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Source: The Lancet Neurology
Condition: Stroke
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Total 244 results found since Jan 2013.
Stroke research in 2016: when more medicine is better, and when it isn't
Publication date: January 2017 Source:The Lancet Neurology, Volume 16, Issue 1 Author(s): Peter M Rothwell
Source: The Lancet Neurology - December 6, 2016 Category: Neurology Source Type: research
Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies: a retrospective analysis
Publication date: January 2017 Source:The Lancet Neurology, Volume 16, Issue 1 Author(s): David J Irwin, Murray Grossman, Daniel Weintraub, Howard I Hurtig, John E Duda, Sharon X Xie, Edward B Lee, Vivianna M Van Deerlin, Oscar L Lopez, Julia K Kofler, Peter T Nelson, Gregory A Jicha, Randy Woltjer, Joseph F Quinn, Jeffery Kaye, James B Leverenz, Debby Tsuang, Katelan Longfellow, Dora Yearout, Walter Kukull, C Dirk Keene, Thomas J Montine, Cyrus P Zabetian, John Q Trojanowski Background Great heterogeneity exists in survival and the interval between onset of motor symptoms and dementia symptoms across synucleinopathies. W...
Source: The Lancet Neurology - December 6, 2016 Category: Neurology Source Type: research
Neurological manifestations of autosomal dominant familial Alzheimer ’s disease: a comparison of the published literature with the Dominantly Inherited Alzheimer Network observational study (DIAN-OBS)
Publication date: December 2016 Source:The Lancet Neurology, Volume 15, Issue 13 Author(s): Mengxuan Tang, Davis C Ryman, Eric McDade, Mateusz S Jasielec, Virginia D Buckles, Nigel J Cairns, Anne M Fagan, Alison Goate, Daniel S Marcus, Chengjie Xiong, Ricardo F Allegri, Jasmeer P Chhatwal, Adrian Danek, Martin R Farlow, Nick C Fox, Bernardino Ghetti, Neill R Graff-Radford, Christopher Laske, Ralph N Martins, Colin L Masters, Richard P Mayeux, John M Ringman, Martin N Rossor, Stephen P Salloway, Peter R Schofield, John C Morris, Randall J Bateman Background Autosomal dominant familial Alzheimer’s disease (ADAD) is a rare...
Source: The Lancet Neurology - November 7, 2016 Category: Neurology Source Type: research
Impaired consciousness in patients with absence seizures investigated by functional MRI, EEG, and behavioural measures: a cross-sectional study
Publication date: December 2016 Source:The Lancet Neurology, Volume 15, Issue 13 Author(s): Jennifer N Guo, Robert Kim, Yu Chen, Michiro Negishi, Stephen Jhun, Sarah Weiss, Jun Hwan Ryu, Xiaoxiao Bai, Wendy Xiao, Erin Feeney, Jorge Rodriguez-Fernandez, Hetal Mistry, Vincenzo Crunelli, Michael J Crowley, Linda C Mayes, R Todd Constable, Hal Blumenfeld Background The neural underpinnings of impaired consciousness and of the variable severity of behavioural deficits from one absence seizure to the next are not well understood. We aimed to measure functional MRI (fMRI) and electroencephalography (EEG) changes in absence seizu...
Source: The Lancet Neurology - November 7, 2016 Category: Neurology Source Type: research
DNM3 and genetic modifiers of age of onset in LRRK2 Gly2019Ser parkinsonism: a genome-wide linkage and association study
Publication date: Available online 28 September 2016 Source:The Lancet Neurology Author(s): Joanne Trinh, Emil K Gustavsson, Carles Vilariño-Güell, Stephanie Bortnick, Jeanne Latourelle, Marna B McKenzie, Chelsea Szu Tu, Ekaterina Nosova, Jaskaran Khinda, Austen Milnerwood, Suzanne Lesage, Alexis Brice, Meriem Tazir, Jan O Aasly, Laura Parkkinen, Hazal Haytural, Tatiana Foroud, Richard H Myers, Samia Ben Sassi, Emna Hentati, Fatma Nabli, Emna Farhat, Rim Amouri, Fayçal Hentati, Matthew J Farrer Background Leucine-rich repeat kinase 2 (LRRK2) mutation 6055G→A (Gly2019Ser) accounts for roughly 1% of patients with Parki...
Source: The Lancet Neurology - September 28, 2016 Category: Neurology Source Type: research
Mechanical thrombectomy after intravenous alteplase versus alteplase alone after stroke (THRACE): a randomised controlled trial
Publication date: Available online 23 August 2016 Source:The Lancet Neurology Author(s): Serge Bracard, Xavier Ducrocq, Jean Louis Mas, Marc Soudant, Catherine Oppenheim, Thierry Moulin, Francis Guillemin Background Intravenous thrombolysis with alteplase alone cannot reperfuse most large-artery strokes. We aimed to determine whether mechanical thrombectomy in addition to intravenous thrombolysis improves clinical outcome in patients with acute ischaemic stroke. Methods THRACE is a randomised controlled trial done in 26 centres in France. Patients aged 18–80 years with acute ischaemic stroke and proximal cerebral artery...
