and stroke risk after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies
Publication date: Available online 23 May 2019Source: The Lancet NeurologyAuthor(s): Duncan Wilson, Gareth Ambler, Keon-Joo Lee, Jae-Sung Lim, Masayuki Shiozawa, Masatoshi Koga, Linxin Li, Caroline Lovelock, Hugues Chabriat, Michael Hennerici, Yuen Kwun Wong, Henry Ka Fung Mak, Luis Prats-Sánchez, Alejandro Martínez-Domeño, Shigeru Inamura, Kazuhisa Yoshifuji, Ethem Murat Arsava, Solveig Horstmann, Jan Purrucker, Bonnie Yin Ka LamSummaryBackgroundCerebral microbleeds are a neuroimaging biomarker of stroke risk. A crucial clinical question is whether cerebral microbleeds indicate patients with recent ischaemic stroke or ...
Source: The Lancet Neurology - May 23, 2019 Category: Neurology Source Type: research
Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial
Publication date: Available online 22 May 2019Source: The Lancet NeurologyAuthor(s): Rustam Al-Shahi Salman, David P Minks, Dipayan Mitra, Mark A Rodrigues, Priya Bhatnagar, Johann C du Plessis, Yogish Joshi, Martin S Dennis, Gordon D Murray, David E Newby, Peter A G Sandercock, Nikola Sprigg, Jacqueline Stephen, Cathie L M Sudlow, David J Werring, William N Whiteley, Joanna M Wardlaw, Philip M White, Colin Baigent, Daniel LassersonSummaryBackgroundFindings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antipl...
Source: The Lancet Neurology - May 23, 2019 Category: Neurology Source Type: research
Dual antiplatelet therapy using cilostazol for secondary prevention in patients with high-risk ischaemic stroke in Japan: a multicentre, open-label, randomised controlled trial
Publication date: June 2019Source: The Lancet Neurology, Volume 18, Issue 6Author(s): Kazunori Toyoda, Shinichiro Uchiyama, Takenori Yamaguchi, J Donald Easton, Kazumi Kimura, Haruhiko Hoshino, Nobuyuki Sakai, Yasushi Okada, Kortaro Tanaka, Hideki Origasa, Hiroaki Naritomi, Kiyohiro Houkin, Keiji Yamaguchi, Masanori Isobe, Kazuo Minematsu, Shinya Goto, Tatsuya Isomura, Masayasu Matsumoto, Yasuo Terayama, Hidekazu TomimotoSummaryBackgroundAlthough dual antiplatelet therapy with aspirin and clopidogrel reduces early recurrence of ischaemic stroke, with long-term use this type of therapy is no longer effective and the risk of...
Source: The Lancet Neurology - May 22, 2019 Category: Neurology Source Type: research
Safety and efficacy of co-careldopa as an add-on therapy to occupational and physical therapy in patients after stroke (DARS): a randomised, double-blind, placebo-controlled trial
Publication date: June 2019Source: The Lancet Neurology, Volume 18, Issue 6Author(s): Gary A Ford, Bipin B Bhakta, Alastair Cozens, Suzanne Hartley, Ivana Holloway, David Meads, John Pearn, Sharon Ruddock, Catherine M Sackley, Eirini-Christina Saloniki, Gillian Santorelli, Marion F Walker, Amanda J FarrinSummaryBackgroundDopamine is a key modulator of striatal function and learning and might improve motor recovery after stroke. Previous small trials of dopamine agonists after stroke provide equivocal evidence of effectiveness on improving motor recovery. We aimed to assess the safety and efficacy of co-careldopa plus routi...
Source: The Lancet Neurology - May 22, 2019 Category: Neurology Source Type: research
The uncertain role for phosphodiesterase inhibitors in stroke prevention
Publication date: June 2019Source: The Lancet Neurology, Volume 18, Issue 6Author(s): Michael D Hill, Oscar R Benavente
Source: The Lancet Neurology - May 22, 2019 Category: Neurology Source Type: research
Dopamine for motor recovery after stroke: where to from here?
Publication date: June 2019Source: The Lancet Neurology, Volume 18, Issue 6Author(s): Cathy M Stinear
Source: The Lancet Neurology - May 22, 2019 Category: Neurology Source Type: research
Adding stroke to the political agenda in Europe
Publication date: June 2019Source: The Lancet Neurology, Volume 18, Issue 6Author(s): The Lancet Neurology
Source: The Lancet Neurology - May 22, 2019 Category: Neurology Source Type: research
Small vessel disease: mechanisms and clinical implications
Publication date: Available online 13 May 2019Source: The Lancet NeurologyAuthor(s): Joanna M Wardlaw, Colin Smith, Martin DichgansSummarySmall vessel disease is a disorder of cerebral microvessels that causes white matter hyperintensities and several other common abnormalities (eg, recent small subcortical infarcts and lacunes) seen on brain imaging. Despite being a common cause of stroke and vascular dementia, the underlying pathogenesis is poorly understood. Research in humans has identified several manifestations of cerebral microvessel endothelial dysfunction including blood–brain barrier dysfunction, impaired vasod...
Source: The Lancet Neurology - May 14, 2019 Category: Neurology Source Type: research
Priorities to reduce the burden of stroke in Latin American countries
Discussions were focused on the regional and country-specific activities associated with stroke prevention and treatment, including public stroke awareness, prevention strategies, delivery and organisation of care, clinical practice gaps, and unmet needs. The meeting culminated with the adoption of the special Gramado Declaration, signed by all Ministerial officials who attended the meeting. With agreed priorities for stroke prevention, treatment, and research, an opportunity now exists to translate this Declaration into an action plan to reduce the burden of stroke.
Source: The Lancet Neurology - April 26, 2019 Category: Neurology Source Type: research
Stroke genetics: discovery, biology, and clinical applications
Publication date: Available online 8 April 2019Source: The Lancet NeurologyAuthor(s): Martin Dichgans, Sara L Pulit, Jonathan RosandSummaryStroke, a leading cause of long-term disability and death worldwide, has a heritable component. Recent gene discovery efforts have expanded the number of known single-gene disorders associated with stroke and have linked common variants at approximately 35 genetic loci to stroke risk. These discoveries have highlighted novel mechanisms and pathways implicated in stroke related to large artery atherosclerosis, cardioembolism, and small vessel disease, and defined shared genetic influence...
Source: The Lancet Neurology - April 9, 2019 Category: Neurology Source Type: research
Imaging biomarkers of vulnerable carotid plaques for stroke risk prediction and their potential clinical implications
Publication date: Available online 4 April 2019Source: The Lancet NeurologyAuthor(s): Luca Saba, Tobias Saam, H Rolf Jäger, Chun Yuan, Thomas S Hatsukami, David Saloner, Bruce A Wasserman, Leo H Bonati, Max WintermarkSummaryStroke represents a massive public health problem. Carotid atherosclerosis plays a fundamental part in the occurence of ischaemic stroke. European and US guidelines for prevention of stroke in patients with carotid plaques are based on quantification of the percentage reduction in luminal diameter due to the atherosclerotic process to select the best therapeutic approach. However, better strategies for...
Source: The Lancet Neurology - April 4, 2019 Category: Neurology Source Type: research
