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Source: The Lancet Neurology
Condition: Stroke

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Total 244 results found since Jan 2013.

Fresh frozen plasma versus prothrombin complex concentrate in patients with intracranial haemorrhage related to vitamin K antagonists (INCH): a randomised trial
Publication date: May 2016 Source:The Lancet Neurology, Volume 15, Issue 6 Author(s): Thorsten Steiner, Sven Poli, Martin Griebe, Johannes Hüsing, Jacek Hajda, Anja Freiberger, Martin Bendszus, Julian Bösel, Hanne Christensen, Christian Dohmen, Michael Hennerici, Jennifer Kollmer, Henning Stetefeld, Katja E Wartenberg, Christian Weimar, Werner Hacke, Roland Veltkamp Background Haematoma expansion is a major cause of mortality in intracranial haemorrhage related to vitamin K antagonists (VKA-ICH). Normalisation of the international normalised ratio (INR) is recommended, but optimum haemostatic managemen...
Source: The Lancet Neurology - April 19, 2016 Category: Neurology Source Type: research

Identification of additional risk loci for stroke and small vessel disease: a meta-analysis of genome-wide association studies
Publication date: Available online 7 April 2016 Source:The Lancet Neurology Author(s): Neurology Working Group of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) ConsortiumStroke Genetics Network (SiGN)International Stroke Genetics Consortium (ISGC) Background Genetic determinants of stroke, the leading neurological cause of death and disability, are poorly understood and have seldom been explored in the general population. Our aim was to identify additional loci for stroke by doing a meta-analysis of genome-wide association studies. Methods For the discovery sample, we did a genome-wide analys...
Source: The Lancet Neurology - April 7, 2016 Category: Neurology Source Type: research

A stroke of insight from genetics
Publication date: Available online 7 April 2016 Source:The Lancet Neurology Author(s): Peter M Visscher, Jan H Veldink
Source: The Lancet Neurology - April 7, 2016 Category: Neurology Source Type: research

South Africa: stroke units out of the blue
Publication date: April 2016 Source:The Lancet Neurology, Volume 15, Issue 4 Author(s): Adrian Burton
Source: The Lancet Neurology - March 9, 2016 Category: Neurology Source Type: research

Human genetics shines a light on ischaemic stroke
Publication date: Available online 19 December 2015 Source:The Lancet Neurology Author(s): Benjamin F Voight, Daniel J Rader
Source: The Lancet Neurology - December 19, 2015 Category: Neurology Source Type: research

Loci associated with ischaemic stroke and its subtypes (SiGN): a genome-wide association study
Publication date: Available online 19 December 2015 Source:The Lancet Neurology Author(s): NINDS Stroke Genetics Network (SiGN)International Stroke Genetics Consortium (ISGC) Background The discovery of disease-associated loci through genome-wide association studies (GWAS) is the leading genetic approach to the identification of novel biological pathways underlying diseases in humans. Until recently, GWAS in ischaemic stroke have been limited by small sample sizes and have yielded few loci associated with ischaemic stroke. We did a large-scale GWAS to identify additional susceptibility genes for stroke and its subtypes. ...
Source: The Lancet Neurology - December 19, 2015 Category: Neurology Source Type: research

Stroke in 2015: the year of endovascular treatment
Publication date: January 2016 Source:The Lancet Neurology, Volume 15, Issue 1 Author(s): Keith W Muir
Source: The Lancet Neurology - December 8, 2015 Category: Neurology Source Type: research

Clinical course of untreated cerebral cavernous malformations: a meta-analysis of individual patient data
Publication date: Available online 2 December 2015 Source:The Lancet Neurology Author(s): Margaret A Horne, Kelly D Flemming, I-Chang Su, Christian Stapf, Jin Pyeong Jeon, Da Li, Susanne S Maxwell, Philip White, Teresa J Christianson, Ronit Agid, Won-Sang Cho, Chang Wan Oh, Zhen Wu, Jun-Ting Zhang, Jeong Eun Kim, Karel ter Brugge, Robert Willinsky, Robert D Brown, Gordon D Murray, Rustam Al-Shahi Salman Background Cerebral cavernous malformations (CCMs) can cause symptomatic intracranial haemorrhage (ICH), but the estimated risks are imprecise and predictors remain uncertain. We aimed to obtain precis...
Source: The Lancet Neurology - December 3, 2015 Category: Neurology Source Type: research

Development of epilepsy after ischaemic stroke
Publication date: Available online 17 November 2015 Source:The Lancet Neurology Author(s): Asla Pitkänen, Reina Roivainen, Katarzyna Lukasiuk For about 30% of patients with epilepsy the cause is unknown. Even in patients with a known risk factor for epilepsy, such as ischaemic stroke, only a subpopulation of patients develops epilepsy. Factors that contribute to the risk for epileptogenesis in a given individual generally remain unknown. Studies in the past decade on epilepsy in patients with ischaemic stroke suggest that, in addition to the primary ischaemic injury, existing difficult-to-detect microscale changes in...
Source: The Lancet Neurology - November 17, 2015 Category: Neurology Source Type: research