Source: The Lancet Neurology - August 23, 2016 Category: Neurology Source Type: research
Intra-arterial therapy for acute ischaemic stroke
Publication date: Available online 23 August 2016 Source:The Lancet Neurology Author(s): Olvert A Berkhemer, Diederik W J Dippel
Source: The Lancet Neurology - August 23, 2016 Category: Neurology Source Type: research
Safety and efficacy of intravenous glyburide on brain swelling after large hemispheric infarction (GAMES-RP): a randomised, double-blind, placebo-controlled phase 2 trial
Publication date: Available online 23 August 2016 Source:The Lancet Neurology Author(s): Kevin N Sheth, Jordan J Elm, Bradley J Molyneaux, Holly Hinson, Lauren A Beslow, Gordon K Sze, Ann-Christin Ostwaldt, Gregory J del Zoppo, J Marc Simard, Sven Jacobson, W Taylor Kimberly Background Preclinical models of stroke have shown that intravenous glyburide reduces brain swelling and improves survival. We assessed whether intravenous glyburide (RP-1127; glibenclamide) would safely reduce brain swelling, decrease the need for decompressive craniectomy, and improve clinical outcomes in patients presenting with a large hemispheric...
Source: The Lancet Neurology - August 23, 2016 Category: Neurology Source Type: research
Virtual reality versus reality in post-stroke rehabilitation
Publication date: September 2016 Source:The Lancet Neurology, Volume 15, Issue 10 Author(s): Brian Silver
Source: The Lancet Neurology - August 8, 2016 Category: Neurology Source Type: research
Efficacy and safety of non-immersive virtual reality exercising in stroke rehabilitation (EVREST): a randomised, multicentre, single-blind, controlled trial
Publication date: September 2016 Source:The Lancet Neurology, Volume 15, Issue 10 Author(s): Gustavo Saposnik, Leonardo G Cohen, Muhammad Mamdani, Sepideth Pooyania, Michelle Ploughman, Donna Cheung, Jennifer Shaw, Judith Hall, Peter Nord, Sean Dukelow, Yongchai Nilanont, Felipe De los Rios, Lisandro Olmos, Mindy Levin, Robert Teasell, Ashley Cohen, Kevin Thorpe, Andreas Laupacis, Mark Bayley Background Non-immersive virtual reality is an emerging strategy to enhance motor performance for stroke rehabilitation. There has been rapid adoption of non-immersive virtual reality as a rehabilitation strategy despite the limited ...
Source: The Lancet Neurology - August 8, 2016 Category: Neurology Source Type: research
Global burden of stroke and risk factors in 188 countries, during 1990 –2013: a systematic analysis for the Global Burden of Disease Study 2013
Publication date: August 2016 Source:The Lancet Neurology, Volume 15, Issue 9 Author(s): Valery L Feigin, Gregory A Roth, Mohsen Naghavi, Priya Parmar, Rita Krishnamurthi, Sumeet Chugh, George A Mensah, Bo Norrving, Ivy Shiue, Marie Ng, Kara Estep, Kelly Cercy, Christopher J L Murray, Mohammad H Forouzanfar Background The contribution of modifiable risk factors to the increasing global and regional burden of stroke is unclear, but knowledge about this contribution is crucial for informing stroke prevention strategies. We used data from the Global Burden of Disease Study 2013 (GBD 2013) to estimate the popul...
Source: The Lancet Neurology - July 20, 2016 Category: Neurology Source Type: research
Effects of alteplase on survival after ischaemic stroke (IST-3): 3 year follow-up of a randomised, controlled, open-label trial
We report the effect of intravenous alteplase on long-term survival after ischaemic stroke of participants in the Third International Stroke Trial (IST-3). Methods In IST-3, done at 156 hospitals in 12 countries (Australia, Europe, and the UK), participants (aged >18 years) were randomly assigned with a telephone voice-activated or web-based system in a 1:1 ratio to treatment with intravenous 0·9 mg/kg alteplase plus standard care or standard care alone within 6 h of ischaemic stroke. We followed up participants in the UK and Scandinavia (Sweden and Norway) for survival up to 3 years after randomisation using data...
Source: The Lancet Neurology - July 19, 2016 Category: Neurology Source Type: research
The pros and cons of intravenous thrombolysis in stroke
Publication date: Available online 20 July 2016 Source:The Lancet Neurology Author(s): Rüdiger J Seitz
Source: The Lancet Neurology - July 19, 2016 Category: Neurology Source Type: research
Functional outcomes of pre-hospital thrombolysis in a mobile stroke treatment unit compared with conventional care: an observational registry study
This study is registered with ClinicalTrials.gov, number NCT02358772. Findings Between Feb 5, 2011, and March 5, 2015, 427 patients were treated within the STEMO vehicle and their data were entered into a pre-hospital registry. 505 patients received conventional care and their data were entered into an in-hospital thrombolysis registry. Of these, 305 patients in the STEMO group and 353 in the conventional care group met inclusion criteria and were included in the analysis. 161 (53%) patients in the STEMO group versus 166 (47%) in the conventional care group had an mRS score of 1 or lower (p=0·14). Compared with conventio...
Source: The Lancet Neurology - July 15, 2016 Category: Neurology Source Type: research
Can emergency stroke care be delivered in an ambulance?
Publication date: Available online 16 July 2016 Source:The Lancet Neurology Author(s): Anthony G Rudd
Source: The Lancet Neurology - July 15, 2016 Category: Neurology Source Type: research