Cranial functional (psychogenic) movement disorders
Publication date: December 2015 Source:The Lancet Neurology, Volume 14, Issue 12 Author(s): Diego Kaski, Adolfo M Bronstein, Mark J Edwards, Jon Stone Functional (psychogenic) neurological symptoms are frequently encountered in neurological practice. Cranial movement disorders—affecting the eyes, face, jaw, tongue, or palate—are an under-recognised feature of patients with functional symptoms. They can present in isolation or in the context of other functional symptoms; in particular, for functional eye movements, positive clinical signs such as convergence spasms can be triggered by the clinical examination. Alt...
Source: The Lancet Neurology - November 11, 2015 Category: Neurology Source Type: research

The effects of socioeconomic status on stroke risk and outcomes
Publication date: December 2015 Source:The Lancet Neurology, Volume 14, Issue 12 Author(s): Iain J Marshall, Yanzhong Wang, Siobhan Crichton, Christopher McKevitt, Anthony G Rudd, Charles D A Wolfe The latest evidence on socioeconomic status and stroke shows that stroke not only disproportionately affects low-income and middle-income countries, but also socioeconomically deprived populations within high-income countries. These disparities are reflected not only in risk of stroke but also in short-term and long-term outcomes after stroke. Increased average levels of conventional risk factors (eg, hypertension, hyper...
Source: The Lancet Neurology - November 11, 2015 Category: Neurology Source Type: research

Safety and efficacy of abobotulinumtoxinA for hemiparesis in adults with upper limb spasticity after stroke or traumatic brain injury: a double-blind randomised controlled trial
This study is registered with ClinicalTrials.gov, number NCT01313299. Findings 243 patients were randomly allocated to placebo (n=81), abobotulinumtoxinA 500 U (n=81), or abobotulinumtoxinA 1000 U (n=81). Mean change in MAS score from baseline at week 4 in the PTMG was −0·3 (SD 0·6) in the placebo group (n=79), −1·2 (1·0) in the abobotulinumtoxinA 500 U group (n=80; difference −0·9, 95% CI −1·2 to −0·6; p<0·0001 vs placebo), and −1·4 (1·1) in the abobotulinumtoxinA 1000 U group (n=79; −1·1, −1·4 to −0·8; p<0·0001 vs placebo). Mean PGA score at week 4 was 0·6 (SD 1·0) in the ...
Source: The Lancet Neurology - August 27, 2015 Category: Neurology Source Type: research

Peter Rothwell: aspirin(g) physician with a little stroke of genius
Publication date: September 2015 Source:The Lancet Neurology, Volume 14, Issue 9 Author(s): Adrian Burton
Source: The Lancet Neurology - August 25, 2015 Category: Neurology Source Type: research

Diagnosis of Parkinson's disease on the basis of clinical and genetic classification: a population-based modelling study
Publication date: Available online 10 August 2015 Source:The Lancet Neurology Author(s): Mike A Nalls, Cory Y McLean, Jacqueline Rick, Shirley Eberly, Samantha J Hutten, Katrina Gwinn, Margaret Sutherland, Maria Martinez, Peter Heutink, Nigel M Williams, John Hardy, Thomas Gasser, Alexis Brice, T Ryan Price, Aude Nicolas, Margaux F Keller, Cliona Molony, J Raphael Gibbs, Alice Chen-Plotkin, Eunran Suh, Christopher Letson, Massimo S Fiandaca, Mark Mapstone, Howard J Federoff, Alastair J Noyce, Huw Morris, Vivianna M Van Deerlin, Daniel Weintraub, Cyrus Zabetian, Dena G Hernandez, Suzanne Les...
Source: The Lancet Neurology - August 11, 2015 Category: Neurology Source Type: research

Home-based constraint-induced movement therapy for patients with upper limb dysfunction after stroke (HOMECIMT): a cluster-randomised, controlled trial
Publication date: Available online 28 July 2015 Source:The Lancet Neurology Author(s): Anne Barzel, Gesche Ketels, Anne Stark, Britta Tetzlaff, Anne Daubmann, Karl Wegscheider, Hendrik van den Bussche, Martin Scherer Background Constraint-induced movement therapy (CIMT) is recommended for patients with upper limb dysfunction after stroke, yet evidence to support the implementation of CIMT in ambulatory care is insufficient. We assessed the efficacy of home CIMT, a modified form of CIMT that trains arm use in daily activities within the home environment. Methods In this parallel, cluster-randomised controlled tri...
Source: The Lancet Neurology - July 30, 2015 Category: Neurology Source Type: research